Say hello to Warp Drive Bio, stay tuned for details

This new company, Warp Drive Bio, is being funded by Sanofi and Third Rock Ventures, a biocoastal venture capital firm with a big footprint in Kendall Square.

The only links on the Warp Drive Bio  web page take you to emails for “careers’ and “contacts.” Here’s the description from the press release.

 About Warp Drive Bio

Warp Drive Bio is driving the reemergence of natural products in the era of genomics to create breakthrough treatments that make an important difference in the lives of patients. Built upon the belief that nature is the world’s most powerful medicinal chemist, Warp Drive Bio is deploying a battery of state-of-the-art technologies to access powerful drugs that are now hidden within microbes. Key to the Warp Drive Bio approach is the company’s proprietary “genomic search engine” and customized search queries that enable hidden natural products to be revealed on the basis of their distinctive genomic signature. Launched in 2011 through a groundbreaking strategic partnership with Sanofi and with financing from Third Rock Ventures and Greylock Partners, the company was founded by renowned scientist Dr. Gregory Verdine, along with Dr. George Church and Dr. James Wells.

Line here to the full press release and a here for a story from the Boston Business Journal.

Here’s a link Third Rock Ventures. If you get dizzy easily, you might want to skip the intro, which zooms into a Google-worldish maps of  “Boston’ — mostly Cambridge, actually — and San Francisco.  One of their Cambridge companies is currently involved in lawsuit over potential cancer cures. More on that here.

 

NatNews: Q & A w/ MIT’s Nancy Hopkins

Nature News offers a Q & A interview with  MIT’s Nancy Hopkins. See our report on her recent speech here and a video of another below.

What motivated the landmark 1999 study that you championed on gender bias at MIT?

It was a final straw. At age 50, after 20 years as a scientist, I found that it was impossible for me to get the supplies and lab space I needed to do my work. I thought, ‘I’m not going to tolerate this any more’. I told another woman, and she said she was experiencing the same thing. We talked to other women scientists at MIT and realized that we were all hitting the same roadblocks.

What was the reception like from your male colleagues when you began to speak out?
It was not too good. Some in my department were downright hostile and that was a problem for me. But suddenly I had eight women and four men on the study committee, and also Robert Birgeneau, then dean of science, whom I could actually talk to about this.

Reports like this often fall on deaf ears. What made the difference here?
We put in a huge amount of work, 5 years, just to try and understand the scope of the problem, before we wrote the report. The internal report on which the 1999 report was based was very long, and detailed enough that if you were a scientist and read it, you could see how what was happening to us would make your life as a scientist very hard. It was also a miracle that Charles Vest [then president of MIT] realized that there was a problem and was willing to publicly endorse the report.

Upcoming events including Bill, Ted and CERN

Check out this week’s events on our calendar and see our new listing of ongoing events.

Plan ahead, however, for next offering from Science on Screen, the only institution that could linke Bill, ted and CERN. Check out previous posts for more on the Coolidge Corner Theatre series and past screenings.  

With only a few days left before their high school graduation, two most excellent dudes, Bill S. Preston, Esq. (Keanu Reeves) and Ted “Theodore” Logan (Alex Winter), are on the verge of flunking history.

Unless they can ace their final history report, Ted’s dad will pack him off to a military academy in Alaska, meaning their band…

Join us before the film as Edward Farhi, a most excellent professor of physics at MIT and director of its Center for Theoretical Physics, unravels the oddities of time travel and weighs in on the question: Is travel through time physically possible? Dr. Farhi has studied the complexities of building a time machine, though not of the phone-booth variety. His current interest is the theory of quantum computation. He was on the staff at the Stanford Linear Accelerator Center and at CERN in Geneva, Switzerland before coming to MIT, where he joined the faculty in 1982.

More this week here:

New Yorker, BIDMC on the mystery of the placebo effect

Michael Specter of The New Yorker has a piece on Program in Placebo Studies and the Therapeutic Encounter at Beth Israel Deaconess Medical Center .

 The program was formed to explore an idea that even twenty years ago would have seemed preposterous: that placebos—given deliberately—might be deployed in clinical practice. As medicine. … The research has been propelled in large measure by the emerging discipline of neuroimaging. In several recent studies, placebos have performed as well as drugs that Americans spend millions of dollars on every year.

If you don’t have a subscription, check out the follow-up on Radio Boston  or Commonhealth.

There’s growing evidence that placebos can actually help cure people, or at least make them feel better. If true, this could spark a major revolution in medicine, because traditionally placebos have had a bad name. After all, they’re usually a fake pill, nothing more than a bit of sugar, for example, designed to deceive people in clinical drug trials.

 

New Kendall Square restaurant set up to host bio events like this one

When new drug development company H3 decided to throw a party to launch the opening of Kendall Square labs and offices, organizers didn’t have to go very far. They took the elevator downstairs.

Last week, local researchers, bio boosters and lots of men in dark suits from the Japanese drug company Eisai gathered in the trendy meetings room at the new Catalyst restaurant.

Floor to ceiling windows overlook a landscaped concrete plaza that joins the cluster of new and renovated mid-rises known as Technology Square. The landlord, lab developer Alexandria Properties, chose the restaurant — and the former chef of now closed Aujourd’hui — with meetings like this one in mind. Thus, 1,900-square-feet of meeting space behind the dining room can be split up into the Crick, Franklin and Watson rooms. (The rest of the restaurant is farm-to-table chic, with panelling made of old barn boards a “two-way fireplace” encased in glass.)

Before the ribbon cutting, waiters worked their way through the crowd with minted oysters on the half shell and tuna tartar. Slides with information about the H3—for “human, health and hope” — looped on two flat screens embedded in the blonde wood siding.

Betting on an approach emerging from the Broad Institute labs, the company plans on “integrating human cancer genomics with next-generation synthetic organic chemistry and tumor biology.” In other words, they plan to use genetic insights gleaned from actual cancer patients to identify therapeutic targets.

H3 Biomedicine is not your standard startup. Rather than seek out venture capital, the company arrives as a subsidiary of Japanese drug maker Eisai. In turn Eisai, which makes anti-cancer cancer drugs along with an epilepsy treatment, has invested $200 million into H3. Many gathered at the event had “Eisai” on their name tags and company president Haruo Naito flew in for the champagne toast. Click here’s for Mass High Tech’s take on the event.

Angus McQuilken, a spokesman for the Massachusetts Life Sciences Center, told the group that “If you stand in Kendall Square and throw a rock in any directions, you’ll hit a world class scientist.” Two of them are H3’s “scientific founders” Dr. Stuart Schreiber and Dr.Todd Golub, both of the Broad. The website Xconomy describes them as “scientific luminaries.”

More from that site.

 

H3 aims to discover small molecule drugs that target weak points in tumors that have been uncovered through genetic studies of people’s cancers. Fittingly, both Golub and Schreiber are founders of the Broad Institute of MIT and Harvard, one of the largest genomic research centers in the world. Schreiber, an expert at synthesizing drug compounds to home in on disease proteins, has been a founder of numerous biotech companies such as Vertex Pharmaceuticals and more recently Forma Therapeutics. Golub, a fellow scientific founder of Forma, is an authority on the genetics of cancer.

Always worth noting that much of the seed money that allows the Broad researchers to move into drug discovery comes from the feds. The National Institutes of Health database reports that for 2010 and 2011, Golub is working with grants worth $9 7 million, which included about $4 million for the Broad Cancer Center. Schreiber lists $22.3 million in grants, including $15 million money for including Broad comprehensive screening program

Is Kendall Square getting too hip? MIT adds to the boom

The Globe has a story on MIT’s plans for Kendall Square, which describes the school’s backyard as “urban desert, with unused spaces and buildings isolated by wide streets, exaggerating the sense of emptiness.”

That view is a little dated as the bleak landscape made huge progress on the cool curve this summer. In addition to a burst of new restaurants, add this to support that conclusion — it was hard to find a parking space on a recent Thursday night.

Read more of the Globe story here.

Or, take a look yourself:

NYTimes: Profile and video interview w/ Harvard’s Steven Pinker

This Times profile is getting a lot of ink. Check it out.

(For more on the other side of Pinker’s controversial ideas about gender and the brain, check out this New Yorker story ($) about his nemesis, Elizabeth Spelke. Or see this video of their debate.)

On Pinker, Carl Zimmer writes:

As a young professor at the Massachusetts Institute of Technology, he pored over transcripts of children’s speech, looking for telling patterns in the mistakes they made as they mastered verbs. Out of this research, he proposed that our brains contain two separate systems that contribute to language. One combines elements of language to build up meaning; the other is like a mental dictionary we keep in our memory.

This research helped to convince Dr. Pinker that language has deep biological roots. Some linguists argued that language simply emerged as a byproduct of an increasingly sophisticated brain, but he rejected that idea. “Language is so woven into what makes humans human,” he said, “that it struck me as inconceivable that it was just an accident.”

Instead, he concluded that language was an adaptation produced by natural selection. Language evolved like the eye or the hand, thanks to the way it improved reproductive success. In 1990 he published a paper called “Natural Language and Natural Selection,” with his student Paul Bloom, now at Yale. The paper was hugely influential.

Click here for the video.

At UMass Amherst, skulls tell the tale of evolving bats

UMass Amherst news office has a release on a study looking at bats skulls:

“This study conducted during the International Year of the Bat offers a clear example of how the evolution of new traits, in this case a skull with a new shape, allowed animals to use new resources and eventually, to rapidly evolve into many new species,” (Elizabeth) Dumont (of UMass) says. “We found that when a new ecological niche opened up with an opportunity for bats that could eat hard fruits, they shifted their diet significantly, which in turn led to the evolution of new species.”

bat skuls.jpg

The skulls and faces of a nectar-eating bat (left) an insect-eating bat (middle) and a fruit bat (right). The short skulls of fruit bats allow them to bite harder than nectar or insect-eating bats.

Photos courtesy of Elizabeth Dumont, University of Massachusetts Amherst