{"id":952,"date":"2010-08-26T13:02:04","date_gmt":"2010-08-26T13:02:04","guid":{"rendered":"https:\/\/blogs.nature.com\/spoonful\/2010\/08\/actos-vs-avandia-redux.html"},"modified":"2010-08-26T13:02:04","modified_gmt":"2010-08-26T13:02:04","slug":"actos_and_avandia","status":"publish","type":"post","link":"https:\/\/blogs.nature.com\/spoonful\/2010\/08\/actos_and_avandia.html","title":{"rendered":"Actos vs. Avandia redux"},"content":{"rendered":"<p>Contrary to previous papers that showed diabetes the drug Avandia (rosiglitazone) causing more heart problems than its chief rival Actos (pioglitazone), a <a href=\"https:\/\/circoutcomes.ahajournals.org\/cgi\/content\/abstract\/CIRCOUTCOMES.109.911461v1\">new study<\/a> found that the risk for heart attack, heart failure or death caused by taking either drug was about the same &amp;mdash around 4%.<\/p>\n<p>The study, which was conducted by a subsidiary of the insurance company Wellpoint and published in the journal <em>Circulation: Cardiovascular Quality and Outcomes<\/em>, examined the records of nearly 29,000 diabetes patients for 33 months.<\/p>\n<p>Some <a href=\"https:\/\/www.fiercepharma.com\/story\/study-actos-just-risky-avandia\/2010-08-25\">commentators<\/a> have pointed out that the average age of the patients in the Wellpoint study was 54 years old, whereas a <a href=\"https:\/\/jama.ama-assn.org\/cgi\/content\/abstract\/304\/4\/411\">study<\/a> appearing this year in the <em>Journal of the American Medical Association<\/em> sounding the alarm on Avandia examined patients who averaged about 74 years old.<\/p>\n<p>A <a href=\"https:\/\/www.nature.com\/nm\/journal\/v16\/n8\/full\/nm0810-831.html\">sharply divided<\/a> <span class=\"caps\">FDA<\/span> panel <a href=\"https:\/\/blogs.nature.com\/spoonful\/2010\/07\/after_avandia_some_seek_split.html\">voted last month<\/a> to keep Avandia on the market, but to append additional warnings to its prescription information.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Contrary to previous papers that showed diabetes the drug Avandia (rosiglitazone) causing more heart problems than its chief rival Actos (pioglitazone), a new study found that the risk for heart attack, heart failure or death caused by taking either drug was about the same &#038;mdash around 4%.&nbsp; <a href=\"https:\/\/blogs.nature.com\/spoonful\/2010\/08\/actos_and_avandia.html#wpn-more-952\" class=\"more-link\">Read more<\/a> <a href=\"https:\/\/blogs.nature.com\/spoonful\/2010\/08\/actos_and_avandia.html\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":167,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-952","post","type-post","status-publish","format-standard","hentry","category-drugs-drugs-and-more-drugs"],"_links":{"self":[{"href":"https:\/\/blogs.nature.com\/spoonful\/wp-json\/wp\/v2\/posts\/952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nature.com\/spoonful\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nature.com\/spoonful\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nature.com\/spoonful\/wp-json\/wp\/v2\/users\/167"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nature.com\/spoonful\/wp-json\/wp\/v2\/comments?post=952"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nature.com\/spoonful\/wp-json\/wp\/v2\/posts\/952\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nature.com\/spoonful\/wp-json\/wp\/v2\/media?parent=952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nature.com\/spoonful\/wp-json\/wp\/v2\/categories?post=952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nature.com\/spoonful\/wp-json\/wp\/v2\/tags?post=952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}