In the editorial in August’s Nature Chemical Biology, we share our thoughts on peer review. As you can imagine, the exact timing of an editorial on this topic coincides with the peer review trial and debate going on over at Nature, but the thoughts within the article (as well as many related ideas) are frequently on our minds. My most recent inspiration, however, comes from a trip to a convenience store to buy some toothpaste. The veritable cornucopia of choices (even within a single brand!) made me wonder: if we need 50 different kinds of toothpaste to satisfy what seems a fairly simple concept (of cleaning our teeth), how will we, in the face of an equally overwhelming number of choices, ever come to an agreement on a system as complex and important as peer review?