Minimizing the risk of reporting false positives in large-scale RNAi screens
A group of investigators from various institutions have written a Commentary in which they articulate their experience about caveats of large-scale RNAi screens. These authors propose that the use of standard controls should be adopted across the community of RNAi users to minimize the risk of reporting false positives among screen results.
Far from trying to dictate rules, this Commentary seeks to open a community-wide discussion leading to a consensus of best practices that can realistically be implemented across all experimental settings. Therefore, we welcome your reactions and hope for a constructive dialog for the benefit of all. Please post your comments below.
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