The last day of an ACS meeting is weird. Lots of people have gone already, so the cavernous convention center starts to feel a bit empty. On top of that, everywhere you look people are dismantling all the conference stands, pulling up the carpet, and, for some reason, wrapping up displays in cling-film. It reminded me of a restaurant I went to once, where I was trying to finish my dessert but the waiters were putting their coats on and turning off the lights.

It's been a great trip, but I'm ready to go home. My abiding memories will be:

An analytical speaker, who claimed that he loved mass spectrometry, then peppered his talk with phrases like "Mass spectrometry tells lies" and "Mass spectrometry data is like having a map of hell".

Another guy describing an assay with fruitflies, in which he described the fruitfiles that couldn't learn to avoid electric shocks as 'Republicans'.

The lady who spiced up her talk by showing a picture of herself dressed as a salt cellar, with a large strawberry on her head. (There was a very good reason for this, but there's not enough space here to explain.)

So, farewell to Boston - here's hoping, like Katherine, that British Airways have some functional planes. Oh, and can the last person to leave the convention center please remember to turn the lights off?

Andy

Andrew Mitchinson (Associate editor, Nature)

Posted by amitchinson at 04:37 PM | Permalink | Comments (0) | TrackBacks (0)

That's it, I'm off. I've had a great week, as ever the conference didn't fail to surprise, impress (and exasperate). All good ingredients for a productive few days. I assume the delegates were equally as productive. We'll find out in New Orleans in March, I suppose.

Hopefully I'll make it home on time - please British Airways... I am anticipating a huge welcoming committee.

Posted by Katharine Sanderson at 03:20 PM | Permalink | Comments (0) | TrackBacks (0)

Even though there are reportedly 14,000 people at this meeting, I'm always amazed at how small the chemistry community can be. I've bumped into lots of my ex-colleagues from when I was in industry, and they all have different stories to tell.

Some of these people are working in the pharmaceutical industry, which is having a tough time at the moment. There's a lot of anxiety about jobs, which seems particularly cruel given that some of these people have only just recovered from being made redundant elsewhere.

Still, big pharma seems to be doing a lot better than agrochemistry. A friend of mine who used to work in that area says that there are very few agrochemistry R&D presentations at this meeting, which basically reflects the state of the industry. Genetically modified crops and lower price margins have taken their toll, and the industry seems to be in real decline.

Finally, some thoughts from a process chemist. He comments that there seems to be no appreciation of environmental concerns in most of the lectures that he's seen. Green chemistry is a noble thing, but he says that the simplest way of helping the environment would be to phase out certain solvents - such as dichloromethane or benzene. At least one big pharma company will be doing this in the next few years. My friend believes that the top academic chemists should set an example by using more environment-friendly solvents, but they rarely do.

What do you think? Do the big name chemists have a responsibility to be green?

Andy

Andrew Mitchinson (Associate editor, Nature)

Posted by amitchinson at 12:06 PM | Permalink | Comments (1) | TrackBacks (0)

It's the last day of the conference, a sleepy atmosphere pervades the air. Or at least my head, which has up until now been filled with worms - but you'll have to pick up a copy of Nature next week to find out why I might be investigating worms at a chemistry conference. The suspense is unbearable, I know...

I saw some talks on antibiotics today. Resistance to antibiotics has one good thing going for it, that's for sure - chemists and biochemists are always going to be in a job. Talking to Gerry Wright after his talk really brought this home - we might find a way to beat drug-resistant bacteria, but the bugs are constantly beavering away working out ways to beat us back in return.

Posted by Katharine Sanderson at 11:45 AM | Permalink | Comments (0) | TrackBacks (0)

There was a new session in the medicinal chemistry session today, called Hot topics in medicinal chemistry. I spoke to the session organiser, Jeff Zablocki, about the motivation for the session - he wanted to get industrial parties to come and talk about new results. This wasn't easy, he said, but he managed to pull together a session with five different companies come and talk about early results for five different drugs.

One of the talks was by Thais Sielecki, from Cytokine PharmaSciences. She was showing us new preclinical data for a type of molecule based on small molecule inhibitors of macrophage inhibitory factor, MIFs. Her impressive data showed that their orally-delivered drug could halt MS symptoms in mice, and actually show improvements in some symptoms. Sielecki told me that for a small company like Cytokine PharmSciences, a chance to present data like this is great for getting business partners. Of course there was a large chunk of data - such as the structure of the actual product - that she didn't show, but I noticed lots of furious scribbling going on in the room anyway.

It's always going to be hard to get pharma companies to disclose information, but Jim McCarthy, programme chair for the Med Chem division is planning to encourage more openness - with the introduction of a session at the next meeting for companies to make first announcements about clinical compounds in medicinal chemistry. And take up has been good so far he says. But he knows that there will never be any disclosure of new target molecules. "This is industry" he says. Intellectual property rights will always keep peoples' mouths clamped tightly shut.

Posted by Katharine Sanderson at 08:18 PM | Permalink | Comments (1) | TrackBacks (0)

This week has driven me slightly insane, for a number of reasons. Included in those reasons is the vastness of the conference. We all say it, year in, year out and I've been trying to bite my lip. But really, ACS - can we have a conference that doesn't involve half-hour bus trips between venues?

Now that's off my chest let me tell you about ionic-liquid marbles. I saw some incredibly cool videos of droplets of ionic liquid being rolled in PTFE powder, and then forming marbles which are very hydrophobic and have amazing floaty properties on water surfaces. The work is being conducted by Tom McCarthy and Lichao Gao at the University of Massachusetts.

Some of the marbles they made were magnetic and could be dragged around - with potential for drug delivery. The coating of the marbles is held in place by magic. Well, actually, it is held in place by electrostatic forces (but I thought I'd inject a bit of children's storybook fantasy into this post), and this means that when an electrostatically-charged rod - rubbed on a pair of nylon trousers or something like that - is brought near the marbles, they pop! And in drug delivery this could mean them being dragged to a target using the magnet, and then being allowed to release their bounty with the stroke of a charged wand...

Posted by Katharine Sanderson at 02:42 PM | Permalink | Comments (3) | TrackBacks (0)

Yesterday, I popped along to hear Roald Hoffmann (again) talking at his own birthday symposium. Also there was author and neurologist Oliver Sacks, who is not a chemist, but when I met him this morning was wearing a very natty periodic table t-shirt. It was in colour, much better than my white-on-red version. Note to self - update wardrobe.

Back to the facts. Roald Hoffmann got a Nobel prize for some very clever theoretical chemistry and some rules that explain, and can be used to predict, why and how reactions proceed. But his first published paper was actually on the thermochemistry of cement. Fascinating.

Oliver Sacks has not only a periodic table t-shirt, but he told me that for the past 60 years has carried a periodic table in his wallet as well. I don't think it has been the same one all that time, because it was in very good condition. And haven't they added umpteen elements in the past 60 years.

Posted by Katharine Sanderson at 10:49 AM | Permalink | Comments (1) | TrackBacks (0)

Quick, hurry over to booth 434 in the exhibition hall, you still have 42 minutes to get your entry in to win an iPod so that you can listen to the Nature chemistry podcast... Hurry! The draw will be made at 11 AM.

Posted by Katharine Sanderson at 10:18 AM | Permalink | Comments (0) | TrackBacks (0)

As much as I've enjoyed my forays into analytical and flavour chemistry, yesterday afternoon I had a relapse and attended the Arthur C. Cope session on organic chemistry in the cathedral-sized ballroom. Actually, the cathedral analogy doesn't seem a bad one, as sometimes it does feel as if there's a certain amount of worshipping going on.

I really enjoyed this session because it had an ecelectic mix of topics. Highlights for me included Kenneth Shea's talk on how to build polyethylene molecules from single-carbon units, in a living polymerization reaction involving ylides and diazoalkanes. In this way, he's made some unusual polymers - such as chains with high steric congestion that can't be prepared using traditional methods for polyolefin preparation.

I also liked Leonard MacGillivray's presentation on solid-phase organic reactions. He co-crystallizes pairs of organic compounds to form lattices in which hydrogen-bonding aligns the molecules in a perfect orientation for reaction - specifically, photodimerization reactions between alkenes to form cyclobutanes. Because the lattice holds the molecules in very specific orientations, the stereochemistry of the process is precisely controlled.

But my favourites were Dave Macmillan and Andre Charette. Charette described his work on the preparation of chiral amines by adding organozinc reagents to N-phosphinoylimines. Now I've always been a bit dubious about dialkylzinc compounds, because they're a pain to make. But Charette has thought of this, and has developed a relatively simple way to make them from zinc methoxide - so top marks for thinking of the practicalities.

MacMillan discussed his work on SOMO-activation reactions using organocatalysis. I liked the way that he gave much of the credit for this idea to his co-worker, Teresa Beeson. His group are currently developing new reactions using SOMO-activation, so expect to see enantioselective alpha-halogenation of aldehydes, vinylation reactions, and the enentioselective alkylation of cyclic ketones (which apparently requires a completely different catalyst to the one currently published).

All in all it was a top session. The only down-side was the way that people in the audience would get up and leave as soon as the speaker they were interested in had finished. I know that people have to focus on lectures in their own fields to get the most out of these meetings, but if they'd stuck around for the whole session I think they'd have found the variety of topics refreshing and stimulating.

Andy

Andrew Mitchinson (Associate editor, Nature)

Posted by amitchinson at 08:45 AM | Permalink | Comments (0) | TrackBacks (0)

Like Catherine, I'm a bit behind on scientific posts - so here's a quick recap of some of the talks I attended earlier in the week.

My Sunday morning started with an excellent session on malaria/anti-malarials - Solomon Nwaka from the World Health Organization's Special Programme for Research and Training in Tropical Diseases 'kicked off' the session with a broad overview that really drove home why malaria is (still) such an important disease: every 30 seconds a child dies from malaria, and the disease is responsible for more that one million deaths each year. Anti-malarial drug resistance is a huge problem (and there aren't that many new drug candidates in the pipeline), so the session focused on several academic scientists who are searching for new drug candidates. This is often done as a collaboration with Medicines for Malaria Venture, a non-profit organization created to “discover, develop and deliver new antimalarial drugs through public-private partnerships.” (For more information on public-private partnerships, click here and here).

I was only able to stay for the first half of the session, but I heard Jonathan Vennerstrom talk about synthetic peroxide anti-malarials (including this simplified analog of artemisinin) and Paul O'Neill talk about analogs of amodiaquine that were active against drug-resistant strains of malaria (click here for a recent review on 4-aminoquinoline anti-malarials).

The debate about whether or not academic scientists should try to get involved in drug discovery can get quite heated (see Derek Lowe's take on it here; you might also be interested in this NRDD 'Outlook'). Though I understand why some scientists think that academics should avoid this area of research, many pharmaceutical companies aren't willing (or able) to pursue a drug discovery program that focuses on malaria or other important, yet neglected, infectious diseases that disproportionately affect developing countries. (NITD and GSK are important exceptions to this general rule...)

So my question is if many pharmaceutical companies aren't willing/able to tackle these problems, why shouldn't academic groups give it a try?

Joshua

Joshua Finkelstein (Senior Editor, Nature)

Posted by Joshua Finkelstein at 08:26 AM | Permalink | Comments (1) | TrackBacks (0)

Here's a bit of gossip - Avogadro's constant, the one that lets you work out how much is in a mole of something, is under threat from a bunch of physicists who want to see it declassified as an absolute number, and instead tied to Planck's constant, which is altogether more complicated to explain but essentially is used in quantum mechanics to bunch things into packets, or quanta. Not very clearly explained, but I'm no physicist. Check out other definitions here and here.

The person who told me this shocking piece of news is a member of the ACS nomenclature committee. Before you all rush out and try to recalculate the number of moles in your morning coffee - don't panic. My source tells me that on a practical day to day basis, there will be no change, although explaining moles to a tenth-grader will be more difficult if the change ever makes it through.

The paper that started it all was apparently published in the journal Metrologia, by Ian Mills, although I'm having trouble tracking down the paper.

From my brief conversation, it seems that the idea is to relate Avogadro's number to Planck's constant so that the number becomes a relationship between the two numbers rather than an exact number. The grandiose phrase I heard was that this would relate Avogadro's number to the invariants of nature. What would happen in your world if suddenly you had to redefine Avogadro's number? Anything? Nothing?

Posted by Katharine Sanderson at 09:09 PM | Permalink | Comments (4) | TrackBacks (0)

One of the great things about ACS meetings is the incredible breadth of topics that are covered. In my quest to learn about branches of chemistry that are unfamiliar to me, this morning I attended a session of the division of agricutural and food chemistry. To be precise, the lectures were all about interactions between taste and smell.

I've always been intrigued by flavour chemistry, and the way that the body senses chemicals and interprets them as smells and tastes. So this session was a real eye-opener. I have to say that there wasn't much that you could really describe as chemistry - not a chemical structure in sight, in fact. But here are some interesting factoids that you might be interested in.

First off, have you ever stopped to think about why some smells seem sweet or sour, when sweet and sour are tastes? Its all to do with associations in the brain. The associations become so hard-wired that if you smell something like strawberry while you're eating something sweet, then the taste becomes sweeter. And if you smell caramel while you're eating something bitter, the taste seems less bitter. Perhaps most remarkably, sweet smells can even improve your tolerance to pain.

The attention you pay to a taste can also affect your enjoyment of that taste - the more you try to analyse a flavour, the less you enjoy it. Which suggests that professional wine tasters enjoy wine less than joe public. And one final thought - if all this is true, then coffee will smell different depending on whether or not you use sugar. Speaking of which, it's time for my latest caffeine fix...

Andy

Andrew Mitchinson (Associate Editor, Nature)

Posted by amitchinson at 05:35 PM | Permalink | Comments (0) | TrackBacks (0)

Continuing my proud tradition of not blogging in real time at ACS meetings, here are my memories of a lovely Sunday:

I went to my first ever session in the chemical toxicology division, which was a session on zebrafish organized by Peter Dedon. Knowing a bit about his background (in DNA structure/damage/etc), it was quite a surprise to find Dr. Dedon bringing this group of people together; it turns out that the simple explanation is: scientific curiousity. How delightful.

Leonard Zon gave the first talk about using zebrafish as a model system for stem cells, some of which (that prostaglandins increase the number of stem cells in bone marrow) was recently published. In some of his new work, he's discovered a pre-cancer phenotype (a cell cluster) as well as a molecule that can reverse the clustering. As comes as no surprise, we didn't get to see the structure of the molecule.

Patricia McGrath* gave a very informative talk about zebrafish in general, and outlined some of the ways that her company can monitor what these fish are up to for screening applications. She also gave out plastic fish, to the delight of everyone except the people who arrived too late to get them. There was also randomly a plastic fish sitting next to me - hard to know whether it was there just to get information, or perhaps to protest animal testing? In any case, it made for a good neighbor.

John Stegeman gave a great talk which highlighted the importance of carefully thinking through your biological model system: he's found that there are significant differences in the cytochrome P450's in zebrafish vs. humans; this is important because these Cyp450's are the enzymes that process drugs and other foreign molecules, meaning that bioavailability and identity of any metabolites could be quite variable.

The final speaker, Jackie Lees, closed out the session by discussing cancer in fish.( Who knew??) She's discovered an interesting correlation between cancerous cells, the presence or absence of p53, and ribosomal proteins. While their initial theory was that the ribosome was just not producing p53, it seems there may be more complicated mechanisms at work.

Overall, it was a really good session. And fish (plastic or otherwise, except for the ones with electrodes in their heads) are cute.

In other chemical toxicology news, Joanne Kotz (the senior editor at Nature Chemical Biology) has organized a session in the same division on Thursday morning, focused on understanding the full scope of what drugs do, including intended and unintended interactions. If any of you are still around that day, check it out!

Finally, I need your help: I was walking out of the convention center, and passed a room labeled 'CHED - DUCK'. I glanced in and all I could see was people eating ice cream. Can anyone explain?

Catherine Goodman (associate editor, Nature Chemical Biology)

* I can't seem to find a website for either Dr. McGrath or Phylonics, the company. However, I was amused to discover that if I just searched for 'McGrath', this website was the first result. Coincidence? Or a convenient way to get rid of the test subjects?...

Posted by Catherine Goodman at 11:50 AM | Permalink | Comments (0) | TrackBacks (0)

I have just worked out that, since saturday afternoon, all my meals have been sandwiches for one reason or another, although I almost ate a slice of cold pizza at one point, but didn't want cheese-related nightmares so declined. I have broken the cycle now thanks to a chocolate croissant in the press room.

My mind turns to food because a major thread of this conference is the genomics of obesity. In particular I was interested to learn that human adenovirus-36, known to be the "obesity virus", has now been shown to turn stem cells into fat cells. Magdalena Pasarica at the Pennington Biomedical Research Center and Nikhil Dhurandhar from Louisiana State university, took stem cells from the fatty tissue from a bunch of liposuction patients. Half of the batch of stem cells were exposed to Ad-36, and half not. The virus-infected stem cells developed into fat cells.

So does this mean, as long as I don't get the virus, that I can happily eat my chocolate croissants without worry of becoming obese? Or am I missing the point?

Posted by Katharine Sanderson at 10:15 AM | Permalink | Comments (0) | TrackBacks (0)

I only have time for a quick post, but I wanted to mention a few other blogs/bloggers that are at the fall ACS meeting - most of you know that Paul and Kyle are here, but it looks like journalists from C&EN and Chemistry World are blogging from the meeting (including Carmen Drahl, who used to post at She Blinded Me with Science/who now works for C&EN...)

It also looks like Mitch (from Chemical Forums) and Eric (from Homebrew and Chemistry) are here too... Have I missed anyone? If so, please add a link to their (or your) blog in the 'comments' section of this post...

It sounds like some of these bloggers will be at John Harvard’s Brew House in Harvard Square tomorrow night. I'll try to swing by for a round (and will see if I can convince any of the other NPG editors to join me) - hope to see you there...

Joshua

Joshua Finkelstein (Senior Editor, Nature)

Posted by Joshua Finkelstein at 09:14 AM | Permalink | Comments (1) | TrackBacks (0)

Ah, the poster session. I like these things; they have allowed me to perfect that useful social skill of marching up to strangers, thrusting a hand out in the hope it will be shaken, and saying "Hi, I'm Katharine. Who are you?" Once in a while the tactic pays off and you learn something incredibly interesting.

Tonight's session was slightly marred, not for the first time, by the realisation that members of the press had not been issued with drinks tickets. I had experienced this at the previous ACS meeting so should have anticipated it. Instead i had to charm one of the posterees into donating one of his tickets. In return i got to learn about rotaxanes that can be stacked up to make switchable liquid crystals, in a very elegant piece of chemistry. This is the first controlled, switchable liquid crystal to be made, and no surprise that the work, done by Ivan Aprahamian (thanks for the beer Ivan) comes out of the lab of Fraser Stoddart. The work was recently published.

The poster also had a molecular carousel - an incredibly complicated molecular machine with three "axes" joined at top and bottom each holding a ring that can move up and down, independently of the other rings. Hard to describe, but a carousel, where the rings represent the galloping horses, is a good analogy.

My favourite title of the evening has to be "highly absorbing superabsorbent polymers" by Thilini Mudiyanselage, from Bowling Green State University. These are hydrogels that can absorb thousands of times their own dry weight in liquid. The lightly cross-linked 3-D polymer nets expand a lot after soaking up all that water.

As usual, a huge mix of chemistry was showcased at the poster session - from a system that gets rid of bird poo, to a poster called "Girls in science" - bet you can't guess what that was about - and try saying it without using a Muppet-esque "Pigs in Space" voice...

Posted by Katharine Sanderson at 10:48 PM | Permalink | Comments (2) | TrackBacks (0)

I'm an organic chemist at heart, but for this meeting I've decided to explore beyond the wonders of total synthesis. So this morning, I attended one of the analytical chemistry sessions - and it was fascinating.

I opted for a session on metabolomics. For those of you who think this sounds like a rude word, let me tell you that it's the study of metabolites as markers for disease (or at least that's one application; it's impossible to do justice to the full range of possibilities in one blog entry).

The session began with a talk by Lily Tong, from Greg Stephanopoulous' lab. They were able to identify metabolites that are upregulated in patients that die of kidney failure. In this way, they were able to devise an accurate model to predict patients at most risk from the disease. Impressive stuff.

Rima Kaddurah-Daouk described a study of plasma taken from people with schizophrenia, and showed that each of three commonly-used antipsychotic drugs produces its own pattern of lipid-metabolite perturbation. This provides further evidence of the so-called 'lipid hypothesis' of schizophrenia, which suggests that the disease is not just caused by disturbances to neurotransmitters.

And finally, the award for gross presentation of the day goes to Andy Ewing, who is using fruitflies as models to study the effects of alcohol intoxication and dependence. This involves harvesting fruitflies' heads, and we were treated to some lovely pictures of his special fruitfly-head masher in action.

It's been a while since I looked at how metabolomics is progressing, and I was impressed at how far the field has come over the last few years. And now that I know fruitflies get drunk, I'll never look at them the same way again.

Andy

Andy Mitchinson (Associate Editor, Nature)

Posted by amitchinson at 05:36 PM | Permalink | Comments (0) | TrackBacks (0)

I recently wrote a feature about storing hydrogen gas in incredibly porous materials (shameless bit of self promotion there, but one needs to keep the fans happy). But now I'm wondering whether I got it all wrong - a talk today by Bob Crabtree raised an interesting point - the motoring industry has an infrastructure that is all set up to revolve around liquid fuels, so why go after hydrogen as a fuel if one keeps it in the gaseous state?

Crabtree has a strategy to store hydrogen as a liquid, by using organic liquids that have readily-releasable hydrogen. In this case he has studied, both experimentally and computationally, nitrogen-containing cyclic molecules. The amount of nitrogen present can be changed so that the temperature at which hydrogen can be released is also changeable. There is much to say on this topic, I feel... but for now I must run - the monster-sized poster session is happening this evening and I'm hoping for a bit of excitement.

Posted by Katharine Sanderson at 04:45 PM | Permalink | Comments (0) | TrackBacks (0)

I think I've just encountered the highlight of my visit - a poetry reading by Nobel prize-winning chemist Roald Hoffmann.

Coincidentally, I've been thinking a lot about poetry lately, and how a poet can convey their thoughts. I am not brave enough to attempt to write anything other than a jaunty limerick myself, so I have a good deal of admiration for anyone who can convey a complex thought in an abstract, but senseful way.

And Hoffmann just spent an hour in the middle of a busy, bustling exhibition hall, packed full of people trying to sell mass spectrometers and the like, with a crowd of people captivated by his poems that cross from hard-core science to his childhood experience growing up in Poland during the war, to more philosphical matters. Check out the next issue of Nature's chemistry podcast, when it hits your ears in a few weeks to hear more.

Posted by Katharine Sanderson at 01:21 PM | Permalink | Comments (1) | TrackBacks (0)

Space is big. You just won't believe how vastly, hugely, mind-bogglingly big it is. I mean, you may think it's a long way down the road to the drug store, but that's just peanuts to space.

This Douglas Adams quote was one of the first things that popped into my head when I entered the Boston Convention & Exhibition Center. Simply put, the building is huge: "516,000 square feet of contiguous exhibit space" with "3 exhibition halls each ranging in size from 162,000 to 184,000 square feet."

After looking at the floorplan, I realized that it would be pretty tough to rapidly hop from session to session - the convention center has two skybridges that you need to use if you're moving from the west side of the building to the east side of the building, so it can take 10 to 15 minutes to get from one session to another. This must be why the refrigerator in the press office was packed full of bottles of Gatorade/Powerade...

The first day of the ACS was great (more about the science in my next post), but I've yet to find a good place to grab coffee that doesn't have a huge line at all hours of the day - on my way to the afternoon session I saw people crowded around a table containing snacks and coffee. Alas, the giant drum of coffee was decaf! I saw another table further down the corridor, but it too contained only decaf coffee. Oh cruel world, why must you mock me so?

Joshua

Joshua Finkelstein (Senior Editor, Nature)

Posted by Joshua Finkelstein at 11:00 AM | Permalink | Comments (0) | TrackBacks (0)

So, here I am , gathering news for Nature. Like Andy, I had a less-than smooth arrival, after being unceremoniously bumped off my flight last night. But here I am, a day late and raring to go.

I'll be blogging mainly on the news@nature.com site, so check back to get the latest from the conference floor...

Posted by Katharine Sanderson at 03:46 PM | Permalink | Comments (0) | TrackBacks (0)

People often say to me that travelling must be one of the perks of the job, but, oh boy, there are times when I beg to differ. I tried so hard to check-in online, but the British Airways system kept chucking me out. So I tried to use the electronic check-in kiosks at Heathrow airport, but after queuing for 30 minutes, the machine refused to give me a boarding pass. I was told to join a nearby queue for the actual check-in desks, where I waited for an hour, before being told that, actually, it was the wrong queue.

When I eventually got my boarding pass, I then had to stand in front of an x-ray machine in security, striking different poses (turn to the left, hands in the air, turn to the right, hands down...) I know security is important in these troubled times, but I couldn't help thinking that they were just making me dance the Timewarp in slow motion, and taking pictures of me in my underwear with their x-ray camera. I imagine the images will be on YouTube by now.

The plane was late, and once we'd boarded, we were told we'd have to wait for an hour for a take-off slot. Eventually we trundled to the runway, whereupon the plane immediately turned around and went back to the gate, because a passenger had taken ill. The stricken passenger was removed, and we had to wait for his luggage to be located in the hold and removed. Then the plane had to be re-fuelled, and we waited for another take-off slot. After three hours on the plane, we finally took off.

It could have been worse; some of my friends from the Royal Society of Chemistry had their flight to Boston cancelled. And at least I didn't have to watch any films about penguins this time.

Thanks for letting me get that off my chest - on with the ACS meeting...

Andy

Andrew Mitchinson (Associate Editor, Nature)

Posted by amitchinson at 12:59 PM | Permalink | Comments (0) | TrackBacks (0)

Well, the fall ACS meeting is nearly here - a few NPG editors will be attending the meeting (including myself), so don't forget to check back for daily updates...

I also wanted to mention that we've put together another special issue of Nature that will be distributed at the meeting - in this week's issue, there's a News Feature on metal-organic frameworks and several papers:

- Structure-based activity prediction for an enzyme of unknown function by Hermann et al. (click here for the News & Views)
- Vitrification of a monatomic metallic liquid by Bhat et al. (click here for the News & Views)
- A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines by Fortin et al. (click here for the News & Views)
- Selection and evolution of enzymes from a partially randomized non-catalytic scaffold by Seelig & Szostak (click here for the News & Views)

If you're going to be at the meeting, don't forget to swing by the NPG booth (booth #434) to pick up free issues of Nature, Nature Chemical Biology, Nature Materials, Nature Methods, Nature Nanotechnology, and Nature Reviews Drug Discovery.

And last (but certainly not least), Paul thinks we should meet for "[d]rinks or dinner at a neutral location" - depending on where and when it is, I'll try to swing by (and bring along a few of the other editors...) Hope to see you there!

Joshua

Joshua Finkelstein (Senior Editor, Nature)

Posted by Joshua Finkelstein at 03:14 PM | Permalink | Comments (0) | TrackBacks (0)

(ed's note: at the request of the GRC, this post has been removed.)

Catherine (associate editor, Nature Chemical Biology)

Posted by Catherine Goodman at 04:00 PM | Permalink | Comments (0) | TrackBacks (0)

(ed's note: at the request of the GRC, this post has been removed.)

Catherine (associate editor, Nature Chemical Biology)

Posted by Catherine Goodman at 02:26 PM | Permalink | Comments (0) | TrackBacks (0)

(ed's note: at the request of the GRC, this post has been removed.)

Catherine (associate editor, Nature Chemical Biology)

Posted by Catherine Goodman at 02:30 PM | Permalink | Comments (0) | TrackBacks (0)

This is my final blog from the RSC symposium on synthesis in organic chemistry, and it’s been great. The undoubted highlight came last night, when Ian Fleming (now an emeritus professor) gave a brilliant overview of his career, describing all the influences that culminated in his famous work on the use of silyl groups in organic synthesis.

Starting from his work as grad student, he presented the highs (and occasional lows) of his career with wit and candour. He began his working life in the 1950s, at a time when state-of-the-art spectroscopy meant IR and combustion analysis was often the linchpin of your analytical data. NMR had only just been invented and was only to be used “if you were desperate”, as he put it. And if you did get an NMR, you needed good eyesight, because the resulting spectra were smaller than dollar bills. Even a couple of decades later, 10 g of sample were still required for a carbon-13 NMR experiment.

It was a fascinating story, peppered with amusing anecdotes – for example, as a grad student, he had to cover all his samples with watch glasses, to stop his PhD supervisor from absent-mindedly tipping ash into them from his pipe. And it was fascinating to get the inside story of some of the historic achievements in organic chemistry – such as Woodward’s synthesis of vitamin B12.

Fleming spoke for 90 minutes and was rewarded with a standing ovation – not something that I’ve ever seen before at a chemistry conference. It was an evocative description of a bygone era, delivered by one of the last remaining gentleman chemists, and I felt privileged to witness it.

So, thumbs up to Cambridge. The next meeting in this series will be in two years time – I heartily recommend it, and I hope I’ll see you all there!

Andy

Andrew Mitchinson (Associate Editor, Nature)

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WARNING! This blog entry contains a joke with chemical content! Those of a nervous disposition may want to look away.

For those who didn’t read my last entry, I’m currently at an RSC symposium on organic chemistry, held in Cambridge (UK, not MA). It’s traditional for UK conferences to be held at universities, apparently so the delegates can be shocked at the quality of the food. Last night was particularly cruel, because all the tables were laid out with wine glasses, creating an expectation of alcohol. Sadly, no wine was actually forthcoming, so the delegates had to face the evening lecture unfortified.

Still, we’ve had some cracking talks. Today, Varinder Aggarwal presented some powerful chemistry for homologating boronic esters; this allows carbon chains to be ‘grown’ with control over the relative and absolute stereochemistry. This work has yet to be published, but he reckons the paper will be ready later this year - so keep your eyes peeled.

Shu Kobayashi discussed various topics in catalysis, ranging from scandium complexes that enable carbon-carbon bond formations to be performed in water (click here for an example), to lab-on-a-chip hydrogenations that are performed in channels coated with polymer-encapsulated palladium. And Dean Toste gave an overview of his work on gold catalysis – a truly amazing lecture, delivered with such aplomb and rapidity that it was difficult to tell when he drew breath.

So who told the chemistry joke? It was Amos B. Smith III, at the evening lecture last night. Dithiane groups feature heavily in his work, and he was questioned about the best way of removing them. This prompted the following gag:

Why are there 32 methods for removing dithianes?
Because none of them work…

Andy

Andrew Mitchinson (Associate Editor, Nature)

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I don’t seem to be having much luck at conferences recently. At the ACS meeting in Chicago earlier this year, I was given a hotel room without a bed. Yesterday, I turned up for an RSC symposium on organic synthesis and there wasn't even a room for me. At this rate, I’m assuming that when I arrive in Boston for the autumn ACS meeting I’ll discover that my hotel doesn’t exist.

Anyway, once the small issue of my accommodation was sorted out, I had a fun evening catching up with some familiar faces until very late in the night. I’m now experiencing that familiar conference feeling of being very tired but totally wired on coffee.

The lectures this morning kicked off in fine style with Steve Davies. You could hear the scratching of pens on paper coming from all around as he described lots of useful synthetic organic chemistry reactions (including an amazingly stereoselective variant of the Horner-Wadsworth-Emmons reaction – I’ll post the details of the paper once it gets published). Incidentally, I’ve commented before that chemists often seem to have splendid hair, but Steve’s must surely win all the prizes…

Another highlight was Ben List’s talk on new strategies in organocatalysis, including some very neat ideas on chiral Bronsted acid cataysis using phosphoric acid derivatives – see this paper for an example. Contributing to the truly international flavour of the symposium, Goverdhan Mehta from the Indian Institute of Science presented some of his total syntheses of biologically active natural products. Worryingly, he began by defending total synthesis, which he thinks is being marginalized – does anyone agree with him?

OK, that’s plenty for now, but I’ll update you on other interesting stuff tomorrow.

Andy

Andrew Mitchinson (Associate Editor, Nature)

Posted by amitchinson at 10:26 AM | Permalink | Comments (3) | TrackBacks (0)

(Editor's note: at the request of the GRC, this post has been removed.)

Joshua Finkelstein (Senior Editor, Nature)

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I'm not sure whether this technically counts as an ACS-related post, because I wasn't actually at the conference this day. But, I was at the University of Chicago, which would have been unlikely if I hadn't already been in Chicago for the meeting. And, this blog may be a bit rambling, which is due to the fact that I left my brain in Chicago, so it all comes together...

One extra fun thing about visiting the campus relates to some family history: my grandfather wanted to be a chemist, and actually spent some time as a graduate student at the University of Chicago before dropping out due to lack of funds. It was very interesting to think of what the campus must have looked like when he was there, or what he might have worked on. It also brings to mind some comments that I've heard in passing over the last couple of years; to sum up, it's the idea that scientific results only have to age by a certain amount before people forget about them, attempt the same (or almost the same) experiments again, and publish them as new information. Perhaps some poor graduate student will get their Ph.D. by figuring out what the length of time 'x' is that governs this phenomenon (and then the next poor student will write up the same report 'x' years later, and so on, and so on...)

While I was treated to some fascinating stories by Jun Yin, Chuan He, Sergey Kozmin, Joe Piccirilli, and David Lilley (who was also there visiting), what I most want to discuss here is the interesting lunch I had. Dr. Kozmin took me over to the faculty club, and specifically to the 'chemistry table.' Not surprisingly, perhaps, this consisted of a long table (~20-25 seats) where chemistry professors came and ate lunch, with later arrivals sitting further down the table, and so on, and so on. While I'm sure most departmental topics were curbed by my presence, there was lots of general discussion and just a sense of familiarity. On the way back to the chemistry department, I was chatting with Dr. Kozmin and our lunchtime neighbor, Robert Haselkorn, about this practice, and they both indicated that these lunches are a great way to discuss anything related to departmental affairs, and that in the end, the chemistry faculty don't need to have very many official faculty meetings because everything gets sorted out at lunch (or, perhaps, that issues that are raised in formal meetings but have been previously discussed rise from the ashes of the lunchtime conversations, much like their own beloved mascot?). I think this is a lovely idea, as it provides an opportunity to discuss things in a more casual way, and with less of a time limit (although I guess it's possible that if you don't go to lunch, you miss out on the decision-making).

I'm all for casual and comfortable discussions. Do you all know of other examples where faculty (or industrial teams, or similar) get together in a similar way? Do you wish that there were more opportunities like this, or do you like more formal meetings where everything's on the record? Or at least can you recommend some good faculty clubs? After all, I've got visits to plan...

Catherine (associate editor, Nature Chemical Biology)

Posted by Catherine Goodman at 06:50 PM | Permalink | Comments (1) | TrackBacks (0)

The extra challenge (for me and other chemical biologists or biological chemists or what have you) of the spring ACS meeting is that the biological section basically closes down. This year, the entire program was 5 sessions, which were actually all sponsored by another division. So while, at the fall meeting, it's quite easy to scoot around between enzymes, folding, imaging, etc. within a few pages of the printed program, the spring meeting requires some extra work to find sessions dealing with biologically-related questions.

Don't fret, though - the scientists who want to talk about these things are still a part of the meeting, and can be discovered in nooks and crannies of the other divisions. Kind of like how rampaging dinosaurs will figure out a way to overcome their female-only DNA to take over the world. Or, to imagine a different definition of that infamous line (in my blog title, you know), perhaps I mean that us Nature editors will still be able to locate these hidden sessions.

That last idea was certainly true for a great program put on by the CHED division, focused on 'Exploring and Exploiting Nature with Biomimetics'. Not only was this program part of an unusual division,* but it was set in a room in the basement of the North/South building at the end of a hall and around a corner, etc. Too bad there wasn't also a wardrobe to climb through to reach this magical land of graduate student-invited talks. I didn't get to see as many of the talks in these three sessions as I would have liked, but they were full of the heavy hitters in the field, including, for example: Ron Breslow, Julius Rebek, Larry Que Jr., Paul Wender, Laura Kiessling, Dirk Trauner... the list goes on and on. Wender gave a nice talk about function-oriented synthesis, in which the complexity of natural products is pared down to the minimum functionality required. In addition to simplifying the synthesis of these molecules, he suggests that we can use this process to better understand the function of the molecule, allowing the design of new (and even simpler) compounds. Eric Kool, on the other hand, is all about making things more complex. He is designing an orthogonal genetic system based on xDNA (expanded DNA, in which each base contains an extra ring). Once that works, maybe we can design some xDinosaurs?

Anyway, congrats to the graduate students for putting together such a great lineup. And now, I've mixed up enough pop culture references for one day.

Catherine (associate editor, Nature Chemical Biology)

* To be fair, the sessions were cosponsored by the Biological division, so I didn't have to look that hard.

Posted by Catherine Goodman at 03:10 PM | Permalink | Comments (0) | TrackBacks (0)

Well, I've never been one to follow the trend, so I decided to write about the ACS after it was actually over. Forget this real-time blogging stuff! (and if you're only reading this blog for the ACS content, keep reading for the next few days).

I wanted to offer my congratulations to Drs. Puglisi and Williamson for putting together a great series on the Biophysics of RNA. I went to 2 different sessions (both were outstanding), and the remaining sessions were always high on the list of the 5 concurrent sessions I wanted to go to. On Tuesday afternoon, I caught Dan Herschlag's talk, who "wants to set forth principles and physical organic parameters to make RNA folding less mysterious." And indeed, his talk was a great tour through different forces and conditions that need to be considered in elucidating RNA folding. He was also very gracious when I went up after the talk and asked, basically, "can you explain your whole field to me during the coffee break?" In fact, he and the other speakers I cornered got me pretty interested in the topic, so if I ever leave my current job you may find me back at the bench in an RNA lab.

Aside from just being nice people in general, the RNA crowd made a nice counterpoint to the person who found my phone and promptly downloaded nearly $300 worth of games (and as you can imagine, it wasn't in an attempt to spruce it up for me before giving it back...). I guess I'm learning to appreciate all those silly contraptions people have for keeping their phone nearby, as my track record with phones and the ACS isn't so great...

Well, here's hoping the next ACS organizers keep up the good work, or at least that I stop losing things...

Catherine (associate editor, Nature Chemical Biology)

Posted by Catherine Goodman at 09:42 AM | Permalink | Comments (0) | TrackBacks (1)

So the ACS conference is no more. Actually, it feels like it's been winding down since Tuesday, what with all the big banners saying "See you at the next meeting", the posters advertising taxi services to the airport, and people wandering around with their luggage. I think it's a shame that so many people have already gone home by the last day, especially for those who are still presenting. They may not be the biggest names, but it doesn't seem fair that their potential audience is reduced before they even start.

As I mentioned before, this was my first ACS, and I think it's lived up to expectations. I've enjoyed the chemistry (of course) but also the people watching. It seems that more senior chemists are predisposed towards facial hair (especially splendid moustaches), whereas the younger crowd are rebelling by generally being clean-shaved (although a trendy goatee beard is permitted).

Technology now allows for some mind-blowing multi-media presentations, but also inevitably to a random scattering of pop-up error messages. Still, I've enjoyed some of the visual humour. My favourite was the speaker who, when discussing the various organisms that have had their genomes sequenced, provided an image of each species. There was a picture of fruit-fly, a worm, and a chimpanzee. And right next to the chimp, representing humanity, there was George Bush. Say no more.

Anyway, I'll be flying back home tomorrow (oh joy, another 8 hour flight with nothing to do but watch films about penguins. Why is it always penguins?), and then I'm going to lie down in a darkened room for a week. Really.

Andy

Andrew Mitchinson (Associate Editor, Nature)

Posted by amitchinson at 06:39 PM | Permalink | Comments (4) | TrackBacks (0)