Medicago’s proteomic profile

Medicago's proteomic profile

Legumes have the unusual ability to make their own fertilizer. They do this by associating with nitrogen-fixing bacteria, which take nitrogen from the air and convert it to ammonia that can be used by the plant to make proteins, nucleic acids and other essential molecules. Understanding the biology underlying the association between legumes and their symbionts could enable these concepts to be adopted in other types of crops as well. In a paper recently published in Nature Biotechnology, Joshua Coon and colleagues report the proteomic profile of the organs of a model legume, Medicago truncatula, and its collaborative partner, Sinorhizobium meliloti. Analyzing the proteomic atlas they generated together with transcriptome and genomic data, the researchers show how this resource can be used to discover new biological insights surrounding nitrogen fixation that may one day be useful for future crop engineering efforts.  Read more

Mitochondrial protein functions

Mitochondrial protein functions

Mitochondria are energy-generating organelles that carry a portion of their own DNA. Mutations in mitochondrial proteins are associated with metabolic disorders, neurodegenerative diseases and a variety of malignancies. Joshua Coon, David Pagliarini and their colleagues generated proteomic, lipidomic and metabolomic data on 174 strains of yeast, each carrying a mutation in a different protein implicated in mitochondrial function. In their paper in the November issue of Nature Biotechnology, they show how connections among these different data sets can be exploited to reveal new insights into the biosynthesis of coenzyme Q, an essential lipid required for oxidative phosphorylation. Their paper can be found here.  Read more

Bio-leaders of Tomorrow

Bio-leaders of Tomorrow

I first came across the GapSummit in November 2015. The meeting was organized by Global Biotech Revolution and was to be held April 2016 at Cambridge, UK. Looking at the agenda, I noted the Voices of Tomorrow competition, which aimed at getting all the participants to form groups and come up with possible solutions for the ‘gaps’ in the biotech sector, found in research and innovation, funding, future health, future resources, people, bioethics, and public perception & education.  Read more

Analyzing Global Biotech Investing Over Time

Analyzing Global Biotech Investing Over Time

Where are venture funds being deployed in biotech? Is this changing? As part of a programme to find out how VC interacts with biotech, I have created a database of venture investment in 33 countries and three regions of the USA, over the time periods before, during and after the financial crisis of 2008-11, and built this into an interactive map of the biotech VC world. The map is clickable, with data for each country linked to that country on the map. The link to the map is here.  Read more

Guidelines for algorithms and software at Nature Biotechnology

Guidelines for algorithms and software at Nature Biotechnology

Nature Biotechnology outlined its recommendations for material sharing and reporting for algorithms and software in a April 2015 Editorial. On this page, the editors provide more detailed information for authors submitting manuscripts containing unpublished algorithms and software.  Read more