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Archive by author | Brooke LaFlamme

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27 Apr 2017 | 15:35 BST

From the archives (2004): Large-scale structural variation in the human genome

Posted by Brooke LaFlamme | Categories: History of genetics

From the archives (2004): Large-scale structural variation in the human genome

During the past 25 years, Nature Genetics has been lucky to publish many exciting papers, more than a few of which can be described as “landmark” papers—publications that have had a dramatic and long-lasting impact on a field. In 2004, the Journal published such a study by Stephen Scherer, Charles Lee and colleagues (Iafrate et al.) in which they reported 255 loci across the human genome containing large structural variants.  Read more

Tags:

  • behind the scenes
  • copy number variation
  • human genetics

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20 Apr 2017 | 14:35 BST

From the archives (1995): Guidelines for interpreting and reporting linkage results

Posted by Brooke LaFlamme | Categories: History of genetics, Linkage

From the archives (1995): Guidelines for interpreting and reporting linkage results

In 1995, Nature Genetics published a report by Eric Lander and Leonid Kruglyak, recommending clear statistical guidelines for reporting linkage results for complex traits. The paper had an immediate impact, setting the bar for what could or could not be called “significant” in the literature. Although originally focused on human genetic linkage studies, the guidelines set forth by Lander & Kruglyak influenced fields from model organism genetics to plant genetics, and eventually genome-wide association studies (GWAS).  Read more

Tags:

  • association studies
  • behind the scenes
  • guidelines
  • linkage mapping
  • statistics

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03 Apr 2017 | 08:23 BST

Woolly mammoth hemoglobin brought to life: From the archives (2010)

Posted by Brooke LaFlamme | Categories: Nature Genetics Anniversary

Woolly mammoth hemoglobin brought to life: From the archives (2010)

As part of the ongoing celebration of the last 25 years of Nature Genetics, the editors are each choosing a few papers from our archives that we want to highlight. My first pick a paper from Kevin Campbell, Alan Cooper and colleagues on their structure-function analysis of woolly mammoth hemoglobin, published in May 2010.  Read more

Tags:

  • ancient DNA
  • comparative sequence analysis
  • evolution

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31 Mar 2017 | 15:21 BST

25 years of Nature Genetics

Posted by Brooke LaFlamme | Categories: History of genetics, News and Events

25 years of Nature Genetics

   … Read more

Tags:

  • 25th anniversary
  • behind the scenes
  • genomics

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25 Oct 2016 | 21:59 BST

October issue cover: What’s going on here?

Posted by Brooke LaFlamme | Categories: Nature Genetics covers

October issue cover: What's going on here?

For all of October, we at Nature Genetics have been admiring the lovely cabbages on our cover. The image, created by photographer Keyong Chang, was contributed by the authors of the study on page 1218 of the issue.  Read more

Tags:

  • Brassica
  • cabbage
  • China
  • crop biology
  • domestication
  • genome evolution

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24 Oct 2016 | 20:07 BST

Learning every way to break a gene

Posted by Brooke LaFlamme | Categories: Gene function

Learning every way to break a gene

Finding the genetic cause of a disease—a mutation or genetic variant—is a lot like looking for a needle in a haystack. Except in the case of exome sequencing, it’s not always clear what a needle even looks like.  Read more

Tags:

  • behind the scenes
  • functional genomics
  • medical genomics
  • PPARG
  • variants of uncertain significance

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28 Sep 2016 | 13:41 BST

Spreadsheets have misprints – it is known

Posted by Brooke LaFlamme | Categories: Nature Genetics standards

Spreadsheets have misprints – it is known

Normally we do not re-examine supplementary information in this detail, but there is a common minor problem that systematically affects a small number of gene IDs within long lists of gene names copied into spreadsheets in the supplementary tables of many articles. We suggest checking for this problem before submitting tables to journals. It is easy to see the altered gene names by sorting the column in a separate version of the file and then searching for the misspelled name to correct it in the replacement version intended for publication.  Read more

Tags:

  • autocorrect
  • Corrigenda
  • Excel
  • gene lists
  • spreadsheets

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22 Aug 2016 | 15:46 BST

August issue cover: What’s going on here?

Posted by Brooke LaFlamme | Categories: Nature Genetics covers

August issue cover: What's going on here?

This month’s cover image is inspired by the paper on page 947 reporting the reference genome sequence of the black snub-nosed monkey, the second snub-nosed monkey genome paper published in Nature Genetics. The golden snub-nosed monkey genome was published in 2014.  Read more

Tags:

  • behind the scenes
  • monkeying around
  • reference genomes
  • snub-nosed monkeys

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22 Jul 2016 | 20:21 BST

July issue cover: What’s going on here?

Posted by Brooke LaFlamme | Categories: Nature Genetics covers

July issue cover: What's going on here?

This month’s cover features the inspiring block-like karst mountains of the Li River between Guilin and Yangshuo in Guangxi province. The image was inspired by a study in this month’s issue reporting deep sequencing of the MHC region in individuals of Han Chinese ancestry. The study represents an important resource for the study of immune-related disorders in Asian populations. It also identifies loci associated with risk of psoriasis, thus demonstrating the power of this resource.  Read more

Tags:

  • China
  • Editors at large
  • MHC

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24 Jun 2016 | 14:18 BST

June issue cover: What’s going on here?

Posted by Brooke LaFlamme | Categories: Nature Genetics covers

June issue cover: What's going on here?

As June comes to a close, it’s time to look back at our June issue and ask “what’s going on here?” with the cover image. As you may have guessed, the image is related to the publication of the carrot genome sequence in this month’s issue.  Read more

Tags:

  • carrot
  • carrot genome
  • genome sequence
  • genomics
  • Rachel Meyer
  • science as art

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