One small step for women is one large step to save bones

Sclerostin is a protein that reduces bone density.

One of the biggest challenges women face after menopause due to hormonal changes is osteoporosis – a medical condition where bones become too brittle, weak and fragile. A little physical activity weekly can, however, go a long way towards protecting women’s bones at older age.

Just two hours of exercise every week for pre-menopausal women can decrease the release of sclerostin, a protein that is known to inhibit  bone formation. It also increasing levels of another protein, insulin-like growth factor 1 (IGF-1), which enhances bone formation, suggests new research from the King Abdulaziz University, Saudi Arabia. The new study is published in October’s issue of the Journal of Clinical Endocrinology and Metabolism (JCEM)

“Physical activity is good for bone health and results in lowering sclerostin, a known inhibitor of bone formation and enhancing IGF-1 levels, a positive effector on bone health” Mohammed-Salleh M. Ardawi,  a professor at the Center of Excellence for Osteoporosis Research and at KAU and lead researcher for the study, said in a press release.

The researchers randomly selected 1,235 pre-menopausal women were studied, and 58 of them were followed up over an 8 week physical activity training, to study what effect exercise will have on them. They found women who had more than two hours a week of physical activity showed a decrease in sclerostin secretion by 36.8% and an increase in IGF-1 by 107% compared to women leading a sedentary lifestyle.

Bone production is dynamic and constatly changing. Sclerostin is produced by osteocytes, the most abundant cells in bones. When osteocytes produce this glycoprotein, it migrates to the surface of the bone and inhibits the creation of cells that help bones develop. IGF-1, on the other hand, has growth-promoting effects on almost all tissues in the body, including bones.

“Physical activity training is conceptually simple, inexpensive, and can serve practical purposes including reducing the risk of low bone mass, osteoporosis, and consequently fractures,” said Ardawi. “Our study found that even minor changes in physical activity were associated with clear effects on serum levels of sclerostin, IGF-1 and bone turnover markers.”

However, research at the King Saud University, Saudi Arabia, published earlier this year in the Journal of Nutrition and Metabolism suggested that Saudi Arabian women get less physical activity compared to women elsewhere, mainly due to social restraints placed on them.

 

Sources:

Ardawi, M.S.et al. Physical Activity in Relation to Serum Sclerostin, Insulin-Like Growth Factor-1, and Bone Turnover Markers in Healthy Premenopausal Women: A Cross-Sectional and a Longitudinal Study. Journal of Clinical Endocrinology and Metabolism doi:10.1210/jc.2011-3361 (2012)

Al-Eisa, E. and Al-Sobayel, H. Physical Activity and Health Beliefs among Saudi Women. Journal of Nutrition and Metabolism doi:10.1155/2012/642187 (2012)

Pharaohs may have had a playground for pyramid building

This is a guest blogpost by Amr El Beleidy, one of Nature Middle East‘s freelancers based in Egypt.

The Bent Pyramid in the Dahshur necropolis

The Bent Pyramid in the Dahshur necropolis.{credit}Michael Hoefner/Wikipedia{/credit}

New research on the necropolis of Dahshur in Egypt has shown that the area’s landscape has been directly altered by ancient Egyptians. In a paper published in Quaternary International, researchers analyzed  fractals in the region to analyse the topography of the area to reach their conclusions.

Fractals are complex patterns repeating with magnification. Previous studies have shown that a river drainage system, such as the Nile Delta where Dahshour is located, would naturally order itself into a fractal pattern as this would minimise energy expenditure in the whole basin. The drainage channels would then imprint a fractal pattern on the topography that could be later identified.

If the human activity in the area had only altered or advanced the natural processes, fractal patterns would still emerge. However if human activity had a direct influence then there would be a low correlation between the fractal patterns of a channel network and the observed landscape.

The researchers used a digital elevation model derived from topographical maps to analyse the area. Areas around the edges of the necropolis showed a natural fractal pattern. However, the necropolis itself showed no fractals patterns which indicates direct human interaction.

While the reason for the direct alternation of landscape remains speculative, there are some clues as to why it might have been undertaken. Arne Ramisch from Freie Universitat Berlin, explains “We found a wealth of archaeological asset within the identified human influenced land forms during field trips. Examples include quarries, construction material and even an harbor occupying large areas of an potential artificial valley. Although not explicitly stated we referred to the literature and conclude: ‘Quarrying and intentional landscape architecture are major possibilities'”

The research speculate that this region could have been a training ground where ancient Egyptians practiced building pyramids. Pharaoh Sneferu may have used this area to perfect pyramid building techniques to build the nearby Bent Pyramid. This pyramid represents the transition from step pyramids to smooth-sided pyramids, the first of which was the Red Pyramid, also built by Sneferu. This might have paved the way for Sneferu’s son, Khufu, who built the Great Pyramid of Giza.

“Without further research this assumption would remain speculative,” says Ramisch . “Nevertheless, the intention of [our paper] was to establish the method rather than giving an explanation of the anthropogenic fingerprint. This remains subject for our future work.”

 

Ramisch, A. et al. Fractals in topography: Application to geoarchaeological studies in the surroundings of the necropolis of Dahshur, Egypt. Quaternary International,  doi: 10.1016/j.quaint.2012.02.045 (2012)

Muslim science heritage exhibitions comes to Doha

Museum of Islamic Arts

The Museum of Islamic Art, Doha{credit}Mohammed Yahia{/credit}

Starting this October and running into January 2013, Doha will host two traveling exhibitions that showcase the rich scholarly tradition of the Golden Age of the Islamic civilization.

The two exhibitions celebrate science achievements and innovatiosn between the seventh and 17th century in the Islamic civilization, which spread from Spain all the way to China. The 15-week event will offer a diverse programme of  interactive exhibitions, movies, live shows, cultural events and educational seminars.

The 1001 Inventions exhibition and the Arabick Roots exhibition premiered at the Royal Society in London in 2010 and 2011 respectively. The 1001 Inventions exhibition has since then traveled to Istanbul followed by New York, Los Angeles and Washington D.C, attracting well over a million visitors throughout. Interactive, fun and family-oriented, the exhibition won the title of  Best Touring Exhibition of the Year at the Museums and Heritage Excellence Awards in 2011.

The Arabick Roots exhibition celebrates the cross-boundary research between Muslim scientists and early fellows of the Royal Society, painstakingly curated by Rim Turkmani, a fellow of the Foundation for Science, Technology and Civilisation (FSTC). The version that will open in Qatar mid-October has been specifically curated for the small country’s audiences.

“With the renaissance sweeping Qatar at this time, it is the ideal time for us to highlight the achievements of our forefathers, and remind ourselves and the world what we are capable of,” commented Mansoor Al Khater, CEO of the Qatar Museums Authority. “These two exhibitions will encourage Qatar’s younger generation to innovate and contribute towards a better future. Qatar is perfectly placed to be a leader in modern science and technological innovations.”

The two exhibitions will run at the iconic Museum of Islamic Art Park, an impressive building by the sea which features some of the most beautiful and impressive cultural and scientific pieces collected from across the Islamic civilization and spanning three continents over the past thousand years. The 1001 Inventions exhibition will start 16th October and run till 12th November. The Arabick roots exhibition on the other hand will run from 17th October 2012 to 19th January 2013.

Remembering Al-Biruni – the first anthropologist

Everyone who heads to Google today will notice that the search giant has provided a new Google doodle, celebrating the anniversary of Abu Raihan Al-Biruni, a Muslim scholar often regarded as one of the greatest scientists of the medieval Islamic period.

Al-Biruni, a Persian scientist who spent the first part of his life in modern-day Afghanistan, is credited with bringing Indian science to the Islamic world – often given the title of “founder of Indology”. Little is known of his early life. He even claims he never knew his father nor his family origins. He was engaged in science at an early age, publishing his first book on cartography when he was 22 years old. Like most scientists of the era, he was a polymath, excelling and writing about various topics from astrology and mathematics to geology and anthropology.

Al-Biruni was born in a time of major political strife, several civil wars and ever changing princes ruling the land. He traveled around often, escaping wars and conflicts, before finally ending up in the court of Maḥmūd – a merciless warlord who finally ruled the whole region – probably unwillingly. He traveled into India with the warlord often, and that is where he became an expert on everything Indian and wrote some of his most encyclopedic works that documented the region’s lore, myths, science and culture. This culminated in a massive book, translated from Arabic into Verifying All That the Indians Recount, the Reasonable and the Unreasonable.

Approximately 65% of the 146 books that are known for Al-Biruni are about mathematics and astronomy, making them the fields he was most prolific in. He studied and tried to explain the rotation of the Earth, a question that he often debated with Ibn Sina (Avicenna) and dabbled in the heliocentric and geocentric hypotheses. He also studied the moon and it’s rotation and in the 18th century, Dunthorne used his data to determine the acceleration of the moon. The most important book he published on astronomy was Al-Qānūn al- Mas’udi (The Mas’udic Canon) in which he gathered all the astronomical knowledge from different sources, such as al-Khwarizmi and Ptolemy. The book was not just a collection, however, with accurate input from Al-Biruni where he developed many new mathematical techniques to improve on the measurements from the previous astronomers.

In his book The Determination of the Coordinates of Places for the Correction of Distances Between Cities, defends the role of mathematical sciences against the attack of religious scholars who could see no use for mathematics. He also used it to detail longitudes and latitudes on Earth and discussed the formation of mountains

Besides astronomy, Al-Biruni had many contributions to physics, where he unified statistics and dynamics in the science of mechanics. He was also an avid scholar of religions and studied several different ones objectively. He did not seem to disprove any, but to understand them all and the common themes that flow through them.

Less than one fifth of his books survived, the others lost along the years. Little is known of his personal life, but what is known is mostly found through his writings rather than stories about him. He remained an unwilling guest to Maḥmūd until he died, but his excursions into India with the warlord shaped much of the famous scholar’s thoughts about science, religion and tolerance.