Reactions – Len MacGillivray

1. What made you want to be a chemist?

My undergraduate research experience. I grew up using computers, enjoyed the challenges of the sciences, and was raised in a creative (i.e., musical) environment. It all seemed to all come together when I started to perform research.

2. If you weren’t a chemist and could do any other job, what would it be – and why?

The head groundskeeper of Wrigley Field (the home and ‘shrine’ of the Chicago Cubs major league baseball team). A perfect mix of history, sports, escapism, and attention to detail.

3. How can chemists best contribute to the world at large?

Through teaching. Enthusiasm is contagious and we have an opportunity to instil an interest in such a central science for a lifetime.

4. Which historical figure would you most like to have dinner with – and why?

To be honest, each grandfather in each generation of my family. I imagine I would get quite astounding insights. From a more ‘historical’ standpoint, Winston Churchill. A strong believer and an effective leader during relatively modern and very difficult times.

5. When was the last time you did an experiment in the lab – and what was it?

I only trust my graduate and undergraduate students to find themselves around in the synthetic lab. I continue to enjoy the thrill of determining the structure of a solid for the first time.

6. If exiled on a desert island, what one book and one CD would you take with you?

Book: Shoeless Joe by W. P. Kinsella (basis for the movie ‘Field of Dreams’). Having lived in Iowa, my home is beginning to look like the house in the movie!

CD: ‘Changes in Latitudes, Changes in Attitudes’ by Jimmy Buffett (featuring ‘Margaritaville’).

Len MacGillivray is in the Department of Chemistry at the University of Iowa and works on research in the field of supramolecular chemistry, particularly as it relates to the organic solid state.

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Enzymes, macrocycles, and fluorescent dyes, oh my!

In the August issue of Nature Methods, which just came out on Monday, we have an exciting and decidedly chemistry-based paper from Werner Nau and colleagues at Jacobs University Bremen in Germany (and it even made the cover!). The authors describe a new concept for enzyme assays using a macrocycle as a receptor for a fluorescent dye and for an enzyme product. When the enzyme arrives on the scene and begins converting the substrate (which does not interact with the macrocycle) to product, the product starts displacing the fluorescent dye from the macrocycle, causing a switch-on in fluorescence. Of course, the macrocycle and dye need to be carefully chosen for each application such that the dye is out-competed by the enzyme product, but once a suitable pair is found, it provides a simple and convenient readout for enzyme activity.

Check it out!

Also of interest: a Review on caged compounds and their application in living cells and an Article describing a rapid method for detecting infectious scrapie prion protein.

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