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March 31, 2007

ACS: Slow writer (part 2), or, Nature will find a way...

The extra challenge (for me and other chemical biologists or biological chemists or what have you) of the spring ACS meeting is that the biological section basically closes down. This year, the entire program was 5 sessions, which were actually all sponsored by another division. So while, at the fall meeting, it's quite easy to scoot around between enzymes, folding, imaging, etc. within a few pages of the printed program, the spring meeting requires some extra work to find sessions dealing with biologically-related questions.

Don't fret, though - the scientists who want to talk about these things are still a part of the meeting, and can be discovered in nooks and crannies of the other divisions. Kind of like how rampaging dinosaurs will figure out a way to overcome their female-only DNA to take over the world. Or, to imagine a different definition of that infamous line (in my blog title, you know), perhaps I mean that us Nature editors will still be able to locate these hidden sessions.

That last idea was certainly true for a great program put on by the CHED division, focused on 'Exploring and Exploiting Nature with Biomimetics'. Not only was this program part of an unusual division,* but it was set in a room in the basement of the North/South building at the end of a hall and around a corner, etc. Too bad there wasn't also a wardrobe to climb through to reach this magical land of graduate student-invited talks. I didn't get to see as many of the talks in these three sessions as I would have liked, but they were full of the heavy hitters in the field, including, for example: Ron Breslow, Julius Rebek, Larry Que Jr., Paul Wender, Laura Kiessling, Dirk Trauner... the list goes on and on. Wender gave a nice talk about function-oriented synthesis, in which the complexity of natural products is pared down to the minimum functionality required. In addition to simplifying the synthesis of these molecules, he suggests that we can use this process to better understand the function of the molecule, allowing the design of new (and even simpler) compounds. Eric Kool, on the other hand, is all about making things more complex. He is designing an orthogonal genetic system based on xDNA (expanded DNA, in which each base contains an extra ring). Once that works, maybe we can design some xDinosaurs?

Anyway, congrats to the graduate students for putting together such a great lineup. And now, I've mixed up enough pop culture references for one day.

Catherine (associate editor, Nature Chemical Biology)

* To be fair, the sessions were cosponsored by the Biological division, so I didn't have to look that hard.

March 30, 2007

Reactions - Mike Zaworotko

1. What made you want to be a chemist?

Chemistry was always my favorite (but not always my best) subject in grammar school, probably because the practical applications of chemistry in everyday life are so tangible. To this day I remain fascinated and motivated by the opportunities and challenges offered by chemistry and how the practical relevance of basic research can lead so quickly to an application.

2. If you weren't a chemist and could do any other job, what would it be - and why?

I cannot now imagine being anything other than a chemistry professor. There were times when parental or peer pressure might have pushed me towards teaching, industry or medicine. Based upon what I know now, these careers would probably have not worked out for me. However, if there was a fork in the road, it was when I was a teenager, since my best subject in grammar school was geography. Ironically, I have ended up seeing much more of the world than I could ever have imagined when I took the fork towards chemistry. My numerous visits to so many parts of the world have, in a way, made me an amateur at studying the chemistry of people.

3. How can chemists best contribute to the world at large?

Chemists can, must and will play a major role in solving the global challenges we face with the environment, energy and human health. In my opinion, if there is one thing we could do better in this context, it is to work less as individuals and more as teams. The grand challenges are simply too large and complex for an individual chemist or even a group of chemists to address, never mind solve.

4. Which historical figure would you most like to have dinner with – and why?

A very difficult question. Historically, it would probably be Leonardo da Vinci, whose impact on art and science and even today’s culture was and is so immense. The living person I most admire is Nelson Mandela.

5. When was the last time you did an experiment in the lab - and what was it?

Yesterday. I still like to grow crystals and have never lost the excitement of solving crystal structures and I am apt to conduct a few experiments per month. If we ever figure out how to predict a crystal form before it is made then the excitement might lessen, but we are not there yet despite over 100 years of X-ray crystallography. However, I do not spend time in the lab every day, which is just as well for the students.

6. If exiled on a desert island, what one book and one CD would you take with you?

The Foundation Trilogy would be my book choice. In terms of music, I download (legally) individual tracks and have not bought a CD at a store for years. I would select a home-made CD which contains 20 tracks that represents a mix of the 60-90s (my selection of Beatles, Motown, U2, Cat Stevens, Eagles, Stones and, maybe, a track or two from Dark Side of the Moon).

Mike Zaworotko is Chair of the Department of Chemistry at the University of South Florida and works on crystal engineering, the design and application of functional solids, with particular emphasis on the design of porous and pharmaceutical materials.

ACS: Slow writer (part 1)

Well, I've never been one to follow the trend, so I decided to write about the ACS after it was actually over. Forget this real-time blogging stuff! (and if you're only reading this blog for the ACS content, keep reading for the next few days).

I wanted to offer my congratulations to Drs. Puglisi and Williamson for putting together a great series on the Biophysics of RNA. I went to 2 different sessions (both were outstanding), and the remaining sessions were always high on the list of the 5 concurrent sessions I wanted to go to. On Tuesday afternoon, I caught Dan Herschlag's talk, who "wants to set forth principles and physical organic parameters to make RNA folding less mysterious." And indeed, his talk was a great tour through different forces and conditions that need to be considered in elucidating RNA folding. He was also very gracious when I went up after the talk and asked, basically, "can you explain your whole field to me during the coffee break?" In fact, he and the other speakers I cornered got me pretty interested in the topic, so if I ever leave my current job you may find me back at the bench in an RNA lab.

Aside from just being nice people in general, the RNA crowd made a nice counterpoint to the person who found my phone and promptly downloaded nearly $300 worth of games (and as you can imagine, it wasn't in an attempt to spruce it up for me before giving it back...). I guess I'm learning to appreciate all those silly contraptions people have for keeping their phone nearby, as my track record with phones and the ACS isn't so great...

Well, here's hoping the next ACS organizers keep up the good work, or at least that I stop losing things...

Catherine (associate editor, Nature Chemical Biology)

March 29, 2007

ACS: It's over

So the ACS conference is no more. Actually, it feels like it's been winding down since Tuesday, what with all the big banners saying "See you at the next meeting", the posters advertising taxi services to the airport, and people wandering around with their luggage. I think it's a shame that so many people have already gone home by the last day, especially for those who are still presenting. They may not be the biggest names, but it doesn't seem fair that their potential audience is reduced before they even start.

As I mentioned before, this was my first ACS, and I think it's lived up to expectations. I've enjoyed the chemistry (of course) but also the people watching. It seems that more senior chemists are predisposed towards facial hair (especially splendid moustaches), whereas the younger crowd are rebelling by generally being clean-shaved (although a trendy goatee beard is permitted).

Technology now allows for some mind-blowing multi-media presentations, but also inevitably to a random scattering of pop-up error messages. Still, I've enjoyed some of the visual humour. My favourite was the speaker who, when discussing the various organisms that have had their genomes sequenced, provided an image of each species. There was a picture of fruit-fly, a worm, and a chimpanzee. And right next to the chimp, representing humanity, there was George Bush. Say no more.

Anyway, I'll be flying back home tomorrow (oh joy, another 8 hour flight with nothing to do but watch films about penguins. Why is it always penguins?), and then I'm going to lie down in a darkened room for a week. Really.

Andy

Andrew Mitchinson (Associate Editor, Nature)

ACS: Cold fusion anyone?

Things are winding down here. I just went along to the session on cold fusion (read the story here), but my expert timing meant that I arrived just in time for the break. Nevermind, I was treated to an advance showing of one of the talks yesterday. I have to admit, I was skeptical, but this is pretty cool stuff. As Frank Gordon, one of the cold fusion scientists said to me, "this actually looks like real science" - and he's right.

In spite of all the disdain that the field is treated with, the cold fusion people I met were all very positive cheerful people, all completely convinced by their research and with what look like compelling arguments. Even the programme chair for this session (not a cold fusion scientist) told me that he was impressed by the results being presented. He's keeping an open mind on the matter. That's quite a way for the field to come since it was laughed almost out of existence in 1989. Gordon was keen to tell me that since they have been quietly plugging away at their work they have not come under attack in the same way Pons and Fleischmann did. "The silence has been deafening" he said.

Cold fusion? I don't know, but the evidence that something weird is happening is there. Maybe it's time to think about this again...

March 28, 2007

ACS: What happened today?

Hello y'all. Apologies for the lack of posts today, I've been immersed in the world of cold fusion - more of which tomorrow. As such I haven't been to any sessions, which is disappointing, and the conference is almost over - it's certainly winding down. Apparently the ACS bigwigs are already back at home. But the conference still has one day to run. It's going to be quite eerie in the cavernous conference venue if the exodus continues at present rates. More tomorrow....

ACS: Crowded house

Tuesday in Chicago didn't get off to a great start...

I thought I would start my day off with a trip down memory lane and head to the symposium - "30 Years of Conducting Polymers" - the first session of which began with a memorial of Alan MacDiarmid, who passed away in February (the obituary published in Nature can be found here - subscription required).

Well, it turns out that memory lane was a little congested - I turned up at 9:15 to hear the first talk and couldn't even get into the room, people were standing in the corridor watching the talk through the doors! (Note to ACS conference organizers: a memorial session for a recently deceased and well-liked Nobel Laureate, especially one that features a co-recipient of the aforementioned Nobel Prize, should not be held in a room only slightly larger than one of the bathrooms onboard a Boeing 777 jet... - more on this later...)

Deterred, I went a little further down the polymer path and ended up in a talk given by Al Nelson, a former UCLA colleague of mine, and now researcher at IBM Almaden. Al was talking about polymeric self-assembly and molecular recognition, and he gets props for the best 'Moore's Law' kind of slide I've seen in a while... he based it on gaming systems, showing how their capabilities have progressed at a phenomenal rate - from marbles, through to Wii, PlayStation 3 and Xbox 360.

Stuart


Stuart Cantrill (Associate Editor, Nature Nanotechnology)

ACS: Caught in a trap

Having bravely explored the wilds of inorganic chemistry, I decided to meander back to the more familiar territory of organic synthesis, by way of some organometallic chemistry. Braving the overly effective air-conditioning, I shivered through a terrific session in honour of David Milstein. I enjoyed listening to Ilan Marek, who gave a beautifully clear account of some pretty hardcore asymmetric organic synthesis, involving lots of zinc, copper and lithium species. Milstein himself gave a historical overview of his work, including his cool stuff on carbon-carbon bond activation.

But my favourite speaker was Bob Bergman, who wowed the crowd with his latest research on reactions mediated by nanovessels (or cavitands). I love this work - Nature covered some of it in a News & Views article by Julius Rebek last year. Bergman described unpublished results showing that uncharged organic bases (tertiary amines) are actually trapped by cavitands as protonated ammonium cations. This means that acid-catalysed reactions can be perfomed in basic solution! Very nice indeed. Don't forget that we have a News & Views feature article on C-H activation by Bergman in the March 22nd issue of Nature.

It was, all in all, a brilliant day, which ended with that traditional conference activity, a long night in the bar. As a result I'm now feeling a bit like a run-down battery, but that's also traditional after a few days. Time to stoke myself up with coffee, I think...

Andy

Andrew Mitchinson (Associate Editor, Nature).

March 27, 2007

ACS: Hero worship

There was a chance for us to "meet George Whitesides" today. It was a great idea - like a book signing by some celebrity chef or something. Having never met the great man myself I pottered over to the exhibition room and was amused by the long line of people queuing to get their special issue of Chemical and Engineering News signed.

(For those of you who don't know who Whitesides is - he's a professor at Harvard who has the widest ranging research areas I know of - and is doing some interesting work in the chemistry of the origins of life. He's a hero to many young chemists)

I decided not to join the queue, as it didn't seem like I was going to get a chance to really meet the man himself other than to say "Hello, I'm Katharine, from Nature". Still, I hope everyone else was happy. Whitesides himself seemed to be enjoying himself. I even saw one fan who'd had his shirt signed. Has chemistry just gone rock and roll? Yeehah.

ACS: Take a walk on the wild side

My background is in organic chemistry, but the great thing about a meeting like this is that I can learn new things. So yesterday, I decided to explore the strange (to me) world of inorganic chemistry. Frankly, I had no idea what I would discover. I half expected the inorganic attendees to fall silent when I walked into the room, staring at me with hostile eyes, before announcing "We don't like organic chemists in these parts". I think the jetlag is making me paranoid.

But no, it was all cool and I saw some great stuff. Naively, I would never have expected to see an enzyme crystal structure outside of a drug discovery seminar. But then I discovered bioinorganic chemistry, and there were active sites everywhere. John Lipscomb and Steve Lippard gave some cracking talks about the metal species found in enzymes, such as Rieske dioxygenases and bacterial multicomponent monooxgenases. These proteins can be thought of as the original C-H activation specialists. On a similar vein, Thomas Rauchfuss is doing some amazing chemistry to model the active site of hydrogenases.

What I really liked about these sessions was that the lecture rooms were smaller (it was standing room only for Lippard's talk), and the debate was lively. Every talk inspired interesting discussion, and I was impressed by the spirit of academic engagement, which I hadn't really encountered elsewhere. So, if you're sticking closely to your own areas, why not go foraging in foreign territory? You might like what you find.

Andy

Andrew Mitchinson (Associate Editor, Nature)

ACS: Chemists, chemists everywhere and not a drop to drink

Hello again - just to remind you that I am posting more over at the Nature Newsblog - do take a look...

The Sci Mix poster session last night was hot, sweaty, and yet again underground with no natural light. I think I'm going to turn into a mole. And what's this? Free beer at the poster session? Hooray. But there was a catch - you needed tokens, and my humble press registration didn't include any. Thankfully the look of horror on my face when I realised this prompted the nice man standing behind me in the queue to donate one of his tokens. Thanks very much.

The session had some interesting posters - here's a brief run down of my faves.... (oh, and watch out for a news story on the news@nature site later on one of them)

"was Boltzmann wrong?" screamed one poster. Well, I couldn't quite remember what Boltzmann had done apart from have a constant named after him, and the details of that were hazy. Wikipedia tells me it's the physical constant that relates temperature to energy. So was he wrong? No, it turns out, he just didn't have to consider nanoscale properties.

Another poster was looking at using titanium dioxide to neutralise astronaut's waste. And I don't mean their used teabags. Yuck. But I suppose they can't all wear nappies all the time.

There was a great poster that detailed how barnacles can be kept off ship's hulls - but I will let you check back later to read a news piece about that...

March 26, 2007

ACS: The wheels on the bus (don't move at all...)


Though Lake Michigan is quite beautiful, it's pretty tough to appreciate the view when you're in the back of a stalled bus in the middle of Lakeshore Drive. Luckily, it only took 15 minutes for a replacement bus to arrive...

Despite this minor setback, I made it to the conference center in time to see most of the symposium in honor of Dave Evans. Evans talked about a few recent total syntheses from his group, including Oasomycin A, which was recently completed (see also these two papers). He's a great speaker who really holds your attention for the whole talk: he only discusses the most interesting reactions/transformations (and not every single step of the synthesis) and he uses some color (but not too much) to draw your attention to key atoms and/or newly formed bonds.

Later on in the afternoon, I made my way over to see Regan Thomson's talk on his recent synthesis of (+)-symbioimine. I really enjoyed his talk - I've known Regan for years and it's always exciting to see people you know publish interesting work... But the chair of the session really didn't bring her 'A' game today - she had trouble pronouncing his name (calling him 'Dr. Thomas' twice), fumbled through the word 'osteoclastogenesis,' and completely mis-pronounced the name of the molecule. OK - I agree that 'osteoclastogenesis' isn't a very common word, but I think it's pretty important to get the names of the people in your session correct. (Maybe I'm just overly sensitive about names, as so many people have trouble pronouncing mine...)

Well I'm bushed and it's not even 10 PM - it's amazing how exhausted you can get by running around from session to session... For those of you who are here in Chicago, how's your meeting going? What session/talk/event has been the most enjoyable for you? What are you looking forward to seeing tomorrow?

Joshua


Joshua Finkelstein (Senior Editor, Nature)

ACS: milk is dairy, right?

I turned my back on academia a few years ago, but I still like to think I have a modicum of intelligence... So why, in my hotel does the non-dairy creamer have a note on it that says "contains milk"? huh?

ACS: Dean Martin tribute

"When the moon hits your eye like a big pizza pie, That's amore..."
So sang Dean Martin. What's a pizza pie? I often wondered. Now I know - cos I've just had some - it's just a pizza with a massive crust, and miraculously by the power of chemistry that very crust was pumping me full of antioxidants.

Yes, the life of a journalist is a tough one. Here in the ACS press room we are given free pizza. Hooray. But of course, there is no such thing as a free lunch. The pizza was to highlight graduate student Jeffery Moore's research at the University of Maryland. He has tinkered with baking conditions and fermentation processes in dough and shown that longer baking times and higher temperatures lead to more antioxidants forming in the dough.

And that is the very dough they fed us. It might make up for the lack of natural light here in the journalist's cave - surely being outside in the sun and all that vitamin D would be better for us than a pile of greasy pizza - antioxidants or not?

ACS: Listen up kids, it could happen to you

I wouldn't normally go to the health and safety talks, but this one struck a personal chord with me. "Explosion in a refrigerator results in college laboratory fire". Hey, it could happen to anyone. Really, I didn't know that the fridge hadn't been made chemistry-safe. Really, IT COULD HAPPEN TO ANYONE....

... Anyway, on with the story. Lawrence Stephens is professor of natural sciences at Elmira College (apparently the first college to offer degrees to women that were equivalent to men's degrees).

Larry had high hopes for one of his students to crack a particularly tricky chemical synthesis, and was thrilled that said student wanted to do extra work over Thanksgiving. When that student asked if he could leave his solution in the fridge as a final attempt for it to crystalise, Larry said "sure".

It turns out that there was a miscommunication about which fridge was to be used, and the student popped his solution (2 litres of pentane) into a normal fridge in the basic science lab - which also had hydrogen peroxide in it. And the door was firmly closed for 3 days or so. This resulted in a major explosion that gutted the undergrad teaching lab (on a positive note, a brand new and very swanky new lab was built as a replacement).

Now for that personal chime I felt. During my PhD a similar - almost identical thing happened to me. The fridge in my lab - unbeknownst to me - had not been modified so had working electrics inside that cause low flash-point solvents to spark. Oops. My lovely dichloromethane solution never did give me the nice crystals I wanted. But I guess, like Larry, I did get a new lab. (sorry Brian).

As Larry put it, there is a lesson to be learned "we shouldn't have household refrigerators in our labs". Wise words indeed.

ACS: Rage for the machine

Yesterday was a good day for talks, and first up on my talk schedule was the symposium in honour of Ben Feringa, who has been awarded the James Flack Norris Award in Physical Organic Chemistry. Ben wrote the review article on molecular machines that we published in the first issue of Nature Nanotechnology (you can see it here – free access) and it’s always a pleasure to see him talk.

Colin Nuckolls got the session off to a great start with his talk about molecular electronics, where he puts molecules between two carbon nanotube electrodes and then does all sorts of fancy stuff with them... pH switches, metal-ion gating, photoswitching, biosensing... Next up was Takuzo Aida, who wins the award for snazziest (that is a word, right?) PowerPoint so far – treating us to movie after movie describing his light-driven molecular machines.

Dennis Dougherty was next, reminding us that nature has been making molecular machines for a lot longer than we have – and so is an awful lot better at it that us. Josh did a write-up of this talk in an earlier post (see here), but I wanted to comment on the fantastic delivery, especially the dead-pan definition of what a structure-function relationship is... and then pointing out that we would have probably figured it out eventually! Recalling all the debate (in the blogosphere at least) about last year’s chemistry Nobel prize, it was interesting to hear Dougherty say that, “crystallography is physics”.

And then, Ben rounded out the session with his talk about molecular machines and motors. I also caught up with him later at the RSC reception and, with a little arm-twisting, he has agreed to do a ‘Reactions’ piece for the blog (well, he can’t say ‘no’ now, can he?).

Stuart


Stuart Cantrill (Associate Editor, Nature Nanotechnology)

ACS: Lost in space

Chicago. Good for steak, deep-dish pizza and baseball curses (unless you are a White Sox fan). Not so good, however, for ACS meetings.

With the exception of one of the Hyatts, the hotels are a loooooooong way from the convention centre. To be fair, the bus service has been good, and I haven’t had to wait more than a few minutes to get on one. Once you get dropped off, however, the session you are interested in could be a day’s hike away – as for all of you multidisciplinary types out there who fancy some PMSE one minute and some ORGN the next, forget it.

Finding the press room was also a challenge – I was very conscientious, printing out the e-mail that I received before the meeting, telling me exactly where to find it... it’s just a shame that the room number I was given just had a passing resemblance to the actual press room... what’s a couple of digits between friends?

Lunch is another matter. As Ben Davis remarked yesterday as he sped off in the opposite direction in search of a sandwich; 11,000 delegates, 4 restaurants - the maths just doesn’t work. We were a relatively quick moving Starbuck’s queue away from having fudge for lunch... yes, there is a fudge shop in the convention centre, so it’s not all that bad.

Stuart


Stuart Cantrill (Associate Editor, Nature Nanotechnology)

March 25, 2007

ACS: I fought the law...

Hello from Chicago!

I'm one of the editors attending the ACS, and arrived in Chicago last night. Actually, late last night, since my plane (and Josh Finkelstein's - check out his post for more details on our flight crew) was 2 hours late. But, this turned out to be extremely important, because it allowed me to 1) have time to read the entire current issue of Nature and 2) see some additional experiments that are going on right here in Chicago firsthand. What am I talking about, you may ask? Let me explain (and let me also offer the disclaimer that I last took physics in 1997, so be nice):

One of the news items in this issue of Nature discusses Newton's second law. In this piece, we learn that Alexander Ignatiev is trying to prove the existence of modified newtonian dynamics by observing whether a small piece of the world (literally, two spots at the north and south poles a few centimeters across) moves in the absence of external force. This is quite difficult because normally everything on the earth is moving due to the movement of the planet. While there are a multitude of challenges to overcome, it seems that Ignatiev is excited about the prospect.

So excited, perhaps, that it seems local Chicago folk have picked up on his enthusiasm. In particular, last night I was looking for some dinner and found a place that would give me a burger to go. After I finally got the enormously oversized bag, I was ready to head back to the hotel through the restaurant's revolving door. Unfortunately, as I stepped into the space, apparently someone else on the other side was one moment ahead of me, and started pushing on the door before I could get all the way in. Once she saw me (and noticed that my hand, holding the burger bag, was close to being forever separated from the rest of me), she stopped her forward motion briefly, allowing me to think that I could at least get my hand and said bag out of the door before both were pulverized. Then, while I was still obviously fumbling to get the elephantine bag out of the door, she apparently noticed a unique opportunity to test Newton's first law, which states:

An object at rest will remain at rest unless acted upon by an external and unbalanced force. An object in motion will remain in motion unless acted upon by an external and unbalanced force.

Upon this realization that she could actually be the first to demonstrate modified newtonian dynamics, she started pushing on her part of the revolving door again, no doubt expecting that the object at rest (the door on my side) would somehow stay at rest, even given the external and very unbalanced force being applied to it.

Alas, Newton wins again. And I ended up with burger salad.

But thanks, Chicago, for inviting me to take part in your scientific pursuits. I look forward to more scintillating experiments during the rest of the conference.

Catherine (associate editor, Nature Chemical Biology)

ACS: Like a virgin

I have a confession to make - this is my first time. Even though I've been to conferences all over the world, somehow I've never made it to a national ACS meeting, until now. For the benefit of newbies everywhere, here are my first impressions.

This is certainly the largest conference that I've ever tackled, and the choice can be confusing. My pre-planning involved checking out the schedule online, but I didn't cope very well with the ACS search engine, so I eventually just decided to wait until I had the printed version to browse through. Even then, it was difficult to know where to start. With hindsight, perhaps if I'd arrived in Chicago early enough to register yesterday, that would have give me more time to browse the technical program before things got under way.

Of course, choosing which lectures to attend is only part of it - finding the lecture theatre can be a task in itself. And if you have any plans to hop between sessions to cherry-pick lectures, think carefully - the lecture theatres can be distant from each other, so you might end up missing chunks of the talks.

Some of the lecture theatres are huge, which oddly enough was a problem sometimes. I saw some excellent talks today, with respectable attendances, but when the audience is scattered across a vast room it can seem as if there's only a few people there. It's only when you find yourself joining the throng trying to get lunch that you realize just how many people there are.

A conference this size must be a logistical nightmare to organize, and barring a few niggles (more restaurants perhaps? And a hotel room that actually had its own bed would have been good last night - don't ask) it' s been a great day. I can't wait for tomorrow. How was it for you?

Andy


Andrew Mitchinson (Associate Editor, Nature)

ACS: My kind of town


I made it in to Chicago late last night (only two hours late, which for isn't that bad for O'Hare...) There must have been a few chemists on my flight, as I wasn't the only person who chuckled when they announced that our pilot's name was Dave Evans...

I got up early this morning to check email, plan my day at the conference, and make a few last minute adjustments to an iPod playlist (it's a 20-25 minute bus ride from my hotel to the convention center). When traveling for work, I usually create a playlist to 'match' the location of the conference: Radiohead works well if you're heading off to an RSC conference, but a meeting in Chicago really calls for some Robert Johnson and Muddy Waters... (This isn't always easy - I'm not sure what I'm going to do for the 2009 ACS meeting in Salt Lake City. Any suggestions?)


Anyways, this morning I saw a great talk from Dennis Dougherty - most of the talk focused on cation-pi interactions in ligand-gated ion channels (for example, the Cys-loop superfamily) and how his laboratory has used unnatural amino acid mutagenesis to dissect how nicotinic acetylcholine receptors work (click here for his Nature paper from 2005 - I think it's a great demonstration of how organic/physical organic chemistry can be used to reveal how a biological system works...)

After grabbing a quick (and remarkably expensive) bite to eat, I went to Linda Hsieh-Wilson's and Jotham Coe's talks, both of which were great. Coe talked about Varenicline/Chantix, which looks like it'll really be able to help people who want to quit smoking.


If you're blogging from the conference, please let us know/please feel free to mention it in the comments section - so far, I know that

Richard from Chemistry World
Egon from chem-bla-ics
Kyle from The Chem Blog

are here (I'm not sure if all of them are blogging, though...) As Katharine mentioned, her news@nature blog posts can be found here.

Joshua


Joshua Finkelstein (Senior Editor, Nature)

ACS 2007 - Nature newsblog

Hi from the ACS. I'm reporting for news@nature while I'm here, and you can read it all here.

March 23, 2007

NPG at the 2007 Spring ACS meeting


As you probably guessed, several editors will be attending the spring ACS meeting next week - you might remember that we created special conference websites for the spring and fall ACS meetings last year. This year there's been a major overhaul to our Chemistry Portal - in addition to the list of recent content from Nature, Nature Biotechnology, Nature Chemical Biology, Nature Materials, Nature Methods, Nature Nanotechnology, Nature Protocols, Nature Reviews Drug Discovery, and news@nature.com, there's a new section entitled "Looking Back."

The "Looking Back" page contains a list of Nature chemistry papers that 'caught our eye' for one reason or another and were published between 1950 and 2000 - there are a few 'classic' Nature papers (for example, Watson & Crick's Molecular structure of nucleic acids: a structure for deoxyribose nucleic acid and Kroto et al.'s C60: Buckminsterfullerene) and a few you might recognize from courses you took in college or graduate school (for example, Jones et al.'s paper Stereochemistry of phosphoryl group transfer using a chiral [16O, 17O, 18O] stereochemical course of alkaline phosphatase and Nicolaou et al.'s Total synthesis of taxol). There's even a 1950 paper from RB Woodward (Structure of chlorodesoxypatulinic acid) and a 1969 paper from EJ Corey (Biological activity of synthetic prostaglandins)... Have a favorite? Think we missed a key paper? Please let us know...


As Katharine mentioned yesterday, we've also put together a special issue of Nature - the issue is packed full of chemistry, so if you're at the meeting, swing by the NPG booth and pick up a free copy...

There's a News & Views Q&A on C-H activation from Bob Bergman, a review article from David Gorin & Dean Toste on relativistic effects in homogeneous gold catalysis, a Careers and Recruitment piece in our Naturejobs section, and several primary research papers:

Total synthesis of marine natural products without using protecting groups by Phil Baran et al. (click here to read the N&V)
Biasing reaction pathways with mechanical force by Charles Hickenboth et al. (click here to read the N&V)
BluB cannibalizes flavin to form the lower ligand of vitamin B12 from Michiko Taga et al. (click here to read the N&V)

We'll be adding blog entries throughout the conference, so please check back frequently to see what we’re writing about...

See you at the meeting!

Joshua


Joshua Finkelstein (Senior Editor, Nature)

Reactions - Fraser Stoddart

1. What made you want to be a chemist?

The opportunity to be a creative designer and an engineer of form and function at one of the smallest and most challenging of material levels - namely, the molecular one, in the beginning with all its fancy regulations involving valency and bonding and the like. Quite early on, my imagination started to run riot far beyond the molecule where the fundamental challenges in chemistry lie hidden today in the much more subtle rules that govern weak noncovalent bonding interactions.

At the outset, I would never have dreamt that I would be chasing complexity and emergent phenomena under the guise of chemistry but that's what is happening now. My experience has been a highly evolutionary and incremental one. I started with a hunch and a hope. I did not really know where chemistry would lead me, other than into the uncharted and the unexpected. I followed my nose but it was most certainly not smells or, for that matter, bangs that got me hooked on chemistry!

2. If you weren't a chemist and could do any other job, what would it be - and why?

I would very much like to have been a highly successful writer and novelist. I have always had a fascination with the words and phrases that make up the English language. In fact, writing far too many scientific papers has given me the opportunity to develop my skills - which were dreadfully bad when I was in my twenties - during these past 40 years. If I am spared long enough, then I would love to put pen to paper in ways that might help to bring the excitement of being a scientist, totally and utterly addicted to chemistry, to a wide lay audience in many different places around the globe. We all have a right to dream a little!

3. How can chemists best contribute to the world at large?

By being an integral part of it, not only in a materials sense, but as folks who care so deeply about our planet that we would be ready, willing and able to provide it with an alternative way forward into the future that values and honors the sanctity of all living things, including human beings, on the planet. Much of our world revolves around chemistry, probably more than around any other creative medium.

In the 19th century, chemists gave the world dyes and made our lives more colourful, in the 20th century, chemists gave the world drugs (pharmaceuticals), so lengthening our lives and making them more bearable, and, in the 21st century, chemists will give the world devices, making our lives much more fulfilled and immensely more enjoyable. These three d's are made possible by chemistry which is, in turn, about three m's – making, measuring, and modeling – and a lot more which could make our world a better place for better living for all of us.

4. Which historical figure would you most like to have dinner with – and why?

William Shakespeare. He was so brilliant and so highly prolific in an out-of-the-box kind of way during such a short and precarious period in history which coincided with the expansionary phase of the Elizabethan Age. I would like to learn from him how he organized his time in order to meet deadline after deadline. He must have had an extremely vivid imagination to have invented all those rich phrases he introduced into the English language.

I would like to have him tell me that he did it all by himself (for I suspect he did) so that I could hold him up as a role model to all the young people in my life whom I urge to do 200 times more than they do currently in their own lives. As one who gets endless fascination out of watching and analyzing human behaviour, it would also be such a privilege to listen to one of the all-time experts on this subject. I suspect I might come to know myself a lot better after dinner with the Bard.

5. When was the last time you did an experiment in the lab - and what was it?

Twenty-nine years ago in the summer of 1978 when I left the University of Sheffield to go to the ICI Corporate Laboratory in Runcorn on a three-year secondment. During the 70s, I ran all the NMR spectra for my medium-sized research group since postdoctoral fellows and (post)graduate students were not allowed to use the NMR spectrometers in the Sheffield Chemistry Department, then. I gained access, free from all competition, at five in the morning when my two young daughters made darn sure that I was on my way to the NMR lab at that unearthly hour. By the time we returned as a family to Sheffield in 1982, my daughters had both learned how to sleep and the NMR spectrometers had also become far too sophisticated for a simple-minded guy like me to be able to use them.

6. If exiled on a desert island, what one book and one CD would you take with you?

A well-illustrated (in colour!) and user-friendly English dictionary so that I could extend my rather limited vocabulary, while listening to the Beatles (particularly Paul McCartney singing “When I'm Sixty Four” for that's what I am!) on that one and only CD. After the tradition of that long-running BBC Radio 4 programme, Desert Island Discs, I am assuming that the complete works of Shakespeare will be already there on the island.

If, in the spirit of the programme, which incidentally was first broadcast in the year I was born, I can also choose one luxury item, then it would be an endless supply of Liquorice Allsorts. Guess what, if I told you I have only three ambitions left in life, what one of them is? Right! To be invited to be a guest on Desert Island Discs.

Sir Fraser Stoddart is in the Department of Chemistry and Biochemistry at the University of California, Los Angeles and works on the use of molecular recognition and self-assembly processes in template-directed protocols for the syntheses of two-state mechanically interlocked compounds (bistable catenanes and rotaxanes) that have been employed successfully as switches in molecular electronic devices (MEDs) and as artificial motor-molecules in nanoelectromechanical systems (NEMS).

March 22, 2007

Mechanical chemistry

This week's Nature is stuffed full of chemistry. My favourite is a paper by Jeff Moore about mechanically pulling apart chemical bonds.

A news story about the paper can be found here

There are also some videos to go with the story.

Oh, and I am going to be reporting from the ACS meeting in Chicago, so hope to see you there...

March 20, 2007

Comin' atcha, NChB style

Hello chemists of the world!

In honor of spring (well, one day early), our April issue is alive and blooming. Unfortunately, the bloom in question is a fungus, so that's not something you want to put in a vase, but it still looks pretty nice!

We're pretty excited about our issue this month because this marks the first issue where you'll be able to see in 3D! That's right - the chemical compounds that accompany each paper can now be viewed as balls and sticks, zoomed in or out, and rotated around thanks to jmol. It's like going back to organic class, but without the work (and without always running out of carbon atoms just before you finished).

In honor of this occasion, those of you who'll be at the ACS next week can stop by the NPG booth and get a 3D poster and glasses (I'm planning on wearing my 3D glasses throughout the meeting - it's all the rage, you know). And for those of you who aren't going, but want a 3D poster, let me know and I'll send you one (at least until we run out, and then maybe after that too).

See you in Chicago!
Catherine (associate editor, Nature Chemical Biology)

March 19, 2007

Making a list...


We’ve decided to create a chemistry eTOC (an "electronic Table of Contents") that will highlight recently published chemical & biochemical papers from Nature, Nature Chemical Biology, Nature Materials, Nature Reviews Drug Discovery, Nature Nanotechnology, Nature Biotechnology, Nature Methods, and Nature Protocols.

For now, the chemistry eTOC will include ‘back half’ content (primary research and review articles) from all eight journals and ‘front half’ content (editorials, news features, news & views, etc.) from Nature. (Our long-term goal is to include ‘front half’ content from the research journals as well…) In addition, the eTOC will contain recent blog posts from this blog, highlight several chemistry jobs from our NatureJobs website, let you know about other developments from NPG in chemistry, and will occasionally include content from other NPG titles (for example, the recent Nature Reviews Microbiology review entitled "Microfabrication meets microbiology" and the 2006 Nature Reviews Molecular Cell Biology review entitled "A chemical toolkit for proteins – an expanded genetic code").

We’re hoping that this eTOC will make it easier for chemists who only read one or two NPG journals find interesting papers/reviews/etc. that are published in other NPG journals (for example, ones that they rarely/never read from cover-to-cover).

The first eTOC will go out during next week's ACS meeting (on Monday, March 26th) and future eTOCs will be sent out twice a month - so please sign up today!

Joshua Finkelstein (Senior Editor, Nature)
Stuart Cantrill (Associate Editor, Nature Nanotechnology)

March 16, 2007

Reactions - AP de Silva

1. What made you want to be a chemist?

Coming into contact with a brilliant chemistry teacher at pre-university class in school. Errol Fernando inspired not only me but generations of Sri Lankans, and later Pakistanis, who went on to various professions around the world. However, I am also delighted that chemistry is a subject rooted in the world from ancient times, i.e., reality would be closely connected with what chemists do. We can let our thoughts soar as high as we like, but at the end of the day, what we do with matter in all its forms has possibilities for good and bad, which also needs to be dwelt upon.

2. If you weren't a chemist and could do any other job, what would it be - and why?

A percussionist/drummer. I’ve enjoyed playing informally since childhood, probably because Sri Lanka has an excellent drum tradition going all the way from high classical to a knockabout with friends. Hitting things to get a sound out of them (no violence) is brilliant fun. Drumming has a great, rather primeval, way of connecting with people like nothing else I know. My dream was to play weekends while doing chemistry as the day job. Luckily, I’ve been doing something pretty close to that for the past decade.

3. How can chemists best contribute to the world at large?

As mentioned under 1, our work as chemists directly impacts on the world at large, albeit in the hands of managers and corporations. In fact, the ‘white-hot revolution’ of yesteryear and the ‘knowledge-based economy’ of the present have a clear chemistry foundation in terms of new materials and processes. That is a positive contribution, at least at the point that chemists have control. However, we must also contribute positively by developing the tools for monitoring the final outcomes in an environmental/medical sense. Additionally, we must contribute by talking with the media in a transparent and understandable manner since they determine what the world sees and hears.

4. Which historical figure would you most like to have dinner with – and why?

The first woman prime minister in the world - Sirimavo Bandaranaike. The stunning originality of her accomplishment was perhaps not appreciated globally as it should have been. It was one of those instances where a small country showed the world the way. Also, she presided over Sri Lanka at a time which proved to set the course of the country up to the present time and beyond, with all the attendant sadness and broken dreams. There would be so much to ask her.

5. When was the last time you did an experiment in the lab - and what was it?

Two years ago, a friend and I tried to coax a fluorescence emission spectrum from a single polymer bead tagged with a molecular computational identification (MCID) tag with a common spectrometer in the room where I work to this day. This effort failed, but we were happy because we could get a result with 3 beads. A bit more tweaking or a slightly more specialized spectrometer, and we would be home and dry. Other experiments established MCID as a viable tagging technology for micrometric or smaller objects in large populations - a bit of molecular computing that could do widely useful things that silicon-based computers couldn’t do.

6. If exiled on a desert island, what one book and one CD would you take with you?

Nihal Fernando’s ‘Sri Lanka-A Personal Odyssey’ (ISBN 9559236032) is a bittersweet photo-essay about this beautiful, but troubled, land. It reminds me of a wonderful past which hung on till not so long ago. Kevin Burke’s ‘If the cap fits’ is Irish fiddle playing at its raw and beautiful best. This music in all its forms has been a large part of my attraction for Northern Ireland. The format of the Irish music session, with its circle in a bar where punters and players are equal, appeals greatly. That feeling of elation/exhaustion at the end of a long non-stop session is also worth a lot.

AP de Silva is in the School of Chemistry and Chemical Engineering at Queen's University Belfast and works on molecular sensing, logic and computing.

March 09, 2007

In the bag?

A little while ago I read that the French firm J&M Plast, part of the European packaging group Sphere, was turning to potato starch to make a new biodegradable plastic material for bin bags (unsurprisingly called ‘Bioplast’). L’Usine Nouvelle reports on it here - the link is in French but you’ll find an English version on Matthieu Fossoux’s blog. Biodegradable polymers are now widely investigated – starch-based polymers, polylactic acids (PLA) and polyhydroxyalkanoates (PHA), naturally produced by bacteria, being among the most promising.

Meanwhile, retailers are increasingly switching to a “pay per bag” policy. This has proved to be very effective in the past, with a reduction by 90% in plastic bag consumption in the Republic of Ireland, where customers have been charged per bag since 2002. The Swedish furniture manufacturer Ikea has also adopted a similar policy in the UK, and is reporting a massive 95% drop since last June. Ikea is now extending this scheme to the US and all the profits (with a limit of $1,750,000 within 12 months) are to be donated to the non-profit organization American Forests to plant trees and offset carbon dioxide emissions.

While too many shops still routinely give out plastic bags, these reports are certainly encouraging – and the great news is: we can all contribute.

Anne


Anne Pichon (Intern, Nature Reviews Drug Discovery)

Reactions - James Tour

1. What made you want to be a chemist?

I loved organic chemistry - best class in all of college.

2. If you weren't a chemist and could do any other job, what would it be - and why?

Surgeon; I like to help people and enjoy detailed work.

3. How can chemists best contribute to the world at large?

Become civic scientists, aiding on boards and panels that interest them and society.

4. Which historical figure would you most like to have dinner with – and why?

Jesus Christ because he is God having appeared in the flesh, and he is the one that I love more than life itself.

5. When was the last time you did an experiment in the lab - and what was it?

As I recall, it was a methyleneation of carbonyl compounds in 1989 for my first publication as an assistant professor.

6. If exiled on a desert island, what one book and one CD would you take with you?

The Bible and the CD of all Charles Spurgeon’s (19th Century Minister) recorded sermons and books.

James Tour is the Chao Professor of Chemistry, Professor of Computer Science, Professor of Mechanical Engineering and Materials Science and the Director of the Carbon Nanotechnology Laboratory at Rice University and works in the area of molecular electronics, nanotubes and nanocars.

March 08, 2007

Don't know much about chemistry...

I’m going to be moving house in a few days time, and the packing process is in full swing. Yesterday, as I was emptying my cupboards, I found some old notes for a talk that I gave at a local school. It was aimed at ten-year-olds, and was intended to fire them up about chemistry.

As I recall, the talk went quite well. I finished off with a few ‘kitchen chemistry’ experiments — indicators made from boiled red cabbage, acid-base reactions with vinegar and sodium bicarbonate, anything that was safe, colourful and went ‘pop’. The teachers asked the kids to write about what they’d seen, and showed me some of the reports about a week later.

I was shocked to see that almost every single report began with the words “When I found out it was a talk about science, I thought it was going to be really boring.” Fortunately, they always went on to say they actually really enjoyed it, and I was pleased to see how much they’d taken in.

Talking with the teachers, they said they weren’t surprised at the children’s initial response, as they often didn't have time to teach some of the more fun aspects of science. This struck me as quite worrying, given recent concerns in the UK that science has fallen out of favour with university students.

So is chemistry education, especially for younger students, too restrictive? Is the situation different in other countries? And did any of you get hooked on chemistry because of an inspirational teacher?

Andy


Andrew Mitchinson (Associate Editor, Nature)

March 02, 2007

Back from hiatus...

Hello, fellow readers and bloggers. I'm back from a blogging break and just wanted to share some exciting chemistry-related papers from the March issue of Nature Methods.

From Ruedi Aebersold and colleagues, we have a paper that