Nature Medicine | Spoonful of Medicine

Doubts about usefulness of gene testing for antiplatelet drug prompt video rebuttal

A textbook example of pharmacogenomics is the testing of the CYP2C19 liver enzyme gene to predict how well people will metabolize the antiplatelet drug Plavix (clopidogrel). Many cardiologists have such confidence in the link that they preemptively genotype people before administering the drug. Last year, US regulators even added a ‘black box’ warning to clopidogrel’s prescribing information noting the the link between certain genotypes and reduced drug efficacy. But a new meta-analysis published in the Journal of the American Medical Association (JAMA) this week reports that such preemptive moves might be premature. 

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