ACS: Katharine the gourmand

I have just worked out that, since saturday afternoon, all my meals have been sandwiches for one reason or another, although I almost ate a slice of cold pizza at one point, but didn’t want cheese-related nightmares so declined. I have broken the cycle now thanks to a chocolate croissant in the press room.

My mind turns to food because a major thread of this conference is the genomics of obesity. In particular I was interested to learn that human adenovirus-36, known to be the “obesity virus”, has now been shown to turn stem cells into fat cells. Magdalena Pasarica at the Pennington Biomedical Research Center and Nikhil Dhurandhar from Louisiana State university, took stem cells from the fatty tissue from a bunch of liposuction patients. Half of the batch of stem cells were exposed to Ad-36, and half not. The virus-infected stem cells developed into fat cells.

So does this mean, as long as I don’t get the virus, that I can happily eat my chocolate croissants without worry of becoming obese? Or am I missing the point?

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My dry box is still better than your dry box

In the interest of getting chemists involved in the current phenomenon of reality TV, I have a few ideas of new shows that some silly network can use (although, on the off chance that they do, I’m claiming rights…)

Idea #1: Along the lines of Iron Chef (or really any competition show), there should be a chemistry showdown. Each chemist would be given a lump of coal and all the reagents, catalysts, glassware, etc. they want. Then, the first person who can get an NMR of a target molecule wins a prize. (A postdoc fellowship? Travel reimbursement for that conference in Greece? The use of a grant writer for that next R01? An R01?? (Maybe that’s the grand prize)) Of course, the molecule can’t be too complicated, as otherwise the show would potentially never end. The show could feature theme weeks, where instead of having eel or artichoke as the ingredient you must include, the chemists would be given morpholine, or undecanoic acid, or julolidine hydrobromide and have to work those molecules into the final product somehow. Alternatively, again given a certain starting molecule, the chemists could create as many distinct molecules as possible within a given time limit.

I think this would allow returning chemists to develop a big following, as viewers would get to know the chemists and what their preferences are for reactions and reagents (such as ‘oh, he’s reaching again for the osmium tetroxide! He does love to oxidize things.‘ or ’It looks like… yes! She is doing a Michael addition. What a clever use of the double bond.’ …)

What do you guys think? Would you watch?

Catherine (associate editor, Nature Chemical Biology)

2 thoughts on “My dry box is still better than your dry box

  1. Undergrad organic chem lab with community college tolerated minority pre-meds would be a hoot. Each week one vital component will be subtly… defective.

    “Why is there liquid amidst the white crystals of isopropyl ether?”

    Sudden death playoffs!

  2. See I was thinking along the lines of “The Next Top…” series. “The Next Top Postdoc.”

    8 postdoc wannabes face elimination each week in a competition to find Prof X’s next postdoc. Tasks could include presentations, glassware cleaning, grant writing, paper writing, best synthetic route to the target, fastest NMR interpretation…

    The competition could be fierce…lots of riveting chemist-geek-speak and backstabbing gossip out of hours. Who has the skills to make it as a postdoc in the lab of Prof X, who will be "the next top postdoc " cue video montage of clips of stars having lab disasters, Prof X frowning discouragingly and scenes of jubilation…

    …and back to work I go.

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