Our August issue went live last week; check out the Research Highlights section for a few "news" stories about interesting new methods described in the literature over the last month or two. Unfortunately we cannot highlight every interesting methods paper we find in the pages of the journal, so check out some of the others we considered that didn't quite make the cut.

Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture
Nature Biotechnology 27, 557-559 (2009)

Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing
Science 324, 1210-1213 (2009)

Validated germline-competent embryonic stem cell lines from nonobese diabetic mice
Nature Medicine 15, 814-818 (2009)

Unfolding Individual Als5p Adhesion Proteins on Live Cells
ACS Nano, 3, 1677-1682 (2009)

Development of aliphatic biodegradable photoluminescent polymers
PNAS 106, 10086-10091 (2009)

Directing cell motions on micropatterned ratchets
Nature Physics 5, 606-612 (2009)

Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding
Genome Research, published online 22 June 2009

Twin-spot MARCM to reveal the developmental origin and identity of neurons
Nature Neuroscience 12, 947-953 (2009)

The establishment of gene silencing at single-cell resolution
Nature Genetics 41, 800-806 (2009)

DNA relaxation dynamics as a probe for the intracellular environment
PNAS 106, 9250-9255 (2009)

Interactive exploration of chemical space with Scaffold Hunter
Nature Chemical Biology 5, 581-583 (2009)

Bioactivity-guided mapping and navigation of chemical space
Nature Chemical Biology 5, 585 - 592 (2009)