The ENCODE (Encyclopedia of DNA Elements) project has set out to identify all the functional elements in the human genome. Detailed in a Nature web focus, a pilot project on 1% of the genome reveals new insights about how the information coded in the DNA blueprint is turned into functioning systems in the living cell. You can download a free poster at the Nature web focus, read the free-access article by the ENCODE project team (Nature 447, 799-816; 2007), and read related news stories, articles and information about the project.