Animal tests may have missed danger because monkeys ‘too clean’.

Immunologists have a new theory to explain why the devastating effects of the experimental drug TGN1412 were not spotted in animal tests. The ‘superantibody’ drug put six volunteers in intensive care in a London hospital last March.

Animals used in preclinical tests for TGN1412, researchers now say, lack a crucial set of immune cells because they are deliberately shielded from infections in the lab.

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