Presubmission enquiry or entire manuscript?

Q: Dear Nature: I am considering sending a presubmission enquiry for a Letter, and in the process, noticed your comment that, “The editors would prefer to read the full paper even if it isn’t in journal format, than to read a presub.” If, (hypothetically!) I had a paper written in the format of another journal which that journal has not offered to publish, is there a mechanism by which I could submit this paper, rather than a presubmission enquiry, to Nature with the understanding that it would be rewritten to conform to your format if it were to be formally submitted? Would this be preferable? It would certainly be easier for me, and presumably would give you better information. 


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