{"id":4638,"date":"2013-02-20T14:04:11","date_gmt":"2013-02-20T19:04:11","guid":{"rendered":"https:\/\/blogs.nature.com\/spoonful\/?p=4638"},"modified":"2013-02-20T14:04:11","modified_gmt":"2013-02-20T19:04:11","slug":"injectable-gel-repairs-damage-after-heart-attack-in-pigs","status":"publish","type":"post","link":"https:\/\/blogs.nature.com\/spoonful\/2013\/02\/injectable-gel-repairs-damage-after-heart-attack-in-pigs.html","title":{"rendered":"Injectable gel repairs damage after heart attack in pigs"},"content":{"rendered":"
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Processed hydrogel floats in a beaker{credit}UC San Diego Jacobs School of Engineering{\/credit}<\/p><\/div>\n

As you read this sentence, on average at least one person in the US will have started to clutch her chest. The blood flow to her heart will become blocked and cardiac muscle cells will start to die off and get replaced with scar tissue.\u00a0This person has just suffered a heart attack and most likely will go on to develop heart failure, a weakening of the heart\u2019s ability to pump blood and oxygen. In five years time, there\u2019s a 50\/50 chance she\u2019ll be dead.<\/p>\n

There are currently no treatments that can repair the damage associated with this so-called \u2018myocardial infarction\u2019 (MI), but a potential solution is now showing promise in a large-animal model. Reporting<\/a> today in Science Translational Medicine<\/em>, a team of bioengineers at the University of California\u2013San Diego (UCSD) has developed a protein-rich gel that appears to help repair cardiac muscle in a pig model of MI.<\/p>\n

The researchers delivered the hydrogel via a catheter directly into the damaged regions of the porcine heart, and showed that the product promoted cellular regeneration and improved cardiac function after a heart attack. Compared to placebo-treated animals, the pigs that received a hydrogel injection displayed a 30% increase in heart volume, a 20% improvement in heart wall movement and a 10% reduction in the amount of scar tissue scar three months out from their heart attacks. \u201cWe hope this will be a game-changing technology that can actually prevent heart failure after heart attack,\u201d says UCSD\u2019s Karen Christman<\/a>, who led the study.<\/p>\n

Christman and her team developed their hydrogel by stripping muscle cells from pig hearts, leaving behind a network of proteins that naturally self-assembles into a porous and fibrous scaffold upon injection into heart tissue. They previously<\/a>\u00a0tested its safety and efficacy in rats, where they found increased cardiac function and no toxicity or cross-species reactivity.<\/p>\n

Similar strategies using naturally-derived scaffolding, such as small intestinal submucosa from pigs in wound patching<\/a>, are well established<\/a>. The UCSD study now shows the clinical potential of this approach for cardiac regeneration after a heart attack in a large animal that more approximates humans. <\/strong>Christman has already formed a company<\/a> based on the technology, called Ventrix, and she hopes to move the product into human safety trials within the year.<\/p>\n

Jeffrey Karp<\/a>, a bioengineer at the Brigham and Women\u2019s Hospital in Boston who is working on a glue that can bind cardiac tissue in live rat and pig hearts (as reported<\/a> in a news feature this month in Nature Medicine<\/em>), believes this is promising technology. \u201cPromoting regeneration following myocardial infarction is one of the holy grails in medicine,\u201d he says.<\/p>\n

But, Karp warns, \u201cit will be important to validate these results in additional pre-clinical studies, and compare efficacy with other approaches prior to marching onward to the clinic.”<\/p>\n

Check out the video for the production process of the hydrogel:<\/p>\n