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    Christine Micheel said:

    Thank you for this post. There is an error that should be corrected. No one named Dan Foley was on the IOM committee. Dan Hayes from the University of Michigan was a member of the committee and a speaker at the AACR session, perhaps this is something he said? The IOM committee roster can be viewed at http://iom.edu/Reports/2012/Evolution-of-Translational-Omics.aspx by selecting the “View Full Committee” option on the right-hand side of the screen.

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    Jim Woodgett said:

    Are these findings surprising given the well understood nature of the instability of tumour genetic integrity? Once tumours have sufficiently compromised their DNA repair processes, their rates of mutation are significantly elevated and heterogeneity is bound to increase. We also know that selective pressure (acquisition of drug resistance) can cause watershed shifts in cell populations, allowing new populations to emerge and dominate. Tracking these shifts should yield important prognostic information, unless genomic integrity is shot, at which point using precision tools is likely a wasted effort. Expansion of deep sequencing of genetically unstable tumours will undoubtedly generate reams of data. However, documenting the precise shapes of clouds on one day does not help predict the shapes the following day, or the next.

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      Paul Morrison said:

      However, documenting the precise shapes of clouds on one day does not help predict the shapes the following day, or the next.

      I’m going to have to borrow that, thanks.

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