Nature Methods | Methagora

Top downloads for March ’09

It’s a new month and time to see how papers published in Nature Methods have been received by our readers. I alway find it fascinating to see how the numbers of downloads compare to our opinion of each paper. I’ve listed the original research papers we published that received the most unique views (HTML) and downloads (PDF) in March in order of popularity and broken them down between papers published in the March issue and papers published in prior months.

Of course downloads for the March issue are based on nothing more than the title of the paper and maybe the editor’s extraordinarily brief summary. It isn’t until later that the number of downloads is more indicative of the quality and impact of a paper. For this reason the downloads of papers published prior to the March issue can be more interesting since they are more likely to be influenced by community discussion of which papers should be read and cited.

Top 4 research papers published in the March issue

1. High-efficiency labeling of sialylated glycoproteins on living cells

2. Quantitative interaction proteomics using mass spectrometry

3. Automated light-based mapping of motor cortex by photoactivation of channelrhodopsin-2 transgenic mice

4. Analysis of receptor oligomerization by FRAP microscopy

It is interesting to note that the two photoactivatable fluorescent protein papers from February made it into the March “Top 10” list below with the 3D STORM paper from last year. Super-resolution imaging related papers continue to be of high interest. It is clear though that next-generation sequencing papers continue to be the hottest papers in the journal and have barely budged from their standings last month.

Top 10 research papers published prior to the March issue

1. Mapping and quantifying mammalian transcriptomes by RNA-Seq

2. Photoactivatable mCherry for high-resolution two-color fluorescence microscopy

3. Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data

4. Stem cell transcriptome profiling via massive-scale mRNA sequencing

5. Stable knockdown of microRNA in vivo by lentiviral vectors

6. miRNA in situ hybridization in formaldehyde and EDC-fixed tissues

7. Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing

8. Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution

9. A bright and photostable photoconvertible fluorescent protein

10. Microfluidic control of cell pairing and fusion

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    Daniel Evanko said:

    Clinical research hasn’t died. The reason no clinical papers appear in the lists is because Nature Methods generally doesn’t publish clinically oriented methods. This is the purview of Nature Medicine.