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Positive skew of clinical-trial publication

A news story in Nature Medicine (14, 1133; 2008) discusses an investigation into the publication status of the clinical-trials literature (PLoS Med., doi: 10.1371/journal.pmed.0050191; 2008), which concludes that positive results of clinical trials for drugs or devices have a higher chance of getting published than negative trials. The study further concludes that when the trial sponsors publish the results from ‘pivotal’ trials only 76% of the time. 

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