April 2010 marks the first anniversary of the launch of Nature Chemistry. To celebrate, the editors have put together a compilation of their favourite articles from the first 12 issues. The selection, from ‘Chemistry goes global in the virtual world’ by Jeffrey S. Moore and Philip A. Janowicz last April, to ‘Single-molecule spectroscopy: Caught in a trap’, a News and Views article by Peter Dedecker and Johan Hofkens in the March 2010 issue, reflects the breadth of topics covered by Nature Chemistry. The collection is free to read online until the end of June 2010. Nature Chemistry first year highlights.