Yes, yes, I know, it’s not quite over yet. But for us here at Nature Medicine, it already feels like the new year because we’re busy putting together our January issue.

December, and with it 2006, is history for us. But to bid the year a proper farewell, we’ve compiled the year’s best, worst and most ridiculous moments. We’ve given out awards in the style of American high school yearbooks, charted a timeline of events, highlighted the absurdity of some things in numbers and asked scientists what they thought made the biggest difference in 2006—and what they think might happen in 2007.

The fun all begins here.