The draft human genome sequence, announced with much fanfare in 2000, promised great insights into human biology, medicine and evolution. In a special in this week’s issue, whose content is free to read online, Nature asks whether the sequence has delivered the insights that were anticipated, and what lessons have been learned from the first post-genome decade. Human genetics in 2010 looks infinitely more complex, and questions about how to make sense of the explosion in biological data are only becoming more pressing. Read articles in Editorial, Features, Opinion (including articles by Robert Weinberg, by Craig Venter and by Francis Collins), Books & Arts, and News & Views, listen to our podcast and see past Nature collections.
What did the human genome mean to you? The availability of the human genome sequence shaped scientists’ lives and research in ways they could not have predicted. Help Nature gauge the impact of the sequence by taking part in a brief survey.
I’d like to highlight here Nature ’s Cell biology forum in the News & Views section: Genome-wide view of mitosis, in which Jason R. Swedlow on the one hand, and Cecilia Cotta-Ramusino with Stephen J. Elledge on the other, provide two complementary views on a paper in this issue of Nature describing an exceptionally large-scale project aimed at assigning function to all protein-coding genes in the human genome. This forum, in common with all other articles in this issue and all other issues of Nature, is open for your comments online. We look forward to reading what you think.