Nature Medicine | Spoonful of Medicine

Bundled RNA balls silence brain cancer gene expression

Scientists have developed a nanotechnology-based way to silence a key genetic switch involved in the formation of glioblastoma brain cancer. The technique, which delayed tumor growth in mice, consists of an injection of synthetic balls of RNA with a gold nanoparticle core. Researchers think similarly engineered RNA blobs, called spherical nucleic acids (SNAs), could eventually be used to treat Alzheimer’s disease and other neurodegenerative ailments. 

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