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Archive by tag | zebrafish

03 Nov 2014 | 18:57 GMT

The genetic syntax of febrile seizures

Posted by Brooke LaFlamme | Categories: Linkage

The genetic syntax of febrile seizures

The genetics of seizure disorders, including epilepsy, has recently come into the spotlight (see the Nature Outlook on epilepsy). Epilepsy is a complex disease with many different subtypes, both sporadic and familial. While epilepsy is one of the most common neurological disorders, and it has been studied for a very long time, the underlying mechanisms of seizure disorders remain largely elusive. Identifying the genetic causes of different subtypes of the disorder can help to illuminate the gene networks involved and lead to a deeper understanding overall. Importantly, the genetic tools now exist to identify causal mutations for the many different subtypes of seizure disorders.  Read more

Tags:

  • behind the scenes
  • epilepsy
  • exome sequencing
  • febrile seizures
  • Holger Lerche
  • human genetics
  • STX1B
  • zebrafish

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18 Mar 2013 | 15:53 GMT

Whole brain cellular-level activity mapping in a second

Posted by erika pastrana | Categories: Microscopy & Imaging, Model Organisms, Neuroscience

Whole brain cellular-level activity mapping in a second

It is now possible to map the activity of nearly all the neurons in a vertebrate brain at cellular resolution. What does this mean for neuroscience research and projects like the Brain Activity Map proposal?  Read more

Tags:

  • brain
  • fluorescence microscopy
  • fluorescent sensors
  • neurons
  • zebrafish

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18 Jul 2012 | 13:47 BST

One fish, two fish and 400,000 zebrafish

Posted by Kathleen Raven | Categories: Odds and ends

One fish, two fish and 400,000 zebrafish

Hundreds of translucent creatures that biomedical researchers rely on for genetic insights settled into new digs today as researchers opened a newly refurbished and expanded animal repository called the European Zebrafish Resource Center. Housed at the Karlsruhe Institute of Technology (KIT) in southwest Germany, the center can maintain 400,000 live fish at maximum capacity in more than 3,000 tanks, and will include lab space for on-site zebrafish in vitro fertilization. Uwe Strähle, a geneticist at KIT, told Nature Medicine by phone after the ribbon-cutting ceremony that European zebrafish researchers eager to preserve their hard-won transgenic and mutant lines may begin submitting eggs to the center. Currently the center houses 300 transgenic lines but Strähle expected the collection to expand to hold thousands of lines in the next five years.  Read more

Tags:

  • European
  • Karlsruhe Institute of Technology
  • zebrafish

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10 May 2012 | 21:24 BST

“There is no spoon…”: Paralyzed fish navigates virtual environment while we watch its brain

Posted by Noah Gray | Categories: New in Nature, Noah Gray

"There is no spoon...": Paralyzed fish navigates virtual environment while we watch its brain

Sometimes an experiment will just reach off the page and slap you in the face, demanding attention. This happens to me every so often and I must admit, our latest paper from the lab of Florien Engert induced such an experience. There have been several cool, technical tours-de-force (is that proper grammar??) over the last few years involving different creatures navigating in a virtual environment while neuronal activity was monitored. These include a mouse running on a spherical treadmill, as well as a fly marching along a similar treadmill-style ball. But in these examples, having the subject head-fixed (for the stability of recordings in the brain, either with electrodes or through imaging) was moderately non-intrusive since walking motions were independent of the head. The same can’t be said for the subject in this latest example of a virtual reality navigator: a wriggling, swimming fish. Therefore, a more creative solution had to be sought and in a paper published online yesterday, Ahrens, Engert and colleagues decided that paralysis was the way to go in order to follow the neural activity of this navigating fish.  Read more

Tags:

  • adaptation
  • calcium imaging
  • cerebellum
  • decoding
  • motor learning
  • Nature
  • navigation
  • neural circuits
  • neural plasticity
  • neurons
  • neuroscience
  • virtual reality
  • zebrafish

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