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Archive by tag | autism

15 Sep 2014 | 09:00 BST

Pinpointing genes underlying developmental delay

Posted by Brooke LaFlamme | Categories: Genetic association, Genomics

Pinpointing genes underlying developmental delay

A paper published online this week at Nature Genetics uses an innovative method to find new genes that contribute to neurocognitive disorders, such as autism.  Read more

Tags:

  • autism
  • behind the scenes
  • cognitive disorders
  • copy number variation
  • developmental delay
  • Evan Eichler
  • intellectual disability
  • mental health
  • neurodevelopmental disorders
  • neuropsychiatric disorders

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07 Aug 2012 | 00:21 BST

Epigenetic convergence in intellectual disability and cancer?

Posted by Pamela Feliciano | Categories: Uncategorized

One of the many remarkable findings of the cancer genome sequencing projects that have been published in this and other journals is the repeated discovery of somatic driver mutations in genes that encode chromatin remodeling factors, which regulate the epigenome. De novo mutations in this same family of genes also cause several developmental syndromes, whose various features all include intellectual disability. Surprisingly, a few de novo mutations in these genes have recently been reported in autism. How do these mutations (which at least in some cases appear to be loss-of-function in both cancer and in the developmental syndromes) in the same class, and in some cases, the same exact genes cause these different diseases?  Read more

Tags:

  • autism
  • Cancer genomics
  • chromatin
  • epigenome
  • intellectual disability

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