Personal GenoME & Medicine: Hype or Reality? So runs the title of the next Talkscience evening at the British Library in London on 23 September. As usual, there is a Nature Network forum to provide more details of the event and to start the discussion going online before the meeting itself, so readers are encouraged to check that out and contribute ideas. How is cheaper, faster DNA sequencing helping or hindering our ability to understand disease, treatment and prevention? Which of the many single-nucleotide polymorphisms that have been identified in genome-wide association studies might be causal to a disease? How will advances in genome technologies lead to better diagnosis and treatments? What are the legal, ethical and other issues concerning “direct to consumer” personalised genomics?