1. What made you want to be a chemist?

Organic chemistry, ironically enough. I was studying biology and had taken general chemistry, which I did not find terribly exciting. It was organic chemistry that really put the idea forward that chemists can make molecules, and the idea of making molecules, particularly ones never seen before, has been driving me ever since.

2. If you weren’t a chemist and could do any other job, what would it be - and why?

If I were not a chemist, something else I'd like to be. If I were not a chemist, a window cleaner, me! With a rub-a-dub-dub…In all seriousness, that is a tough call. It's funny because my job is a professor, but when I meet people and they ask what I do, I instinctively answer chemist, so it'd be hard to that up give up. I think I'd have to go to culinary school and become a chef. That seems like another profession that combines creativity and the making of new things. As a plus, it would be easier to explain to people what I do.

3. How can chemists best contribute to the world at large?

Chemistry has already made tremendous contributions, but it is no time for the science to rest on its laurels. Currently, energy is an area where chemistry can make a major contribution — one that is desperately needed. From more efficient processes and green syntheses to new technologies for better harnessing the sun's energy to carbon dioxide remediation, these are all chemical problems. That's not to say that chemistry would not make a large impact on many other areas, but energy crises are and will be sufficiently pressing to demand precedence. Ultimately, most of these energy problems are fundamentally about making and breaking chemical bonds or building new molecules.

4. Which historical figure would you most like to have dinner with - and why?

I'm not a big fan of this going to dinner with historical figures. It seems like a formula for disappointment. However, it would be fun to talk coordination chemistry with Alfred Werner. More than that, it would be wild to share with him some of what we have learned since that time and get his reaction.

5. When was the last time you did an experiment in the lab - and what was it?

This morning, I finished brominating an arene and then I protected an amine to build some new ligands, but that is all known chemistry. Not too long ago, I made a new nickel complex that we're hoping will be a good bond-forming catalyst. It turns out that I can make the nickel complexes, but I don't know about the catalysis yet.

6. If exiled on a desert island, what one book and one CD would you take with you?

The CD would be an easy choice — Duran Duran's Greatest. The book is a little more difficult. Given the amount of time "exiled" implies, I'd go with Thus Spoke Zarathustra by Nietzsche. It'd be a good foil for the Duran Duran. I wonder what I did to get exiled...maybe reading James Marshall’s George and Martha: The Complete Stories of Two Best Friends will help me be readmitted to society….

Rory Waterman is in the Department of Chemistry at the University of Vermont, where he uses organometallic chemistry to address problems in synthesis, materials, and energy.

Posted by Neil Withers at 06:39 AM | Permalink | Comments (0) | TrackBacks (0)

Posted on behalf of Sugar Daddy, with a nod to Andy's recent post

As a fifth-year chemical biology graduate student, I sometimes wonder if I'll know when I've been in grad school too long. Maybe I'll want to finish that last project, or start something anew to pass along to a new student. Maybe a personal life decision is playing a factor in my wanting to leave now or stay longer. Maybe I look around at group meeting and realize that free pizza once per week isn't as great as it used to be, partially because I know what everyone in the group is working on and am slightly less interested in it than I used to be. Maybe I read every paper in my field with such a critical eye that it all seems boring now when it was so exciting only a few years ago.

But sometimes you need something more direct, like a kick in the face, a surefire sign that it's time to pack up the pipets, file away the round bottom flasks, and start looking for greener pastures in some other field of science. Last week, I think I got that sign: VWR and Fisher simultaneously told me that the world is out of acetonitrile. Yup, that's right. If I ever need a sign to graduate, it's that the world has run out of one of the two solvents that I use on the HPLC. (Given that the other solvent is water, I guess if I had to pick which one I'd rather run dry... I guess the situation could be worse.)

The story there is somewhat interesting. I'll write what I've heard, and please write any comments if what I'm saying is rubbish or not. Basically, the most economically viable way -- and currently the only way -- that acetonitrile is produced is as by-product of acrylonitrile production. Acrylonitrile is a monomer that finds its way into nylon, acrylic, plastics, and all sorts of products; it is a much more important product in the global marketplace than pitiful little acetonitrile, the by-product of acrylonitrile production.

So, acetonitrile supplies are tied to the laws of supply and demand in the acrylonitrile market. Given the global economic situation, building construction projects and the general production of goods -- that is, things that rely on products made ultimately from acrylonitrile -- are all way down. Therefore, demand for acrylonitrile is down; the price of acrylonitrile has plummeted in the last few months, and production is drying up. Unfortunately for us chemists, the demand for acetonitrile, the bastard step-child of acrylonitrile production, has remained relatively constant, because HPLCs still need to run even if Lehman Brothers has closed up shop and GM isn't far behind.

Wikipedia claims that the situation was caused by a shutdown of acrylonitrile production in China last summer because of the Olympics and damage to a plant in Galveston, Texas due to Hurricane Ike, but as I understand it, these are medium-sized blips that are only exacerbating a larger market situation.

Acetonitrile shortages have happened before and will happen again. Like the famously flamboyant former Canadian prime minister, Pierre Trudeau, once said about Canada's proximity to and geopolitical entanglement with the United States, "Living next to you is in some ways like sleeping with an elephant. No matter how friendly and even-tempered is the beast, if I can call it that, one is affected by every twitch and grunt."

So, basically, we're not in a very good place until someone can figure out how to make acetonitrile independent of acrylonitrile production in a way that is economically viable. Then we can finally kick the elephant out of our bed, allow the acetonitrile market to be regulated by its very own market forces, and maybe keep me from interviewing for postdocs and writing up my thesis.

Hmm... perhaps a good puzzle for a lazy Thanksgiving afternoon? Thanks for the idea, SD! Catherine

Posted by Catherine Goodman at 03:43 PM | Permalink | Comments (0) | TrackBacks (0)

Let's be havin' some Research Highlights.

Ring-closing metathesis lets you (well, organic chemists) make a lot of different sizes of rings, and is tolerant to different functional groups, but it still can't quite do everything. It's domination of the world has come a step closer, however, thanks to some fluxional ligands. The catalysts are stereogenic at the metal centre, meaning you (well, organic chemists) can do rapid enantioselective catalysis.

Papers about hydrophobic surfaces often contain great pictures and/or videos of the materials in action (which provides me with another excuse to link to the superhydrophobic desktop hockey video!), but materials that can repel organic species are much rarer. So creating a surface that is repellant to both "oil" and water is pretty impressive. It's all about the shape of the surface features...

As people's responses to Question 3 in Reactions interviews are telling us, it's All About Energy. So understanding how enzymes work - for example oxidising hydrogen - could give us clues on how to produce energy more cleanly. Which is why studying how a model of hydrogen bonding to a di-iron model of an enzyme can reveal the role of electron-donating ligands on the spectator iron.

Did you enter the Dance your PhD thesis competition?? I hope so - you can enjoy the winning entries here.

Neil

Neil Withers (Associate Editor, Nature Chemistry)

Posted by Neil Withers at 05:15 AM | Permalink | Comments (0) | TrackBacks (0)

1. What made you want to be a chemist?

When I was a kid, I wasn't particularly good at baseball or any other sports, so I would hang out in my basement with a chemistry set and play with it. I had a truly outstanding chemistry teacher in high school (Frank Cardulla, who received the 2000 American Chemical Society Conant Award for High School Chemistry Teaching) and in college I had the privilege of taking courses from and doing research with Dudley Herschbach, the 1986 Nobel Laureate in Chemistry.

2. If you weren't a chemist and could do any other job, what would it be - and why?

I thought seriously about going into medicine, but decided I did not have the appropriate bedside manner. I think most of my friends and colleagues would agree with me.

3. How can chemists best contribute to the world at large?

Many of the world's major problems such as climate change and the need for renewable energy sources will be solved by chemists. These problems require a fundamental understanding of matter at the molecular level. Chemists have this.

4. Which historical figure would you most like to have dinner with and why?

I find Josef Stalin to be the one of the most fascinating historical figures over the last 100 years, but I'm not sure I would want to have dinner with him. Then again, an evening of borscht and vodka might not be so bad.

5. When was the last time you did an experiment in the lab - and what was it?

I was pretty involved in experiments on transition state spectroscopy in my research group when I started at Berkeley in 1986. Once I got multiple projects going and realized the students could run the instruments better than I could, I began distancing myself more from the day-to-day operations. But I still visit my labs on a daily basis and (much to the horror of my students) will turn knobs on occasion.

6. If exiled on a desert island, what one book and one CD would you take with you?

War and Peace. I've always wanted to read it but never had the time. And Beethoven's 9th on CD.

Daniel Neumark is in the Department of Chemistry at the University of California, Berkeley, and works on chemical dynamics, spectroscopy, and cluster science, with particular emphasis on using negative ion photodetachment to probe transition states and other transient species.

Posted by Neil Withers at 06:47 AM | Permalink | Comments (0) | TrackBacks (0)

It seems like we've had endless headlines screaming about the collapsing world economy. Scary times for everyone. If you're one of the many chemists who has been made redundant recently in the 'restructuring' of big pharma (or indeed if you've been made redundant from any sector), hang on in there. I know exactly what it's like - I won't offer any trite homilies, especially when the job market looks so bleak, but I wish you luck for the future.

On a less personal note, it seems that the credit crunch is affecting research in other, less obvious ways. I was talking to a friend recently, and he commented that his company is having difficulty finding reliable supplies of acetonitrile. He told me that, apparently, one of the biggest uses of acetonitrile is for making certain car parts. But in the current economic climate, no one is buying cars, and so the demand for car parts has evaporated. You might think this would create a glut of acetonitrile - but acetonitrile manufacturers have realized that the bottom has dropped out of their market, so they've stopped making it. I don't think the world is about to run out of this solvent, but it's another example of how nothing seems certain anymore.

Have any of you experienced other unexpected side-effects from the economic crisis?

Andy

Andrew Mitchinson (Senior Editor, Nature)

Posted by amitchinson at 05:13 AM | Permalink | Comments (5) | TrackBacks (0)

There’s a huge amount of literature out there, and come April, we hope to be bringing some of the best of it directly to you in one neat little package called Nature Chemistry. Until the journal launches, we have to satisfy our cravings by bringing you a weekly dose of Research Highlights. Every week the Nature Chemistry team gets together to discuss our selections. We like to be as current as possible in terms of the work we select and to achieve this we are big fans of the RSS feed – it seems unlikely that anyone reading a blog would be unaware of this technology but for the uninitiated.

I don’t want this post to turn into a rant, so first let me say how much I like the new JACS homepage, especially the interactive pdfs. While the citation links have been available in HTML format for some time, I think I can safely say that a lot of people just like to read the pdf. However, at the same time, the RSS feeds for the ACS journals no longer include the table of contents images. In an ideal world, a title would tell you everything you need to know, but I do like a nice picture to whet the appetite.

Of course the ACS are not the only ones at fault, and I’d like to see the graphical contents in all journal RSS feeds – Angewandte Chemie also do not include images from their RSS feed and neither does Nature (although they don’t have a graphical TOC), but I guess you don’t miss what you never had!

Recently, we at Nature Chemistry were silently grateful to the creator of a pimped Angewandte RSS feed, so why not join me in my campaign – a plea to the ACS to reinstate the images in their RSS feed, or to our friend at the Organic Chemistry blog to work the magic again – either way it will make my week (it’s also possible that this is a relaunch bug…but just in case).

***Update - it does appear to be just a bug***

Steve

Stephen Davey (Associate Editor, Nature Chemistry)

Posted by Stephen Davey at 04:30 AM | Permalink | Comments (3) | TrackBacks (0)

It's a good week for Research Highlights...

Firstly, it's good to see chemists really getting in on the act with graphene. The original route to make it (using sticky tape) was a little bit comical, but "chemical" methods were hindered by the sheets of carbon atoms re-aggregating. It turns out that using the reducing agent, hydrazine, as a solvent as well stops the problem.

Next, electrodes have been used to investigate biological signalling for oooh ages. But most biological signals are chemical, not electrical. To investigate them, Rustem Ismagilov and colleagues have created a microfluidic 'chemistrode' - it can stimulate, record and analyse the released molecules. [Alternative headline for this piece that I wouldn't let Gav get away with: Chemistrode to joy. Groan.]

Thirdly, sulfur can form bonds to itself very easily (hence its many allotropes), but it can also form 'hypervalent' bonds (in sulfuranes) - where its formal valence is above 8. Organic compounds like this are incredibly rare, and generally unstable, so its quite an achievement that a sulfur-substituted organosulfurane has been made and structurally characterised. Similar S–S bonds are found in proteins, so the ease with which they can be cleaved in this model has implications for redox processes in biology.

And finally, in an effort to even up the culinary War of the Roses, here is a link to a recipe for Lancashire Hotpot. It's quite interesting to see that the page says "Keep in mind that this is cooking, not chemistry, so a few grams this way or that won't matter." What an excellent and accurate sentiment!

Neil

Neil Withers (Associate Editor, Nature Chemistry)

Posted by Neil Withers at 05:41 AM | Permalink | Comments (0) | TrackBacks (0)

1. What made you want to be a chemist?

As a child I was intrigued with building (my father was in the building trade) so I guess in some respects I took his lead but down to the nanometric dimension. I love the definitive nature of chemistry and the way you can create new things or new processes or provide an understanding of the world around us. I was also lucky to have some great science teachers at school. Mrs. Steenholdt, Mr. Djoneff and Dr. Commons were extremely enthusiastic teachers across the science discipline when I was at high school and really spike my interest. I studied a biochemistry/chemistry major at university and enjoyed the chemistry of biology more than the molecular biological aspects of biochemistry. However, my chemistry teaching is often framed from a biological viewpoint.

2. If you weren’t a chemist and could do any other job, what would it be - and why?

It was a toss-up between chemistry and landscape gardening when I left school. The latter is an extremely creative profession and combines outdoor work with intellectual inventiveness and manual dexterity. There are some similarities to chemistry here!

3. How can chemists best contribute to the world at large?

Chemistry is all pervasive throughout the world within which we live and the society we live in. From medical diagnosis and drug discovery, through the development of novel materials, to addressing the concerns surrounding environmental issues (to name only a few…). Scratch the surface and you’ll find a chemist.

4. Which historical figure would you most like to have dinner with - and why?

Captain James Cook. His voyages of discovery throughout the ‘new world’ were truly amazing, the stuff of legend. His skill as a navigator, explorer and cartographer know no equal. He’d have a few travel stories to tell. If he weren’t available then I could settle for Salvador Dali, Pablo Picasso or Vincent van Gogh.

5. When was the last time you did an experiment in the lab - and what was it?

A true irony of being an academic is that you are able to spend less time in the lab. However, when time permits I do set up a few crystallisations and solvothermal experiments. I also try to do some crystallography here and there, along with structure interpretation with my students.

6. If exiled on a desert island, what one book and one CD would you take with you?

The book would have to be ‘Blood and Water’, a collection of stories by Tim Winton. I have forgotten how many times I have read this collection. These stories still captivate me; Winton has a truly laconic writing style and his characters transcend their often miserable lives with an undying spirit of hope. However, I doubt that any author can better an opening chapter than the one that begins ‘Fantastic Mr. Fox’ by Roald Dahl. I can still remember the day I first read this as a 6 year old and am taken back to my childhood every time I read it…to my kids. Happy days!

As for the CD… anything by Nick Cave and the Bad Seeds, and as I am limited to a choice of one then it would have to be their best-of compilation album. Nick Cave is a masterful lyricist.

Paul Kruger is in the Department of Chemistry at The University of Canterbury, New Zealand, and works upon all aspects of supramolecular chemistry ranging from organic synthesis and coordination chemistry, through materials and structural chemistry, to host-guest and sensor chemistry.

Posted by Neil Withers at 06:32 AM | Permalink | Comments (0) | TrackBacks (0)

As we finish up our 4th volume over at Nature Chemical Biology, we've been thinking about new ideas for the journal and new ways to follow up on some old ideas. We've also been getting some feedback recently that our decision letters (the 'reject', 'accept', or 'somewhere in between' emails) aren't as clear as they could be. Our editorial this month tries to shed some light on this issue, but I also thought I would ask you guys a few questions:

What is the ideal way to find out your paper has been rejected, if there is such a thing? Does it help if we explain our thinking - what aspects of the paper we found stronger or weaker than others? Or would you rather just hear 'no' and move on?

If we ask you to call us to talk about the decision, would you? If we ask you to expand the paper prior to review, when would you be willing to do that vs. just go to another journal?

How much do you all know about the editorial process generally? Meaning, do we need to explain that we do a first round of editorial review, or is that obvious?

Do you have any questions about decisions that we could discuss here? We do want our decisions to be as transparent as possible, both so that potential authors and editors can exchange ideas and have a deep understanding of the various fields we cover, and because it should save a lot of time and energy if we can make our editorial processes and criteria plain. So, please ask, explain, instruct! We're currently preparing the January issue, so we need some resolutions to work on.

Catherine (associate editor, Nature Chemical Biology)

Posted by Catherine Goodman at 04:15 PM | Permalink | Comments (10) | TrackBacks (0)

So, here I am in the Boston office of Nature Publishing Group....

My relocation, long foretold on our 'About the editors page', has finally happened. I've been looking forward to the move, but with some trepidation due to an anticipated large amount of form filling - complicated by the fact that I have to think carefully before writing a six-digit date!

As it turns out, the most difficult part was getting, not the visa, but the appointment for the visa application - ask me at a conference and I'll explain the details. My passage through US customs was also less time consuming than expected - taking no more than 20 min from landing at Logan airport to getting in a taxi to the office.

So down to the nitty-gritty of moving to a new country - in the last few days I've completed forms I-9 and W-4, signed up for 401(k) and several other things that also presumably have an alphanumeric code. In the spare time around the form filling, I managed to find a place to live - thanks to the wonder that is Craigslist.

Having got through what I believe to be the lion's share of the bureaucratic necessities, I can now work on the essentials. This morning, I looked up the values of nickels and dimes on Wikipedia - despite the many references to them in films, I was not sure of their actual value until today. The next thing on my list is to find somewhere to watch the football soccer - I don't understand american football yet, so any pointers will be welcome. Baseball is a little easier to follow, and as for hockey: "you mean ice hockey don't you?"

It's Thanksgiving soon, so I need to find a good recipe for pumpkin pie, or be nice enough to my new office mates to get an invite!

Steve

Stephen Davey (Associate Editor, Nature Chemistry)

Posted by Stephen Davey at 11:30 AM | Permalink | Comments (0) | TrackBacks (0)

Put the kettle on, settle down and read our Research Highlights.

The Born-Oppenheimer approximation simplifies the Schrodinger equation into more manageable pieces (unlike physicists, some of us have to deal with more than one electron...) and is pretty crucial for quantum chemistry. It doesn't always hold, however, but in some complicated physical chemistry we let Gav write about, it still holds up in reactions between hydrogen and chlorine.

Seeing as one day nanoscale people will be driving around in nanoscale cars, it's worth making sure that they won't be breaking the 2nd law of thermodynamics. Fortunately for everyone, it doesn't look like they will: a classical mechanical ratchet on the molecular scale just slows down, rather than going in one direction.

Molecular knots are normally tricky beasts to make - as you might expect - but now a method to make some by simply allowing silver ions and organic ligands to diffuse together takes only one step. Different length ligands produce different knots.

Neil

Neil Withers (Associate Editor, Nature Chemistry)

Posted by Neil Withers at 04:59 AM | Permalink | Comments (0) | TrackBacks (0)

1. What made you want to be a chemist?

I was a reasonable tuba player and had auditions to go to music college – these didn’t go too well and it was pointed out that I was quite good at maths and physical sciences. I thought again and decided that I enjoyed chemistry and was interested in research (whatever that was) so put chemistry down on my university application forms (as well as civil engineering, although I don’t really remember why now). I stumbled into the summer of my second year and found myself in Dave Leigh’s lab (then at UMIST) for a vacation placement and suddenly awoke to the enormous possibilities for making and playing with molecules. I guess that’s when I started to understand what it was I wanted to do.

2. If you weren’t a chemist and could do any other job, what would it be - and why?

It varies; when the national football team are not doing so well, I want the manager's job because I haven’t quite grown out of the habit of thinking I know what the best line-up and formation is. On other occasions, I’d quite like to act in West End Musicals as these are the most fantastic live entertainment and encompass acting singing and dancing. Some days, I’d like to be a house husband and stay home with my 1 year old daughter – time spent with her is more rewarding than anything else I do!

3. How can chemists best contribute to the world at large?

Develop the theories, synthetic methodologies and new chemists that permit society to continue to evolve. The scientific aspects cover: preparation/ degradation of recyclable materials, methods for energy collection and storage, purification of the atmosphere/ water and new challenges in healthcare such as an ageing population. I struggle with this one as there are so many fun reasons to do chemistry which we should endeavour to convey to those around us, but some of these issues are pretty big problems – for me it is not really a case of how chemists should contribute, more of what chemists must do or things could get quite sticky!

4. Which historical figure would you most like to have dinner with - and why?

This is not something I think about too often – and now I have, the list gets quite long quickly, not to mention that it’s made me start thinking if I’d prefer to have dinner with someone famous who’s alive. In any event, Leonardo Da Vinci would be quite good – my family were on holiday in Tuscany this summer on a vineyard close to the town where he was born. I was amazed at the diversity of activities he was involved in, particularly some of his engineering work which centuries later seems (to an untrained eye) to be largely unchanged. Tuscany was also very good for food and wine!

5. When was the last time you did an experiment in the lab - and what was it?

Today, I ran a couple of TLC’s, an NMR and an IR on a sample so that I had characterization for an undergraduate experiment I have to mark! More seriously, I was still doing a little synthesis last month for a paper that needs finishing off – I should stay away and let my group get on with laboratory work, but even though I don’t have time and I don’t think my group like it too much, I can’t resist the temptation to see if something will work for long.

6. If exiled on a desert island, what one book and one CD would you take with you?

Book: Lord of the Rings because it is good and because it is long, which will be helpful as I’m likely to have plenty of time. CD: Assuming the ready availability of a solar powered CD player; Symphony No. 2 Resurrection by Mahler, but Definitely Maybe by Oasis comes close. Can’t I have a whole i-pod?

Andy Wilson is in the School of Chemistry at the University of Leeds, and works on inhibition of protein-protein interactions, self-assembly and molecular recognition.

Posted by Neil Withers at 06:34 AM | Permalink | Comments (0) | TrackBacks (0)

Yesterday was the 5th of November, which means thousands — nay millions — of people in the UK spent last night looking up at drizzly skies going 'Ooooh!' and 'Aaaah!' at successive fireworks. It's all thanks to a plot 400 years ago to blow up the Houses of Parliament (or is it?)

Now, hands up all the readers whose formative experiences as chemists involve burning things? Thought so — me too! One of my lecturers took this further than most, however, and used to bring home-made gunpowder into lecture theatres to compare to commercial bangers. There wasn't much sleeping in HIS lectures — or people sitting on the front row.

So, fire, bangs, colours - what more could one want? Think of all that chemistry that's going on... Thanks to a few excellent websites, I now know that strontium and lithium salts are responsible for red, calcium for orange, sodium for yellow, barium for green, copper for blue and iron is gold (eh?). The crackling showers of white sparks are created by titanium flakes: the noise is caused by the thin layer of oxide cracking as the metal inside melts. Thousands of years since they were first invented, gunpowder is still used to provide both the whizz of the flight and the bang of the subsequent explosion.

All this might seem pretty simple (C + S + KNO₃) stuff, but I remember from Dr Ludman's course just how complicated the reactions were — and how hard to balance in the homework! And all those tightly packed solids give off [relatively] vast volumes of gases in a splurge of energy and entropy.

So the next time you see some fireworks — real or not — spare a thought for the creative chemists with some of the best jobs in the world.

Neil

Neil Withers (Associate Editor, Nature Chemistry)

Posted by Neil Withers at 09:29 AM | Permalink | Comments (0) | TrackBacks (0)

Time for another dose of Research Highlights - we scour the literature so you don't have to...

First up, would you expect ionic liquids to separate into layers of anions and cations on surfaces? At first glance, you'd probably think they'd mix it around to balance the charge - but not if the surface is charged, as is the case.

Next we have some 'double metallocenes' - rather than just one Cp (or indeed Cp*) ring above and below the metal, these have two fused Cp* rings sandwiching two metals. In the 250-word article, I didn't have space to go into the full story of the magnetic, electronic and redox properties investigated, so you'll have to go over to JACS for the details.

Serendipity...not just a good name for a cat or a posh word for luck. Where would chemistry be without it? In this case, without a method for 'fixing' fingerprints. While trying to make sulfur nitride polymers Paul Kelly and colleagues noticed that the precursor, disulfur dinitride, was so reactive that it was even reacting with the fingerprints on the glassware...and you can imagine the rest!

Neil

Neil Withers (Associate Editor, Nature Chemistry)

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