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Big Pharma and academia becoming more and more cozy

I recently attended the Alzheimer's Disease Keystone meeting in Keystone, CO and became more acutely aware of something than ever before: academia and drug companies really like one another. Sure, the latter always loved the former, since collaborating with university-based scientists often made the publications arising from the private sector look a little more legit. On the contrary, the reciprocity in this relationship has not always been there. There is without a doubt some sub-disciplinary differences in this complex relationship, but in the basic science departments that I lurked around, if you were associated with a company (or worse, left academia for a position there, succumbing to the power of the Dark Side), there was always talk of whether or not you could be trusted. Because companies need publications to prove the legitimacy of their product, right? And the legitimacy determines how much money everyone makes, right? So with such conflicts of interest, could the scientist, or the data being produced by these people, be trusted?

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What to do with your unfunded proposals - place them in a centralized repository?

I would say no. Grant proposals are a precious commodity, especially in this day and age of reduced funding and evaporating money. However, in a recent Nature correspondence, Dr. Noam Harel describes his vision for a centralized grant repository, ideally open to the public, where researchers could place their best ideas, allowing various funding agencies to discover the plans most-suited to their respective agendas. Dr. Harel likens this potential web manifestation to something like eBay, Facebook or Google, but for scientists and funding agencies. A more apt analogy might be Monster.com, with both sides searching for their ideal match, and a long-term relationship (perhaps I am now making it sound more like eHarmony.com...).

When it comes to the integration of scientific communication and technology, I am extremely optimistic, and although I don't reject Dr. Harel's idea entirely, I just don't see it taking off in its presently-proposed form.

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Haihong Ye: Amazing changes in Chinese neuroscience over the past decade

[This is the inaugural post for a new feature at Action Potential. Periodically, we will provide insights from a regional correspondent on the interesting news, changes, or issues particularly affecting neuroscience in a particular location. Today's post is from one of our Asian correspondents, Haihong Ye of the Institute for Biophysics in the Chinese Academy of Sciences. She reflects on the dramatic changes that have occurred within Chinese neuroscience during her decade-long absence from this now-flourishing community. We examined these issues in our March editorial, but now invite you to provide your opinion. - N.G.]

Over the past 10 years, especially the last five, the whole world has been amazed by the Chinese economy. To me, however, the improvement in biological science research in China is much more amazing. In the summer of 1998 I left Beijing and went to the US to pursue a Ph.D. in neuroscience. In 2007, after nine years of graduate study and post-doc training abroad, I came back to Beijing, seeking opportunities for further career development. What a difference some strong funding and visionary directives, not to mention a decade, can make.

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Neuroscience and Web 2.0: Participation may vary

In the last couple of years, after the recent explosion in the number of resources where scientific discussions can take place rapidly and without boundaries (i.e., using the internet), one could easily have predicted that we were on the cusp of a revolution; the way in which scientists communicated with each other regarding data was about to change forever. Although poster session chatter at your favorite scientific meeting was never going to be replaced, now researchers could interact, trade ideas and get feedback from anyone, anywhere, at any time. Sounds pretty good, right? Unfortunately, it doesn't seem like neuroscientists are taking advantage of these cool new offerings. I could extrapolate to biology in general, but for more simplicity (and other obvious reasons), let's stick to what we know best.

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Pet sematary

A woman in the US has decided that she loved her pit bull (named Booger) so much, that having him all over again is definitely worth the $150,000 price tag. I saw this story in the BBC, reporting how a Korean company, RNL Bio, has taken its initial order for pet dog cloning, the first such venture of commercial scientific canine cloning (a pet cat was first cloned in 2004). The lead scientist at RNL Bio, Dr Lee Byeong-chun, had previously worked with disgraced stem cell scientist Dr Hwang Woo-suk, whose fraudulent publications created quite a stir (we referred to that scandal on Action potential here.)

The client, Bernann McKunney, gave RNL Bio ear tissue from "Booger", preserved by an American biotech firm before the dog died 18 months ago. Ms. McKunney had become quite devoted to her dog after she claimed it saved her life, coming to her aid while she was being attacked by another dog, an encounter that cost her an arm. For those of you wishing you had the six figures required to re-create your close canine companion, never fear, RNL Bio's marketing director, Cho Seong-ryul believes that the cloning costs should come down to be under $50,000, as the industry begins to "take-off".

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What are you doing for Darwin Day?

The Darwin Day celebration was initiated by Dr. Robert Stephens and was held at Stanford University on April 22, 1995 to celebrate the scientific accomplishments of Charles Darwin. In subsequent years, the event was changed to be on or around the birthday of Darwin (February 12, 1809) and has had many illustrious speakers take part, including Richard Dawkins and Donald Johanson. The celebration has become a global one, with museums, academic institutes, private foundations, and others sponsoring some form of a tribute to this famous scientist.

A consolidated list of this year's events, held around the world, is here. Tell us what you plan to do on Darwin day, and if you take part, report back here on what you learned, disagreed with, or experienced. If we get a nice response here, perhaps we can prepare an event synopsis for ARJ, in case their readers miss out on the celebration.

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Easing back into it

Well, now, it has been a nice long break since the last post, but time to get this blog rolling again here in 2008. Let's start light, while I finish cooking up the stuff I want to discuss. Let's return to a request I buried in a previous post that received no response:

With regards to moving on, I have plenty of ideas for new discussions, but would also like to offer up the concept of "reader-generated content." If I receive enough participation, I'm willing to discuss what you find interesting as often as you send me promising topics. For now, let's set the modest goal of one reader-selected topic every 2 weeks, and go from there. If you would rather keep your communications and ideas private, feel free to email me at 'Actionpotential' at natureny dot com.

This can take any form, including a nomination for a new study that you think might stimulate conversation, or for clarification on a Nature Neuroscience paper that was recently published (I especially encourage the non-scientist readers to take us up on this offer!).

In addition, if you haven't noticed, we have been working on a modest facelift of the blog homepage, with more organization and categorization. I'd love to hear any feedback on any of these new aspects and will take any other suggestions that might make the blog more user-friendly. Here's looking towards a captivating survey of neuroscience in 2008!

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Open Laboratory 2008 - last call for submissions, but I'll just take your comments

Science blogging is becoming a fairly large entity, if you haven't noticed. NPG alone sponsors seventeen of them. Launched in January 2006, Scienceblogs.com has had over 50,000 posts and 555,000 comments on 66 blogs. This is a good thing for both the general public and for science, as again the internet proves its worth by easily bringing together populations of people who may have only rarely mixed otherwise.

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Notes from Action Potential's far-flung correspondents

Well, it's the last day of the meeting and time to start sharing what you have learned. I invite all SfN attendees to comment on an interesting talk, poster, experience, etc... that they had or saw at the meeting. I'd like to take advantage of this forum to get an interesting discussion going regarding anything from specific research findings, science policy, or gossip. Questions are also welcome. To get the ball rolling, I am going to repeat a comment here that was submitted under the previous blog entry, from Dmitry:

In case you also are at the SfN conference and were present today on a wonderful talk by Gazzaniga, I've got one stupid question. He finished by telling some story about his son losing a row competition and it was supposed to be an advice for young scientists. Unfortunately I didn't completely get the point (because of my English not being perfect). Could you briefly retell it?

If anyone can help out, it would be appreciated. So let's have it, I'm interested in hearing your thoughts from the meeting.

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CSHL neuroscience is shrinking

Although the Watson scandal was more public and hit faster, there has been another crisis brewing at CSHL for going on a year now that has been discussed in whispers at meetings and through emails, but let's organize all of these free associations and questions into a single place and ask the big question:

What is going on with neuroscience at CSHL?

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Paranoia in research – justified or not?

I just returned from attending my second Gordon Research Conference in two months and I am surprised by what I have seen and heard. Or should I be? Gordon Research Conferences (GRC) were started in the 1920's by Dr. Neil Gordon of Johns Hopkins University as a means to foster direct communication between scientists working in specific disciplines. The "spirit" of the GRC was to present unpublished data, making the meeting a cutting edge presentation of the latest and best findings from top laboratories. These days, one is considered a cavalier presenter if your talk includes data that are mere days from being accepted for publication, let alone including novel findings that are provocative, but may not as of yet be fully developed, and nowhere near ready for submission to a journal.

I am all for presenting older results, as some recent historical perspective often enriches the understanding of any new findings that are presented. This "review" also helps to educate the students and post-doctoral fellows attending the meeting, the conferees most likely to be less familiar with the history of the field. But I didn't see any chances being taken at the meetings that I attended, which likely reflects the nature of scientific research today, at least in particular disciplines. With academic positions few, the number of PhD-holding ambitious young scientists many, I guess I can't blame presenters for hoarding their most precious findings, so as to protect them from the "vultures" looking for the next great idea to pursue, or experiment to conduct, ready to call the kidnapped results their own intellectual property. However, this policy of data protection is bad for science and can transform a meeting into a delicate social interaction where one never knows if the person to whom he/she is talking will be the one to run back and duplicate a result, rushing to publish it quickly (unfortunately, given the competition of today, being the first to publish a key result may make the difference between getting tenure or finding a new job and home.) Therefore, the intellectual exchanges that are the hallmark of small meetings, and often the source of the best criticism for one’s work, are severely dampened.

I think that Dr. Gordon would be disappointed if he saw that his vision of small, intimate, cutting-edge meetings where scientific ideas can flourish and intermix had digressed to a state that differs little from the stereotypical large meetings (like SFN) where novel, unpublished findings are a rarity. For the record, here is the mission statement of the GRC:

"The Gordon Research Conferences provide an international forum for the presentation and discussion of frontier research in the biological, chemical, and physical sciences, and their related technologies...placing a premium on the "off the record" presentation of previously unpublished scientific results and on the consequent ad hoc peer discussion."

It is sad that our intellectual pursuit of knowledge through scientific research has become just like any other business venture...cut-throat, stressful, with a healthy dose of paranoid conservatism attached to everything. And to think, in my undergraduate naivety, I thought that by going into science I was going to avoid the abuses and misadventures that came with pursuing a career in corporate America.

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The stem cell debate continues...

Let's move the debate from an earlier thread in a different direction, as I am getting a bit bored by that discussion. By the way, for those keeping score, Dr. Condic's response to the editorial in question was published in the July issue of Nature Neuroscience, and went live today.

Last week, President Bush vetoed another bill that would have allowed research on embryonic stem cells to go forward in America. Is Bush reflecting the current opinion of the country? A recent USA Today/Gallup pool says that he is not. Between 4/13/07 and 4/15/07, the poll asked 1,007 adults nationwide this question: "As you may know, President Bush has said he will veto a bill to expand federal funding for embryonic stem cell research. Do you think Bush should or should not veto this bill?" 31% said that he should, 64% said that he should not, while 5% were uncertain. In another recent poll published last week in Science , 60% of infertility treatment patients (over 1,000 in the poll) stated that they would prefer to have their unused embryos used for research purposes rather than having them destroyed or adopted by another couple.

Thus, it seems that the minority opinion is currently ruling on this issue, as it has for quite a long time. In fact, in all polls I could find dating back to 2001, when any group of people were asked if the federal government should support embryonic stem cell research, a majority always answered yes. So let me play the devil's advocate for a moment; since President Bush was elected twice, this begs the question of how relevant the debate over stem cell research really is in the mind of the average voter! Where do you think this debate sits on the political front? Is this even one of the most critical debates pertaining to federal scientific funding? I'd love to hear your opinions.

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