Genome editing meets version control
Consider for a moment the logistics of rewriting a genome from scratch. Starting from a reference genome sequence, you nip and tuck, recode and reorganize. Changes to any one element changes the genetic coordinates of every element downstream, meaning the process requires consider genetic bookkeeping. Read more
Painting with yeast
Today, an international research team led by Jef Boeke of New York University Langone Medical Center and Joel Bader at Johns Hopkins University in Baltimore, Maryland, reported in Science a remarkable feat – the complete de novo synthesis and redesign of five yeast chromosomes, a first step towards a completely synthetic model eukaryote. Over at Nature News, Amy Maxmen has done an admirable job covering that achievement, part of a project called Sc2.0. What I’d like to talk about is one of the artistic flourishes used to illustrate it. Read more
#ScientistOnTheMove: February 2015
Claire Haworth and Oliver Davis, who both work in behavioural and statistical genetics, met whilst they were studying for a PhD at the MRC Social, Genetic and Developmental Psychiatry Centre at King’s College London and “managed to squeeze in getting married between submitting our PhDs and starting fellowships!” After graduating from their PhDs in the summer of 2009, Oliver started a Wellcome Trust funded postdoc in Oxford and Claire, funded by the MRS and ESRC, stayed in London. After her second fellowship Claire moved to the University of Warwick to set up her own lab and Oliver moved to UCL to start his own group in January 2013. Read more
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