nature.com

Sitemap

  • Log In
  • Register

Free Association

a blog from Nature Genetics

Advanced search
  • Nature Genetics
  • Blog
  • Archive by Tag

Archive by tag | Cancer genomics

09 Dec 2014 | 19:47 GMT

A piggyBac ride to pancreatic cancer genes

Posted by Brooke LaFlamme | Categories: Cancer

A cluster of pancreatic cancer cells. Scanning electron micrograph

Pancreatic cancer is a highly heterogeneous disease that often has a poor prognosis. Development of drugs or treatment strategies to target cancers, including pancreatic cancer, depends on identifying the drivers of disease. These are the genes that promote carcinogenesis and coordinate development of the cancer. But by the time a patient is diagnosed, it can often be very difficult to tell which of the many mutations present in the tumor are actually disease drivers, and which are just along for the ride.  Read more

Tags:

  • behind the scenes
  • Cancer genomics
  • forward genetics
  • mouse models
  • pancreatic cancer
  • piggyBac
  • Roland Rad
  • transposon screen

Article tools

  • add a comment
  • Email
  • Share/bookmark

    • Facebook
    • Twitter
    • Delicious
    • Digg
    • Google+
    • LinkedIn
    • Reddit
    • StumbleUpon

27 Sep 2013 | 10:44 BST

Focus on TCGA Pan-Cancer Analysis

Posted by Orli Bahcall | Categories: Cancer, Data sharing, Genomics

Nature Genetics is pleased to present today the first installment of our Focus on TCGA Pan-Cancer Analysis.  Read more

Tags:

  • Cancer
  • Cancer genomics
  • Clinical translation
  • Common Diseases
  • Genomics
  • Open data
  • TCGA

Article tools

  • add a comment
  • Email
  • Share/bookmark

    • Facebook
    • Twitter
    • Delicious
    • Digg
    • Google+
    • LinkedIn
    • Reddit
    • StumbleUpon

07 Aug 2012 | 00:21 BST

Epigenetic convergence in intellectual disability and cancer?

Posted by Pamela Feliciano | Categories: Uncategorized

One of the many remarkable findings of the cancer genome sequencing projects that have been published in this and other journals is the repeated discovery of somatic driver mutations in genes that encode chromatin remodeling factors, which regulate the epigenome. De novo mutations in this same family of genes also cause several developmental syndromes, whose various features all include intellectual disability. Surprisingly, a few de novo mutations in these genes have recently been reported in autism. How do these mutations (which at least in some cases appear to be loss-of-function in both cancer and in the developmental syndromes) in the same class, and in some cases, the same exact genes cause these different diseases?  Read more

Tags:

  • autism
  • Cancer genomics
  • chromatin
  • epigenome
  • intellectual disability

Article tools

  • add a comment
  • Email
  • Share/bookmark

    • Facebook
    • Twitter
    • Delicious
    • Digg
    • Google+
    • LinkedIn
    • Reddit
    • StumbleUpon

29 Jan 2012 | 18:07 GMT

Somatic mutations in histone H3 in pediatric brain tumors

Posted by Pamela Feliciano | Categories: Uncategorized

Glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG) are aggressive subtypes of brain tumors that both have a very poor prognosis and are almost always lethal. Two new studies in Nature and this journal today identify the same recurrent mutations in H3F3A in pediatric cases of glioblastoma multiforme and diffuse intrinsic pontine glioma. These are the first reports of human disease associated with mutations in histones, which play an extraordinarily important and conserved role in chromatin structure and gene regulation. With the recent spate of papers reporting somatic mutations in chromatin remodelers in various types of cancer (examples from this journal alone include the histone H3K27 demethylase UTX, transitional cell carcinoma of the bladder, histone methyltransferase EZH2 in follicular and diffuse large B-cell lymphoma and myeloid disorders, DNMT3A in AML, ARID2 in hepatocellular carcinoma, MLL2 in DLBCL, and ARID1a in gastric cancer) it is clear that targeting the chromatin remodeling machinery will be an important area in the development of new cancer drugs.  Read more

Tags:

  • Cancer genomics

Article tools

  • 1 Comment
  • Email
  • Share/bookmark

    • Facebook
    • Twitter
    • Delicious
    • Digg
    • Google+
    • LinkedIn
    • Reddit
    • StumbleUpon

Current issue

May, Volume 49 No 5
  • Journal home
  • About
  • Current issue
  • Subscribe
  • Recommend to library
  • E-alert
  • RSS
  • Facebook
  • Twitter
nature.com blogs home

Featured posts from this blog

  • Cancer, Genomics

    Cancer clones- mixing and spreading

    • add a comment
  • Cancer, Conference Highlights, Data sharing

    Human Genome Meeting 2016

    • add a comment
  • Cancer, Gene regulation

    The many ways MYB drives cancer

    • 1 Comment
  • Cancer, Epigenetics, Gene regulation

    Methylation marks tumor suppressors

    • add a comment
  • Cancer

    APOBEC3A takes the lead

    • add a comment

View more

Blog Archive

  • A view From the BridgeA view From the Bridge
  • Action PotentialAction Potential
  • Flat Chat Flat Chat
  • Free AssociationFree Association
  • House of WisdomHouse of Wisdom
  • IndigenusIndigenus
  • MethagoraMethagora
  • Nature Future ConditionalNature Future Conditional
  • nature.com blogsnature.com blogs
  • Naturejobs BlogNaturejobs Blog
  • Of Schemes and Memes BlogOf Schemes and Memes Blog
  • On your wavelengthOn your wavelength
  • Plant LifePlant Life
  • Scientific DataScientific Data
  • Soapbox ScienceSoapbox Science
  • Spoonful of MedicineSpoonful of Medicine
  • StepwiseStepwise
  • The Sceptical ChymistThe Sceptical Chymist
  • Trade SecretsTrade Secrets
  • About us
  • Contact us
  • Accessibility statement
  • Help
  • Privacy policy
  • Use of cookies
  • Legal notice
  • Terms
  • Nature jobs
  • Nature Asia
  • Nature Education
  • RSS web feeds
Advanced search

© 2021 Springer Nature Limited. All Rights Reserved. partner of AGORA, HINARI, OARE, INASP, ORCID, CrossRef and COUNTER