The Niche

Do induced pluripotent stem cells arise from skin stem cells?

In June, widely publicized work from three labs showed that specialized cells could be reprogrammed after transfection with four genes. In this correspondence, James Trosko suggests an alternative explanation, that the reprogrammed cells identified by groups led by Shinya Yamanaka, Rudolf Jaenisch, and Konrad Hochedlinger and Kathrin Plath could in fact be skin stem cells reprogrammed to an embryonic state. 

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