Structural determination of RNA polymerase unlocked secrets of cells.
At the age of 19 Roger Kornberg coauthored a paper with, among others, his father Arthur Kornberg and Paul Berg. This obscure paper, ‘On the heterogeneity of the deoxyribonucleic acid associated with crystalline yeast cytochrome b2’1, has the extraordinary pedigree of having three Nobel laureates among its authorship. Kornberg senior won a medical Nobel in 1959 (for discovering the mechanisms behind DNA and RNA synthesis), Berg took the chemistry prize in 1980, and now Kornberg junior, too, has snapped up a Nobel Prize in Chemistry.
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