The Niche

PTEN lessons from planaria

This one is by freelancer Simone Alves. We’ll have it up on Nature Reports next Thursday. PTEN (phosphatase and tensin homolog) is an important tumour suppressor in humans, and its disruption contributes to a wide variety of cancers. The fact that it appears to negatively regulate the PI3K/Akt pathway, which controls cellular proliferation and differentiation, implies that it is important in adult tissue homeostasis; however, until now, its role in this process had not been fully explored. A study published this week in Disease Models & Mechanisms, from Alejandro Sánchez Alvarado at the University of Utah, in Salt Lake City, 

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