Nature Chemistry | The Sceptical Chymist

Time is on my side

I was just talking with Catherine, and we can’t remember if “a week in the library will save you a day in the lab” or if “a week in the lab will save you a day in the library”? I guess if you’re starting a new project, maybe it’s best to set up a whole bunch of experiments to see what works (steering clear of the dogma you’d find in published papers). But if you’re nearing the end of a total synthesis, you probably want to play it safe with your milligram/sub-milligram quantities of your natural product and spend a bit more time in the library trouble-shooting problems… 

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