New Synopsis with ‘Visual Titles’

Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entryThe clock gene circuit in Arabidopsis includes a repressilator with additional feedback loopsCompeting pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting

Molecular Systems Biology has recently updated and streamlined its article Synopsis format (see example in Orr et al, 2012).

Each research article is now accompanied by a Synopsis box that includes an illustrative graphic, which we call a “Visual Title,” along with a short description of the main findings of the work. The Visual Titles are designed to provide, at a glance, an intuitive illustration of the general topic of the work. Featured articles on our main homepage have always been highlighted with graphics of this nature, but now every article will be permanently accompanied by a Visual Title.

The Synopsis format has also been substantially streamlined—we have eliminated the longer “Extended Synopsis” text summaries, and have moved the Synopsis to the beginning of the full text article page, rather than on a separate page.

Synopses will thus provide a concise and attractive overview of the key points made in a paper. We hope you will enjoy this new feature.

What is your top 2011 MSB paper?

Below is a list of the top 10 most read research articles published in Molecular Systems Biology in 2011, based on combined HTML and PDF access.  The work by Saeidi et al, in particular, received widespread media coverage for making a practical first-step toward fighting infections with engineered microbes (e.g. at Science NOW, Ed Yong’s blog at Discover Magazine, Nature, and TheScientist).

What is your personal top article of 2011?  Please post your comments below.


01

Article

Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen
Nazanin Saeidi, Choon Kit Wong, Tat-Ming Lo, Hung Xuan Nguyen, Hua Ling, Susanna Su Jan Leong, Chueh Loo Poh & Matthew Wook Chang

02

Article

Predicting selective drug targets in cancer through metabolic networks
Ori Folger, Livnat Jerby, Christian Frezza, Eyal Gottlieb, Eytan Ruppin & Tomer Shlomi

03

Article

Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques
Wan-Lin Su, Robert R Kleinhanz & Eric E Schadt

04

Report

RNA sequencing reveals two major classes of gene expression levels in metazoan cells
Daniel Hebenstreit, Miaoqing Fang, Muxin Gu, Varodom Charoensawan, Alexander van Oudenaarden & Sarah A Teichmann

05

Article

The essential genome of a bacterium
Beat Christen, Eduardo Abeliuk, John M Collier, Virginia S Kalogeraki, Ben Passarelli, John A Coller, Michael J Fero, Harley H McAdams & Lucy Shapiro

06

Article

Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast
Christian Miller, Björn Schwalb, Kerstin Maier, Daniel Schulz, Sebastian Dümcke, Benedikt Zacher, Andreas Mayer, Jasmin Sydow, Lisa Marcinowski, Lars Dölken, Dietmar E Martin, Achim Tresch, Patrick Cramer

07

Report

The quantitative proteome of a human cell line
Martin Beck, Alexander Schmidt, Johan Malmstroem, Manfred Claassen, Alessandro Ori, Anna Szymborska, Franz Herzog, Oliver Rinner, Jan Ellenberg & Ruedi Aebersold
(see also Nagaraj et al)

08

Article

Network modeling of the transcriptional effects of copy number aberrations in glioblastoma
Rebecka Jörnsten, Tobias Abenius, Teresia Kling, Linnéa Schmidt, Erik Johansson, Torbjörn E M Nordling, Bodil Nordlander, Chris Sander, Peter Gennemark, Keiko Funa, Björn Nilsson, Linda Lindahl & Sven Nelander

09

Article

Proteomic snapshot of the EGF-induced ubiquitin network
Elisabetta Argenzio, Tanja Bange, Barbara Oldrini, Fabrizio Bianchi, Raghunath Peesari, Sara Mari, Pier Paolo Di Fiore, Matthias Mann & Simona Polo

10

Article

Proteome-wide systems analysis of a cellulosic biofuel-producing microbe.
Andrew C Tolonen, Wilhelm Haas, Amanda C Chilaka, John Aach, Steven P Gygi & George M Church

Updated Instructions for Authors

Molecular Systems Biology has recently completed a major update of its Instructions for Authors. Of particular importance, this new document now fully incorporates information about our policies regarding transparency in scientific publishing. Molecular Systems Biology, along with the other EMBO Publications journals, has made a strong commitment to promoting transparency in the editorial process, and recently began publishing a Review Process File, containing anonymous reviewers’ reports, authors’ rebuttal letters, and the editor’s decisions, with accepted manuscripts. In addition, we have been working to promote greater availability, transparency, and re-usability for scientific data associated with published works. For more details on these efforts please see our editorial, “From bench to website.”

Data transparency

For some time now, Molecular Systems Biology has allowed authors to submit source data that directly supports a particular figure panel. Links to these data are then included in the html manuscript version, directly below the associated figures, so that readers can easily discover and reuse data that is of interest to them. This feature can be used both for numeric results (e.g. supporting a graph), or for more structured data types (e.g. SBML model files). Information regarding how source data for figures should be prepared, what types of data can be accommodated, and how to submit these files in our manuscript submission system, is now included in the Instructions for Authors.

Data deposition

Molecular Systems Biology, requires that authors submit data to public repositories according to community standards, and strongly encourages them to do so before manuscript submission. Our Instructions for Authors now provides information regarding our standards for a variety of data types, including functional genomics, proteomics, molecular interactions, and computational models.

Other improvements

These publishing policies and standards have grown out of extensive discussion with members of the scientific community, and we are eager to receive any comments or feedback you may have.