Announcing the winners of the #ScientistAtWork photo competition

Thanks to everyone who took part in the inaugural Naturejobs photo competition

This week in Nature, we announce the winners of the Naturejobs #ScientistAtWork photo competition. Here are the photos that won. You can also check out Nature‘s podcast for a further interview with the final winner of the competition, Kseniia Ashastina. You can also check out Nature India‘s own excellent photo competition here.

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Kseniia Ashastina’s winning entry — a researcher collects samples from a permafrost outcrop {credit} Kseniia Ashastina {/credit}

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Method of the Year 2016

As is our tradition every year we have chosen a method, or in this case a set of methods, that have experienced rapid growth in the last years. This year’s choice of epitranscriptome analysis does not comprise a single technique but is based on advances in detecting, enriching and profiling base modifications on all RNA species.

Some of these modifications are abundant and have known functions, others are rare and their role is still obscure. We believe recent methodological advances, as detailed in a Review by Chengqi Yi and colleagues, lay the groundwork for a comprehensive profiling of some of these marks that will shed light on their role in the cell.

Our selection of methods to watch highlights areas we think will experience growth in the coming year and be influential in biological research: from global metabolomics, to RNA-targeting CRISPR, to elucidating single cell function and faster brain imaging.  We do not claim to provide a comprehensive list and our choices may be biased by our fields of interest. We do hope you enjoy reading this feature and if you disagree with us, or if you think we have overlooked an important area, please let us know.

Ten top science career tips for 2017

Top tens are very much a theme of the last issue of Nature for 2016. They include images of the year, 10 people who made a mark in science this year, and a review of the year in science. Naturejobs also gets into the “listicle” spirit by trawling through a year of articles to bring you our ten top career tips (and a few more thrown in for good measure) for the coming year.

1. Want to learn how to design an experiment or analyse data? Training is there if you look.

nj7622-703a-i1Scientific irreproducibility — the inability to repeat others’ experiments and reach the same conclusion — is a growing concern.

Much blame is placed on weak experimental and analytical practices that cause researchers to inadvertently favour exciting hypotheses.

Monya Baker reports.

In a separate post for Naturejobs, Monya runs through some of the statistical tools she discovered as part of her research. Continue reading

The astrophysicist on a mission to get more women into physics

Guest post by Alex Jackson

Professor Jo Dunkley

Professor Jo Dunkley{credit}Wadham College{/credit}

“Very often the famous names we know and read about in science are not those of women,” says Professor Jo Dunkley. “To get more young girls studying the subject, we must change cultural perceptions and have more visible female role models.”

As we sit discussing the women who have inspired Dunkley, a professor of physics and astrophysical sciences at Princeton University, to study the universe, the mood is rather sombre. On a morning when the first female frontrunner for US presidency has missed out at the final hurdle, and the impacts of that decision on science, are yet unknown, there is a strong sense of disbelief.

“I was really hoping to see the first female president and that in itself is a disappointment,” she says. “I don’t see it as a positive turn of events in terms of funding for science, although I hope there’ll be enough influence to keep ongoing projects running.”

Dunkley admits to being shocked at the result. Having moved from the UK, just shortly after Brexit, she was already starting to see the effects of political uncertainty on European grants. “Uncertainty is not we need right now in science,” she says.

However, the astrophysicist has plenty occupying her mind other than politics. This week, she will receive the Royal Society’s Rosalind Franklin Award and present a public lecture in London. Named after the great English chemist and crystallographer, the award recognises both her research in the cosmic microwave background, and her work encouraging more young women to study physics.

“I see a really important part of my work is not just doing the research I love, but also encouraging others to pursue a career in science,” she says. Dunkley became aware of Franklin’s story when she was an undergraduate at Cambridge University. Sadly, Franklin died at just 37 years old, the age Dunkley has recently turned. “She’s such a wonderful role model, who achieved so much in a very short life.”

Our window on the universe

Dunkley’s own research has gained her much attention. As a research fellow at Princeton, she worked on NASA’s WMAP satellite, before analysing data on the European Space Agency’s Planck satellite. Interrogating rich and complex data, her research group made large strides in furthering our understanding of the universe’s origins.

Studying the evolution of the universe is, however, becoming easier as technology rapidly develops. “Our telescopes have become so sophisticated in recent decades, we are now able to see out into the far reaches of the universe,” Dunkley says. “We’ve been able to put together a fairly successful cosmological model that explains how we got here over the 14 billion year history of the universe.”

A large focus of Dunkley’s work involves turning recorded maps of the most distant light we can see—an image of the universe when it was born—into properties such as age, weight, and the rate of expansion.

“We measure the faint light by capturing a little snapshot of what the universe looked like when it was only 400,000 years old,” she explains. Her team then compare the experimental data to millions of theoretical universes, until they find one which matches. “We can now see the very beginnings of tiny cosmic structures that over billions of years develop to become the first stars and galaxies. It’s then our job to find out what these structures look like, and how they evolved,” she says.

After analysing more than 15 months’ data from Planck, Dunkley and her colleagues created the most detailed map ever made of the oldest light to shine through the universe. The results confirmed many of the theories cosmologists draw on to explain the evolution of the universe. “We think during the first trillionth of a second of the Big Bang, the universe expanded extremely fast, laying down the seeds for the cosmic structure we see today,” she says.

A view of the cosmic microwave background collected by the European Space Agency’s Planck satellite.

A view of the cosmic microwave background collected by the European Space Agency’s Planck satellite.{credit}European Space Agency, Planck Institute{/credit}

By Dunkley’s own admission, there are still many unanswered questions. Her current research at the Atacama Cosmology Telescope in Chile, and a new five-year project at the same site in the Atacama Desert called the Simons Observatory, hope to make the next big steps forward in measuring cosmic microwave background.

“We keep looking for new physics, complexities and extra particles that could have existed when the universe was very young,” notes Dunkley. “Yet, the more data we collect, the simpler the universe’s behaviour looks, which is exciting, but we still have all these unanswered questions.”

After the breakthrough LIGO discovery earlier this year, which detected gravitational waves, Dunkley believes there’s much optimism in now finding a signal from the big bang. She also hopes through another development, gravitational lensing, scientists will soon be able to understand and map out where all the dark matter is in our universe.

Role models

Her optimism and love for physics is affable and evident in her responses. Yet, there is one area she believes cultural changes are needed: role models. This is a theme she will address in her lecture and one that will feature in her first popular science book out late next year, Our Universe: An Astronomer’s Guide.

“There really aren’t enough women role models in physics, and many of the great female astronomers are not often that well known, or talked about in education,” says Dunkley. “I think it is so important. The ability to see someone you can imagine being, is everything, and gives you the confidence to try things out and aim for something. And often that will mean having someone, as a woman, showing a woman can do it.”

Galaxies in our universe

Galaxies in our universe{credit}NASA, Hubble{/credit}

As she enthuses through the great achievements of Henrietta Swan Leavitt, “an incredible woman” who made it possible for Edward Hubble to determine that the universe is expanding; Cecilia Payne-Gaposchkin who figured out how stars were formed; and Vera Rubin whose work led to the theory of dark matter, it’s easy to forget Dunkley has become a star in her own right.

Dunkley may feature on shows such as BBC’s Science Club and Stargazing Live, yet she believes the industry must do better. “The media must do more to get visible female role models on television to change perceptions,” she says. “I’d love to get to the stage where young people knew it was normal to be a female scientist, and expect to be able to have a family too, whether it be in physics or engineering.”

Time for change

On academia, Dunkley is keen to express some sanguinity. “We’re definitely seeing more women now at senior level, which makes a huge difference, and has a direct influence on female students,” she says.

At Princeton, she notes there are growing numbers in female students pursuing astrophysics. It was a similar trend at Oxford University, where until this summer, Dunkley taught for more than eight years.  However, it is the drop-out rate at colleges that worries her.

“In the UK, for example, only 20 percent of physics students aged 16-18 are girls, and this figure continues through to degree, PhD, and researcher level,” she explains. It is a target she’d like to see change. “Consciously or unconsciously, there is often still a common assumption that science, particularly physics, is more for boys than girls. To effect change, we need to influence both teachers and parents.”

Through her book release, she is a planning a series of workshops, talks and videos for students, as well as a public lecture tour of the UK. She hopes to raise awareness of women’s contribution to astronomy, as well as break down the idea that the universe is too difficult to understand.

“I want to promote the many remarkable women who have been central to our biggest discoveries in space,” she says. “We have an incredible group of women currently working in the field, but to answer our world’s most pressing questions and challenges, we need more.”

Professor Jo Dunkley’s Rosalind Franklin award lecture will be streamed live on Thursday, 6.30pm GMT / 1.30pm EST.

Sharing research in three minutes: A shorter timeframe to see the bigger picture

Joshua Chu-Tan

Joshua Chu-Tan{credit}Jane Duong{/credit}

Joshua Chu-Tan is a second-year PhD student in the Provis Group at the John Curtin School of Medical Research at the Australian National University (ANU).

His presentation of his thesis, “Targeting the Root of Vision Loss”, won him top prize at the ANU’s Three Minute Thesis (3MT) competition. This event challenges PhD students to present their research in three minutes to a non-specialist audience. Joshua also went on to win the 2016 Asia-Pacific 3MT, which drew 50 contestants from six countries.

We ask him about his research and his experience competing in the 3MT.

1. Tell us about your research. What is its significance and what are your main findings?

Age-Related Macular Degeneration (AMD) is the leading cause of blindness in developed countries with a global cost of over US$340 billion per year. Our group looks at the dry form of AMD, which accounts for 90% of all AMD cases. This happens when light-sensitive cells deteriorate, causing a loss in central vision. There is currently no cure.

We work on gene therapies for dry AMD using microRNA. These molecules are masters in gene regulation: a single microRNA molecule can bind to multiple targets, all of which often work within the same cellular pathway. In this way, we can theoretically regulate entire pathways, rather than single genes. This could prove fruitful for complex, multifactorial diseases such as AMD.

I’ve been able to characterise a number of microRNA in our AMD model and through injections of a specific anti-inflammatory microRNA into the eye, we’ve seen a decrease in inflammation, as well as a slowing in the damage progression of the retina, which has been very promising.

Joshua Chu-Tan speaking at the 2016 Asia-Pacific 3MT competition

Joshua Chu-Tan speaking at the 2016 Asia-Pacific 3MT competition{credit}University of Queensland{/credit}

2. How did you hear about the Three Minute Thesis (3MT) competition and why did you choose to enter?

In 2015, I went to watch the ANU 3MT finals. The experience was phenomenal: hundreds of people came to watch students from all departments and faculties condense years of work into a three minute pitch. The interest that people outside of academia showed was inspiring and as I listened to all these brilliant students talk about the bigger impact of their work, I was enthralled. The whole time I was there, I kept thinking of ideas for my own 3MT—I knew I had to give it a crack.

3. Why do you think events like the 3MT are important? What did you gain from your involvement?

I believe the value of science communication is often overlooked in research, especially medical research. As researchers, we’re often invested in a single aspect of a holistic problem, which can result in tunnel vision within our niche. The work we publish uses highly specialised jargon, which is necessary for us to discuss specific problems, but isn’t very accessible for the general public.

Participating in events like the 3MT give us an avenue to convey our work to people outside of our field. We can take a step back and look at the bigger picture: Why should people outside of this field care about our work? What’s the real goal? Even the process of writing a speech for something like the 3MT is rewarding in that it gets us to consider these questions.

The ANU and Asia-Pacific events were also incredible opportunities for me to find out about other people’s research from around the world and consider new ways of looking at a problem. I really think the future of research will be interdisciplinary. We’re all trained to look at a problem in our particular way, but there’s only so much we can achieve within our specialties. Having experts from different fields approach a challenge together will greatly benefit research.

Winning the Asia-Pacific 3MT

Winning first prize at the Asia-Pacific 3MT{credit}Joshua Chu-Tan{/credit}

4. Do you have advice for other students preparing for a 3MT event?

  1. Enjoy it! It’s not an easy task and there will be nerves but really enjoy the moment, be confident in yourself, and take pride in your research.
  2. Only mention the key points of your work and make the audience relate to it. Write it like a story with a beginning, middle and end, and be true to yourself and how you would like to present it.
  3. At the events, truly listen to everyone’s work. Soak in all the amazing research that’s being conducted by your peers. This journey wouldn’t have been as rewarding if it wasn’t for everyone I met along the way.

5. What’s next for you?

With the Asia-Pacific win, I now have the incredible opportunity to attend and present at the Falling Walls Lab/Conference in Berlin. It’s a chance to rub shoulders with the world’s brightest minds so I intend to make the most of it.

After this remarkable 3MT journey ends, it’s full steam ahead to complete my PhD with a bang. I intend to stay in the field and attain fellowships that will allow me to complete my postdoctoral training overseas. Hopefully I can then return to Australia to contribute towards the strong research environment here.

You can watch Joshua’s winning 3MT speech, “Targeting the Root of Vision Loss”, here.

Founded by the University of Queensland in 2008, 3MT events are now hosted by over 400 institutions across six continents. The 2016 Asia-Pacific 3MT was sponsored by Springer Nature.

An open approach to Huntington’s disease research

Guest post by Rachel Harding, postdoctoral fellow at the Structural Genomics Consortium, University of Toronto, Canada

Rachel Harding

{credit}Rachel Harding{/credit}

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a mutation in the huntingtin gene1. The progressive break down of brain neuronal cells in HD patients leads to deteriorating mental and physical abilities over a 10-20 year period prior to death, the symptoms often described as having Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis (ALS) simultaneously2. At the start of the huntingtin gene there is a CAG trinucleotide repeat region that encodes a stretch of poly-glutamine residues in the amino-terminus of the encoded protein. This repeat tract is expanded in HD patients. The repeat length of this region correlates with the age of symptom onset3. Affecting approximately 1 in 10,000 of the population4, rare juvenile forms of the disease exist in patients with the longest CAG expansions, although adult-onset HD patients typically have between 40-50 CAG repeats with symptom onset beginning between the ages of 35-50. Continue reading

Data Matters: Interview with Ben Lehner

Ben Lehner

{credit}Ben Lehner{/credit}

Ben Lehner is a group leader at the EMBL/CRG Systems Biology Research Unit, in Barcelona, Spain.

Could you briefly introduce your own research?

My lab works on genetics, essentially. It’s a mixture of producing our own data, and using other people’s data. We’re a combined wet and dry lab, and we work with organisms and data from bacteria, through yeast, worms, all the way up to human clinical genetic data.

Broadly, how open do you think the human genomics community has been to sharing data?

I think there is a cultural history here that’s important. You can divide the human genomics community into two groups. Continue reading

Ada Lovelace Day: The women in science who inspire us – Part 2

Ada Lovelace Day aims to raise the profile of women in science, technology, engineering and maths by encouraging people around the world to talk about the women whose work they admire. We asked staff from across Nature Research who has inspired them.

This is the second of two blogs we’re posting today to mark this milestone (the first part is here). You can read more about Ada Lovelace’s legacy here.

Mariette DiChristina, Director, Editorial and Publishing, Nature Research Magazines, and Editor in Chief of Scientific American

Mariette

Journalists aren’t supposed to be partial. But I have to say I’m inspired by Elizabeth Blackburn of the University of California, San Francisco. For starters, in 2009 she shared Nobel Prize for Medicine or Physiology with Carol Greider and Jack Szostak for pioneering the understanding of telomeres and telomerase, which affect so many aspects of human health.

Dr. Blackburn tells wonderful stories about growing up with a love of science, and how her Nobel Prize-winning research began in studies of an organism that lives in the scum of ponds (“it’s very cute,” she says).

She’s supported women in science throughout her career. As a woman with more than a touch of imposter syndrome myself, I’ve been grateful to experience that encouragement first-hand.

Back in our Manhattan offices, one of the conference rooms is named Blackburn after her. I always smile when I enter it, happy to be reminded of one of the amazing women of science.

Francesca Cesari, Chief Biological Sciences Editor, Nature

Fran

Rita Levi Montalcini has been a great influence in my decision to become a scientist – as a student, before even deciding to study biology, I read her book “Elogio dell’imperfezione” (in English “In praise of imperfection”) over and over.

Forced out of university in 1938 by fascist race laws due to her Jewish background, she endured great hardship, but persevered in her scientific endeavours. She worked from her home ‘laboratory’ in Turin and then Florence, carrying out research on neurodevelopment.

In 1986, she was jointly-awarded the Nobel Prize in Physiology or Medicine with fellow biochemist Stanley Cohen for their discovery of nerve growth factor. At the time of her death in 2012, aged 103, she was the oldest living Nobel Laureate. She has been a great inspiration for many women in science.

Andrea Taroni, Chief Editor, Nature Physics

Andrea

Chien-Shiung Wu was a Chinese-American nuclear scientist who performed one of the most spectacular physics experiments of the past century. In 1956, she showed that the weak nuclear interaction – the force that is responsible for radioactive decay – does not obey parity symmetry. In other words, the laws of nature are not completely symmetrical.

Wu’s experiment confirmed a theoretical prediction made by Tsung-Dao Lee and Chen-Ning Yang, and caused a sensation at the time – the laws of nature had widely been assumed to be symmetric. Lee and Yang were awarded the Nobel Prize the very next year, in 1957. Even at the time, the fact that Wu did not receive a share of the prize was widely viewed as a gross injustice. Nevertheless, what I find truly inspiring about her is her insight into the inner workings of nature.

Helen Pearson, Chief Features Editor, Nature

Helen

Margaret Llewelyn Davies was an early campaigner for women’s rights and a social scientist of her time. Her deeply moving book, called Maternity Letters from Working Women, revealed the shocking conditions in which working women gave birth just over one hundred years ago.

Her work laid the groundwork for the maternity leave and benefits that women receive today. I came across it when I was researching my own book, The Life Project, published earlier this year. I’m indebted to her, and many other campaigning women, for creating a society in which I can combine children, born healthily and safely, with a job in science and writing – even if we still have a very long way to go to find full equality between men and women in our lives and careers.

David Barnstone, Press Officer, US, Nature Research

David

Alexandra Horowitz and Lisa Guernsey and are two outstanding women in the sciences. They are both social scientists who have progressed our understanding of the minds of two different species: dogs and children.

Horowitz studies canine cognition at Barnard College, one of the world’s oldest women’s colleges and affiliated with Columbia University. It was founded in 1889 because of Columbia’s refusal to admit women at the time.

Guernsey is deputy director of the Education Policy program and director of the Learning Technologies project at the New America Foundation, where she translates the latest research into policies to give all children the opportunity to lead happy and productive lives in an ever-changing world.

I admire both Horowitz’s and Guernsey’s ability to make research accessible and compelling to the general public, which inspired me to pursue science communication.

Smriti Mallapaty, Science Writer and Associate Editor, Partnership and Custom Media

Smriti

Before Elinor Ostrom challenged the idea, shared natural resources were seen as ‘tragedies’, and would always lead to their destruction. In a persuasive essay published in Science in 1968, American ecologist Garret Hardin argued that “freedom in a commons brings ruin to all”. The only way to save these limited resources from destruction was through privatisation or government regulation.

Ostrom offered an alternative account, in which communities did a better job than governments, companies or private individuals in sustainably managing shared resources. She proved this over several decades of fieldwork, studying farmer-managed irrigation systems and community forestry in Nepal, as well as fishers, pastoralists and foresters throughout the world.

In 2009, she became the first woman to win the Nobel Prize in Economic Sciences. The award recognised her achievements, but also drew attention to the success of decentralised forest governance in Nepal. It also inspired many stories on agriculture, land tenure and community forests in Nepal, especially for science and environment journalists like myself. Ostrom died of pancreatic cancer in 2012.

Ada Lovelace Day: The women in science who inspire us – Part 1

Ada Lovelace Day aims to raise the profile of women in science, technology, engineering and maths by encouraging people around the world to talk about the women whose work they admire. We asked staff from across Nature Research who has inspired them.

 This is the first of two blogs we’re posting today to mark this milestone.  You can read more about Ada Lovelace’s legacy here.

Abigail Klopper, Senior Editor, Nature Physics

Abigail

Ewa Paluch is the sort of scientist I would have liked to have been. Her work on cell shape changes has led to a deeper understanding of how intracellular mechanics impacts cell migration and division.

But more than the work she does, I admire the way that she does it. Her lab is a healthy blend of biologists, chemists, physicists and computer scientists — and what she lacks in house she happily seeks through collaboration.

Ewa actually trained as a physicist, so she understands that physiology can’t be decoupled from physics. But her immersive approach means that she’s also sensitive to the questions that her fellow biologists want answered — something that tends to get lost in translation in interdisciplinary research. She subscribes to a new school of biophysics that capitalises on quantitative techniques and theory, and blurs the boundary between disciplines.

Sir Philip Campbell, Editor in Chief, Nature

Phil

 For several years, we at Nature Research have run annual awards for outstanding scientific mentoring – two prizes per year, for lifetime achievement and for mid-career achievement. The nominations have been inspiring – there are people out there who are not only exceptional researchers but also exceptional sources of nurturing and inspiration for subsequent generations.

To celebrate Ada Lovelace Day, I want to highlight the past winners who are women. They inspire me but, above all, they have evidently provided great critically-minded guidance and inspiration to their graduate students and postdocs, who have themselves gone on to do fine things inside science and beyond.

Happily, this year’s competition has provided yet further female sources of inspiration, with some exceptional female nominees. Unfortunately, I cannot reveal the winners until the announcement in late November.

So congratulations – again! – to previous winners: Cliona O’Farrelly, Michela Matteoli, Barbara Demeneix and Rachel Webster.

Erika Pastrana, Team Leader, Nature Communications

Erika

Cori Bargmann is an outstanding scientist and an inspirational leader. She has made seminal contributions through her work in the genetic and neural mechanisms that control behavior in the nematode Caenorhabditis elegans. Bargmann and her colleagues have identified genes that affect animals’ responses to specific odors and discovered the circuits responsible for their chemosensory behavior.

Bargmann has received many awards and honors for her work, and more recently, has been one of the key leaders of the advisory committee for the NIH’s BRAIN Initiative. Here she has shown a unique capacity to bring scientist together, to develop a vision and to lead. Last month it was announced that Bargmann had been appointed the incoming president of science at the Chan Zuckerberg Initiative (CZI).

I have met Cori several times, and seen her in discussions that set the framework of the BRAIN Initiative. I believe she is an inspiration for women – and for all scientists around the world.

Liesbet Lieben — Senior Editor, Nature Reviews Disease Primers

Liesbet Lieben_picture

When being asked to write about inspirational female scientists, Jennifer Doudna and Emmanuelle Charpentier immediately come to mind.

By combining their strengths in microbiology and structural biology, they both have had an instrumental role in the discovery of the CRISPR-Cas9 system — a tool that can be used to change genetic material (DNA) with extreme precision and speed.

I’ve seen first-hand how the CRISPR-Cas9 system has transformed the way we do scientific experiments in the lab, and I can’t wait to see how it will revolutionise medicine.

Although there are still hurdles to overcome, this gene-editing tool shows great promise to cure diseases caused by mutations in DNA, such as cystic fibrosis. 

Elisa De Ranieri – Head of Editorial Services, Nature branded journals

Elisa

Dame Athene Donald springs to mind whenever someone mentions women in science. Throughout my studies she has inspired me and many others by being a champion of equality and diversity, in an area (physics) that is traditionally male-dominated.

Athene’s research bridges physics, biology and medicine. She and her eclectic team apply a range of concepts and techniques of soft matter physics to understand biological materials. Her career achievements stand out both for her scientific contributions as well as for her involvement in gender issues.

She is a Fellow of the Royal Society and was awarded the L’Oreal UNESCO for Women in Science award for Europe in 2009. Athene was also the Director of the University of Cambridge’s Women in Science, Engineering and Technology Initiative, and the University’s Gender Equality Champion, as well as a member of the European Research Council’s Working Group on Gender Balance.

Jill Adie, Science Communication Product Manager, Researcher Services

Jill

When I finally read the dog-eared copy of Dorothy Crowfoot Hodgkin’s biography a friend gave to me – foolishly not until after my PhD – I found myself in awe of her vibrant intellect, drive and resilience.

Her work laid the foundations for my own research. Dorothy studied the structure of biological molecules using a technique called X-ray crystallography, which was in its infancy at that time. She was incredibly passionate about what she did, and is credited with discovering the structures of penicillin, vitamin B12 and insulin. This led to a Nobel Prize in Chemistry in 1964.

Her aptitude and track record in determining 3D structures meant that during her career Dorothy worked alongside and mentored eminent scientists – she had a stellar academic career, but it was hard won. Even with the advent of World War Two, the demands of a busy family life, and the inherent difficulties of working in male-dominated academia, Dorothy continued to work on the subject she loved, and she remained scientifically active into her old age.

Part 2 of this series will be published today (11 Oct) at 17:00 BST / 12:00 EDT.