I had a chance to ask ASCB president Bruce Alberts what had him excited about this year’s meeting. He directed me to a session (actually two sessions) that take a bit of a departure from the usual format. I went to the working group symposium on the cell biology of Alzheimer’s disease (AD). Rather than present data, we got outlines of future prospects and directions from two established experts in AD research and two cell biologists who have come to study AD from different directions. Audience participation was encouraged, and it made for some good arguments that I daresay seemed the slightest bit productive. I’ll warn you that there’s a bit of alphabet soup coming, but bear with me, there are some neat new ideas here.