Action Potential

Lai et al.

Dynorphin A activates bradykinin receptors to maintain neuropathic pain

Opioids usually alleviate pain by acting at opiate receptors, but this study now reports that the opioid dynorphin A can also activate bradykinin receptors, thereby contributing to neuropathic pain.

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    Amiya Sarkar said:

    Very interesting! Some kind of ‘gating’ or a ‘permissive’ pathway may be behind this. Curiously, drugs curing fever (aspirin) cause fever (pyrexia) themselves and antimalignancy compounds are themselves carcinogenic.