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Nature's latest Insight collection of reviews, Proteins to proteomes (Nature 450, 963-1009; 2007) is freely available online. Proteins are the most diverse and versatile set of biological macromolecules, having crucial roles in all biological processes. Now that whole complements of proteins (proteomes) for many cell types have been identified, we can begin to address the central question of how the innumerable protein functions are integrated so that a living cell interacts coherently with its environment. The Insight collection of five reviews covers vibrant areas of research in the 'protein world', journeying from single-protein dynamics, to functional proteomics and drug discovery, via new technological developments in structural, computational, evolutionary and cellular biology.
The Insight supplement is available here.

Posted by Maxine Clarke on December 17, 2007
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Nature Geoscience, whose first print/online edition will be published in January 2008, has published its first papers -- as advance online publications. Among these are a Commentary by Martin Visbek, "From climate assessment to climate services", who writes "If we fully embrace past assessment and ongoing future projections of regional climate change as the task of integrated climate services, the IPCC [Intergovernmental Panel for Climate Change] can be relieved of the duty of providing up-to-date assessments of climate change. This would allow the panel to move to the decadal assessments that best suit its primary task: reviewing emerging scientific knowledge and best practices to evaluate global climate change."
Also just-published are Letters by Parsons et al., on quiet zones in the San Andreas fault; and by Beerling et al. on cold intervals in the "greenhouse world" of the Mesozoic.
Nature Geoscience is accepting manuscripts that report new research in the Earth and planetary sciences, aimed at a broad interdisciplinary audience of geoscientists. View the complete Guide to Authors here. Submit your papers via the journal online submission system here.

Posted by Maxine Clarke on December 14, 2007
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Via email from my colleague Henry Gee:
Futures from Nature is an anthology of 100 very short stories from Nature’s award-winning back-page Futures SF series … and it’s published today [13 November 2007], as a hardback from Tor, at 25 [US] dollars (or about two bob on old money), so with the usual discounts, they’re practically paying you to take it away. It's the ideal festive gift for the constipated, insomniac trekkie in your life.
As well as stories from journalists, scientists and writers trying SF for the very first time, Futures from Nature is a parade of SF greats, featuring stories from the likes of Arthur C. Clarke, Frederik Pohl, Greg Bear, Gregory Benford, Kim Stanley Robinson, Dan Simmons, Alastair Reynolds, Charles Stross, Peter F. Hamilton, Vonda McIntyre and many more.
Here’s what Publisher’s Weekly said in their starred review: “Each vignette centers on a wondrous or devastating or simply mind-boggling what if, carried to an unsettlingly original logical conclusion—or left spinning in an extraterrestrial mental orbit… a perfect volume to awaken startling new thoughts on old SF themes, giant leaps into the future in delectably palatable tiny packages.”
Actually, I lied. The anthology doesn’t contain 100 stories, but 101. I wrote one extra, just for the book. Not that this alone makes the book an essential purchase, but, you know, every Greatest Hits package has to have its Bonus Track.

See here for the Amazon UK listing, and here for the Amazon US listing.

Posted by Maxine Clarke on November 13, 2007
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The need for data storage is enormous, and is expected to increase even further in the near future as new technologies such as on-demand television or high-definition video make it to the consumer. This Nature Materials Insight, published in the November 2007 issue, aims to capture the dynamic research efforts that span the wide range of related disciplines. The Insight is free online to registered users until 31 December 2007.
This Insight contains a collection of Review articles, together with a Commentary, that span the wide range of disciplines related to information storage. One of this year’s physics Nobel laureates, Albert Fert, reviews the recent advances in spintronics that, starting with his Nobel work, allow for dramatic advances in hard-drive technology. In an intereview, Intel’s Chief Technology Officer Justin Rattner talks about recent advances in microprocessor design. Find out more by viewing the Insight for free online.

Posted by Maxine Clarke on November 06, 2007
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"A decade ago, glia were the neglected stepchildren of neuroscience. Although glia outnumber neurons by about ten to 1 in the adult human brain, providing support for neurons has traditionally been viewed as their primary function. Glial biology has come into its own recently, as researchers have shown that glia are critical for the development of the nervous system and have key roles in various disorders." So writes Sandra Aamodt, Editor of Nature Neuroscience, in her introductory Editorial to the journal's focus on glia and disease (November 2007), which highlights recent efforts and discusses how advances in understanding glial biology may lead to new treatments.
Glial cells regulate brain vasculature and the blood-brain barrier, modulating ischemia and blood flow changes in response to neural activity. Moreover, they are important in brain repair after injury and contribute to neurodegenerative diseases. The Nature Neuroscience special focus on glia and disease contains four reviews and two perspectives that highlight recent research in these areas and discuss how advances in understanding glial biology may lead to new treatments.
The November issue of Nature Neuroscience is available online here.

Posted by Maxine Clarke on November 05, 2007
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Effective diagnostics are a crucial element of successful infectious disease management, yet their development and use, particularly in the developing world, remains a neglected area. To address this deficiency, Nature Reviews Microbiology is producing a series of user-friendly diagnostic evaluation guides as supplements to the journal.
The latest of these guides is now published, focusing on visceral leishmaniasis. You can access this guide free here.
This supplement is part of the Global Theme Issue on Poverty and Human Development, organized by the Council of Science Editors. All articles from Nature Publishing Group are available free. The content from all participating journals can be found here.
Robert G. Ridley, Director of the UNICEF/UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases, writes in his Editorial to the visceral leishmaniasis supplement (Nature Reviews Microbiology , S1; November 2007): "Apart from the lack of investment by public sector agencies and lack of commercial incentive, three major challenges in this field deserve highlighting. First, there is the scientific challenge to identify and develop diagnostic methodologies and techniques that can readily guide treatment. This is further complicated by the multiple Leishmania species that can cause VL [visceral leishmaniasis] and the multiple disease manifestations. Second, there is the challenge — addressed by this supplement — of ensuring effective and harmonized evaluation of diagnostic tests. Third, there is the need to develop regulatory controls that ensure appropriate evaluation of diagnostic tests before they come on the market and ensure sustained quality of manufacture and production, against defined standards, after they have been given marketing authorization."
The rest of the supplement is available here.

Posted by Maxine Clarke on October 31, 2007
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Are you interested in finding out more about research in Mainland China and Hong Kong? Take a look at Nature China. Every week, the editors of Nature China survey the scientific literature to identify the best recently published papers from mainland China and Hong Kong, and provide a summary of the results.

Divided into subject areas, this portal allows you to stay up-to-date with the latest research appearing in various scientific publications in this region. Taking materials science as an example, here some recent highlights posted on Nature China:

• Carbon nanotubes: Becoming a brighter fighter
• Drug delivery: Wet or dry
• Magnetic nanoparticles: Artificial enzymes
• Super-hard conductors: Electric diamonds

Other subject areas are: biotechnology; cell and molecular biology; chemistry; clinical medicine; developmental biology; Earth and environment; ecology and evolution; genetics; neuroscience; space and astronomy; and physics. You can register for Nature China e-alerts at the website, and stay abreast of the latest research in your field from mainland China and Hong Kong. Help us identify the best Chinese papers by using the recommended paper section of the website. Click here to recommend a paper and find out what papers other users have recommended.

Posted by Maxine Clarke on October 26, 2007
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A presentation and press briefing by Nature Publishing Group (NPG) was held at a high-technology fair in Shenzhen China on Friday 12 October, to announce and distribute the 20-page Spotlight and Regions advertising feature on Shenzhen published in Nature in the 27 September issue. NPG staff gave presentations on publishing activities in China to a packed audience of about 100 from academia, government, industry and the media. A reprint of the Spotlight translated into Chinese was released at the event.
Nature Publishing Group's Shenzhen Spotlight project has involved about 25 NPG staff and freelancers from around the world. David Swinbanks, NPG's publishing director in Tokyo, writes; "After three years of discussion, we were finally given the green light by the Shenzhen local government in early August and had to pull the 20-page feature together by 21 September for the 27 September issue so that copies could be made available at the China High Tech Fair on Friday." As the supplement is also fully online, this was a considerable achievement for all the writers, editors and project-managers involved.
Part of the Spotlight supplement includes a video of a self-pollinating orchid, which can be seen here in all its beauty, showing in a stunning way the incredible power of plant adaptation and evolution.

Posted by Maxine Clarke on October 23, 2007
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Milestones in DNA Technologies (October 2007) is a collaboration from Nature, Nature Methods and Nature Reviews Genetics, focusing on ground-breaking technologies and advances in the analysis of DNA. Developments in the last 50 years range from the first Sanger sequences to the latest next-generation chemistry, and from the earliest methods of DNA separation to transgenic organisms and specific gene replacement in human cells.
You can request a free print copy here. In addition, the full content of DNA Technologies, plus further articles and features, is freely available online from October 2007 for six months. The table of contents listing is here. You can also see here for a timeline of milestones in DNA technologies.
Index of all Nature Publishing Group's Milestones publications.

Posted by Maxine Clarke on October 19, 2007
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Articles in Nature Reports Stem Cells this month call for a return to nuance in the age of dogma. A pair of bioethicists worry that participants in clinical trials may hear "stem cell" and think "therapy", even without evidence of medical benefit. A stem-cell scientist describes his frustration at the fact-twisting practiced by proponents and opponents of embryonic stem-cell research. And a US presidential order strikes the term "embryonic" from the list of stem cell lines eligible for federal research.
Our top stories:
Therapeutic misconception and stem cell research
Mildred K. Cho and David Magnus from the Stanford Center for Biomedical Ethics worry that some advocates are making too good a case for stem cells' medical benefits.
Cancer stem cells, sightings and slightings
How rare are tumour-initiating cells? How relevant? Nature Reports Stem Cells asks whether the efforts to to identify cancer stem cells in one tumour after another might miss the big picture.
Alternative energy for pluripotent stem cells
Markus Grompe, the director of the Oregon Stem Cell Center, describes hopes and plans to create pluripotent stem cells without destroying embryos.
Stem cells by any other name
A funding crunch is forcing Singapore’s ES Stem Cell International to go after medium-term revenues.
Q&A: King of the stem cells
On 14 September, the California Institute for Regenerative Medicine (CIRM) appointed Australian biologist Alan Trounson as its new president.
Making the Paper: Embryonic stem cells make their own niche
By untangling the interplay of two growth factors, Mick Bhatia finds that stem cells in culture create ways to stall differentiation.
Nature Reports Stem Cells is a free, interactive forum for stem cell scientists and other stakeholders to communicate about the research, policy, ethics, business and medicine of stem cell science.

Posted by Maxine Clarke on October 18, 2007
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Subhra Priyadarshini writes:
In keeping with the increasing global interest in Asia, Nature Publishing Group (NPG) will launch its India-specific website Nature India next month. Nature India aims to be the one-stop site for information on Indian science. The website, serving the scientific community of the world's largest democracy, will have a potpourri of content such as jobs, events, research highlights and science news from India. In addition, it will attempt to capture India's rapidly changing scientific and economic scene and her globalization. Through in-depth features and commentaries, leading members of the science community will reflect on contemporary issues affecting Indian science.
Readers will also have free access to some handpicked premium content from various NPG journals. Nature India will host a number of interactive sections — recommended papers, our 'Indigenus' blog, and a Nature Network forum where peers can network or indulge in a leisurely chat.
In terms of design, Nature India attempts to be just as vibrant, colourful and boisterous as the people of this magical land. Be among the first to explore India through its cutting-edge scientific pursuits.
Sign up for our regular Nature India e-alert, and we will send you your first newsletter when the site is live.

Posted by Maxine Clarke on October 17, 2007
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For those interested in specific groups of organisms, we have arranged the large-scale biology papers published at Nature Publishing Group into a "Tree of Life" organization at the Omics Gateway, so that you can browse among the organisms. Papers that focus on a single species can be found in the most exclusive organism page that includes that species: for example papers on humans will appear on the human page rather than the primates or mammals page. Papers that focus on, or are relevant to, multiple species can be found in the set of pages that encompass those species: for example a paper that compares the dog genome with the human genome will appear on both the human and mammal pages. Categories listed on the gateway and in the picture include animals; archaea; arthropods; bacteria; chordates; eukaryotes; firmicutes; fungi; green plants; human; mammals; metagenomics (genomics of microbial communities); nematodes; primates; proteobacteria; rodents and viruses.
As well as browsing organisms, you can also browse subjects at the Omics Gateway. Why "omics"? It is a suffix that has been added to many fields to denote studies undertaken on a large or genome-wide scale. While not everyone agrees with this change of terms, it is a short and inclusive term to use to help point you to our published papers in the area. For example although we may not yet be able to precisely define the metabolome, we can all appreciate that studies in this area should yield novel insight into the processes that drive cellular metabolism and detailed interactions between them. Papers here come from publications throughout Nature Publishing Group in one or more of the subject areas of: cancer genomics; chemical genomics; comparative, evolutionary and population genomics; epigenomics; genetics of gene expression; genome sequence and analysis; glycomics; metabolomics/nomics; pharmacogenomics; proteomics; systems biology; techniques and methods; and transcriptomics.

Posted by Maxine Clarke on October 16, 2007
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Cell Migration Update, a part of the Cell Migration Gateway, is a one-stop online resource designed to keep you in touch with the latest and hottest research in cell migration, by Nature Publishing Group in collaboration with the Cell Migration Consortium.
Each month we showcase two exciting new cell migration articles from the current literature. Nature Publishing Group papers are available free for 3 months, and the Editor's Reviews are free indefinitely.
This month's selections:

Par-Tiam1 complex: Persistently on Par
Tiam1 and the Par polarity complex control cell polarity, chemotaxis and persistent cell migration of epidermal keratinocytes by affecting microtubule stability.
Curr. Biol 9 Oct (2007).
Editor's Review is here.

Integrin adhesiveness: May the (shear) force be with you
Immobilized chemokines promote T-lymphocyte migration in a shear stress-free environment, but induce integrin activation and adhesiveness in the presence of external shear forces.
Nat. Immunol. 8, 1076-1085 (2007)
Editor's Review is here.

See also this month's Cell Migration Gateway research highlights, research library, latest news and conference calender.

Posted by Maxine Clarke on October 10, 2007
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A reminder to Nautilus readers that Nature Protocols Volume 2 is open access to the end of this month. So far, there more more than 250 protocols in the volume -- please visit Nature Protocols and check them out for yourself.
Whether you want help with an experimental technique, or can offer advice on the questions already posted, please join in the debate on the free Nature Protocols discussion forum on Nature Network. There are currently 26 topics in the forum, with many questions and answers, on subjects including insoluble proteins, mitochondrial DNA from plants, immunoglobulin and other protein purification, large cloning fragments and hydrogen peroxide detection.

Posted by Maxine Clarke on October 09, 2007
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October 2007 marks the first anniversary of the launch of Nature Nanotechnology. To celebrate, the editors have put together their highlights from the first 12 issues. The selection, which is available free until December 2007, reflects the diversity of nanoscience and technology, including contributions from chemists, physicists, materials scientists, engineers, biomedical researchers and others. We hope that you will enjoy browsing through the list, and join us in looking forward to an enjoyable, informative second year.
Nature Nanotechnology first-year highlights.

Posted by Maxine Clarke on October 02, 2007
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The world's population is ageing rapidly. The effects of this change in demographics are predicted to touch on many facets of human life. Not least, because the health of older people deteriorates with time. Nature's latest in its "collections" series draws together recent articles on the process of ageing, and the connections that exist between growing older and disease.
You can read the collection online, where it is free-access, or order a free print copy.
A collection of articles on the same subject, the Nature Reviews Molecular Cell Biology web focus on ageing, can be seen here.

Posted by Maxine Clarke on September 28, 2007
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October 2007 marks the 50th anniversary of the publication in the Australian Journal of Science of Frank Macfarlane Burnet's clonal selection theory, an intellectual framework that revolutionized the field of immunology.
Nature Immunology celebrates the event in an editorial (Nature Immunology 8, 1009; 2007) and a historical Commentary by Philip Hodgkin, William Heath and Alan Baxter (Nature Immunology 8, 1019-1026; 2007). Accompanying this Commentary is the two-page manuscript from the Australian Journal of Science in which Frank Macfarlane Burnet presented clearly for the first time the ideas that underlie the modern science of immunology (reprinted with permission from the Australian and New Zealand Association for the Advancement of Science).
Nature Reviews Immunology celebrates the achievement by a Viewpoint article in which Melvin Cohn, N. Av Mitchison, William E. Paul, Arthur M. Silverstein, David W. Talmage and Martin Weigert, scientists working or who have worked in the field, provide their thoughts and opinions (Nature Reviews Immunology 7, 823-830; 2007).
From the Nature Immunology historical Commentary:

Rarely has a field as large and influential been gathered together and encapsulated in so spare a form. The modern reader can still appreciate the paper's brevity, clarity and masterly exposition of scientific method. It is worth rereading not only for its significant historical importance, but also because we see the individual creative scientist at work. Burnet's personal ambition to solve the problem of antibody specificity is clear, and he leaves plenty of clues for us to trace the evolution of the ideas that led to his solution and identify the colleagues who helped in its formulation. There is also mystery associated with the paper, such as why it is in such an obscure journal and what David Talmage's impact was on Burnet's ideas. Speculation on these issues has kept interest in the paper high over the decades.

Posted by Maxine Clarke on September 27, 2007
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Nature Neuroscience presents a special focus on emotion and emotion disorders, published in the September 2007 issue and accessible online. Regulation of emotion is becoming better understood, but despite the societal costs of disorders like depression and anxiety, their causes remain unclear. Five review articles in this issue provide perspective on this literature.
New insights into BDNF function in depression and anxiety
Keri Martinowich, Husseini Manji & Bai Lu
Social learning of fear
Andreas Olsson & Elizabeth A Phelps
Long story short: the serotonin transporter in emotion regulation and social cognition
Turhan Canli & Klaus-Peter Lesch
Adult hippocampal neurogenesis in depression
Amar Sahay & Rene Hen
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Kerry J Ressler & Helen S Mayberg

Posted by Maxine Clarke on September 21, 2007
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Nature Clinical Practice (NCP), the medical publishing arm of Nature Publishing Group (NPG), has announced that NCP Cardiovascular Medicine will accept clinical and translational original research, starting this month (September 2007). The journal is consdiering submissions of original research papers in the areas of randomized, controlled trials; systematic reviews/meta-analyses; observational studies; epidemiological studies; and translational studies -- as well as timely and succinct analysis of recent advances. The journal's online submission site for original reserach papers is here; or you can email the journal for further information.

Posted by Maxine Clarke on September 20, 2007
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To mark a decade of significant progress in the increasingly important discipline of marine microbiology, the October issue of Nature Reviews Microbiology features a special focus on the topic.The issue contains a collection of articles that highlight the latest advances in marine microbiology and how they are leading to a new understanding of biodiversity, ecology and biogeochemistry. The topics covered range from recent advances in our understanding of marine ecology and metagenomics to the remote sensing of microorganisms and ecological modelling. This issue also features the marine viruses that are believed to shape microbial ocean communities, and addresses the question of microbial abundance in the extremely harsh conditions of the deep ocean biosphere.
From 13 September 2007, these articles are available free to download owing to the generous support of the Gordon and Betty Moore Foundation and the Agouron Institute. This special issue is also accompanied by a Web Focus that draws together relevant articles published in journals across the Nature Publishing Group.

Posted by Maxine Clarke on September 17, 2007
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Nature Geoscience, to launch in January 2008, now has a preliminary website. In its call for papers, the journal states that it is accepting submissions of manuscripts reporting significant new research in the Earth and planetary sciences, aimed at a broad interdisciplinary audience of geoscientists. Read the Guide to Authors and submit your papers via the journal's online submission system.
Also on the "pre launch" website are research highlights: short summaries of key research papers in the discipline, written by the journal's editors. You can expect to find several new research highlights per week between now and the journal's launch in January. The editors are also busy commissioning review articles and processing the many manuscripts that have already been submitted to the journal. Vist Nature Geoscience for information about how to subscribe and other news about this exciting new publication from the Nature journals.

Posted by Maxine Clarke on September 10, 2007
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The latest in the Nature Collections series is on energy. The most pressing technological problem facing the world is uncoupling the provision of energy from the net production of carbon dioxide. This collection outlines the promises and pitfalls of new energy technologies. It looks at the potential of biofuels and nuclear power, explores new ways to lock away CO2, and considers renewables such as solar and wind power. The collection is freely available online, or you can request a free print copy here.
You can see the rest of the Nature Collections series here.

Posted by Maxine Clarke on September 04, 2007
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The Journal of Investigative Dermatology now has a journal club group on Nature Network, a place to read, discuss, and learn more about cutting-edge research in cutaneous biology. Anyone can join Nature Network simply by registering for an account. It is all free, and once you've joined, you can join the Journal of Investigative Dermatology's or any other group from the large range that have been set up by users. You can also participate in the forum discussions or set up your own blog on the Nature Network -- the place for scientists to meet, communicate and socialise.

Posted by Maxine Clarke on August 20, 2007
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We are delighted to announce the launch of a new journal, Nature Chemistry, in the first part of 2009. Alongside the highest-quality original research, Nature Chemistry will cover news, commentary and analysis from and for the chemistry community, as well as striving to develop a voice that chemists care about.
Over the past five years, Nature Publishing Group (NPG) has expanded its portfolio of Nature journals in the physical sciences, with Nature Materials, Nature Physics, Nature Photonics and Nature Nanotechnology.
Nature Chemical Biology marked NPG's first major foray into chemistry publishing. Launched in June 2005, Nature Chemical Biology has established itself as the home for primary research covering the interface between chemistry and biology. Its first impact factor is 12.409, making it the number one primary research journal in related chemical sciences.
Nature itself has also expanded its coverage of chemistry, with the addition of several chemists as editors to select papers for publication and to report news on chemistry in the News and Views and News sections of the journal.
We have also created additional online services and publications, such as the Sceptical Chymist blog, chemistry podcasts, a chemistry subject area, and our bi-monthly chemistry e-alert about what is new for chemists and chemistry. We also regularly provide hundreds of job opportunities for chemists via naturejobs.

We are looking for a Chief Editor who is able to develop, launch and establish Nature Chemistry as the essential publication for the chemistry community. The role will be based in NPG's Boston office.
Applicants must have a strong track record of research in a chemistry discipline, as well as significant editorial and/or senior research experience. They must demonstrate a good understanding of the challenges faced by researchers in both academic institutions and industry.
This is a demanding and extremely stimulating role, which calls for a keen interest in the practice and communication of science. The successful candidate will therefore be dynamic, motivated and outgoing, and must possess excellent interpersonal skills.
Applicants should include a covering letter stating their suitability for this post, as well as their salary expectations, a current CV and a statement (maximum 1,500 words) that encapsulates their vision for the content, competitive position and longer-term development of Nature Chemistry.
Applications should be sent to Denise Pitter, Personnel Assistant at londonrecruitment@macmillan.co.uk. Applicants should clearly mark on their submissions the reference number. Incomplete applications will not be considered. Closing Date: 24 September 2007

Posted by Maxine Clarke on August 16, 2007
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The July issue of Molecular Systems Biology, NPG's open access journal published in partnership with EMBO (European Molecular Biology Organisation), is live. This month's featured article is Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli, by Robert Schuetz, Lars Kuepfer & Uwe Sauer (Molecular Systems Biology 3, 119; 2007), with an accompanying News and Views article by Jens Nielsen (Molecular Systems Biology 3, 126; 2007). See the journal's home page for more research papers, News and Views, Perspectives and Editorials, as well as links to systems biology papers published in the Nature journals.

Posted by Maxine Clarke on July 25, 2007
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The July Editorial in Nature Structural & Molecular Biology (14, 569; 2007) reports on an interesting and diverse Cold Spring Harbor meeting on "clocks and rhythms" that reminds us of the importance of supporting basic science research.

From the editorial: "many presentations began with an image of the Earth seen from space, half shrouded in nocturnal shadow (no, this wasn't a sci-fi convention). Another unusual feature was the curious mix of scientists—biochemists, microbiologists, fly and mouse geneticists, plant biologists, neurobiologists, clinical researchers—all mingling and discussing their work. Even for a seasoned conference-attending editor, this was quite a remarkable gathering.

Read on at the NSMB journal page.

Posted by Maxine Clarke on July 23, 2007
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