The Seven Stones

J Craig Venter’s Genome

Many others have abundantly commented on the publication of Craig Venter’s genome this week in PLOS Biology (Levy et al, 2007). The sequence of his full diploid genome (HuRef) reveals that the degree of genetic variability between maternal and paternal chromosomes is much higher (0.5%) than expected. Part of this variability is due to insertion/deletions (indels represent only 22% of variant events but amount to up to 75% of the variant nucleotides), alterations that are typically missed by SNP genotyping (SNPs represent 78% of the variants). Copy number variations (62, amounting to 10Mb) are also reported, albeit not determined by 

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