Nature Medicine | Spoonful of Medicine

Study challenges genetic conventions in personalized medicine

A more refined genomic approach to personalized medicine could make drugs such as statins safer for patients, the authors of a new paper recommend. Hospitals increasingly use genetic testing to determine whether people are at risk for developing toxic levels of certain drugs in their bloodstreams due to common genetic variants that cause slower clearance of medication by the liver. A study published today in Genome Research strengthens the case for health providers to incorporate tests for rare variants that also influence how the body clears medications from the blood. The study focused on the medication methotrexate, used to treat 

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