Nature Methods has published popular analysis tools to make sense of the ever-increasing amount of high throughput (HTP) sequencing data. Some tools in this field have a short half life, due to pressure to always improve and innovate, others have staying power. Let’s look back over some of the highlights in our pages. Read more
To study a primordial nervous system, Leonid Moroz brings the tools of biology to the open sea. Nature Methods spoke with the neurobiologist turned sea adventurer. Meet neurobiologist Leonid Moroz of the University of Florida, the inventor of Ship-Seq. His hair is not always this wild, although his ideas tend to be. Read more
Single-cell sequencing edged out other contenders as our choice of Method of the Year in 2013. These techniques really came into their own in 2013 and are fast providing new insights into the workings of single cells that ensemble methods are incapable of. Read more
Stephen Quake responds to a blog post by Lior Pachter that analyzes data from his recent analysis of single-cell RNA sequencing methods published in Nature Methods. Read more
The first gene patent was granted in 1982 for the sequence encoding insulin. Today ~ 20% of the human genome is patented. And the controversy is as alive as ever as we discuss in this month’s editorial. Read more
In our June issue scientists from Pacific Bioscience describe a method for direct sequencing of methylated DNA. To find an artistic expression for their work the authors put the sequenced DNA to music. Hugh Ash converted it into a trumpet solo. Read more
While the technology feature, “DNA sequencing: generation next-next”, was at press, Pacific Biosciences of Menlo Park, California stunned the community with their announcement of a single molecule sequencing technology they claim will provide a complete human genome in 15 minutes by the year 2013. Although Pacific Biosciences was founded in 2004, the company had been very ‘hush hush’ about their technology development. But that veil of secrecy was lifted during the Advances in Genome Biology and Technology meeting held February 6th to 9th at Marco Island, Florida where Stephen Turner, chief technology officer, presented the first preliminary data on the system. Read more
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Let’s give statistics the attention it deserves
Let’s give statistics the attention it deserves
Guidelines for algorithms and software in Nature Methods