The Niche

Old stem cells made young; more maps of pluripotency

Once again, there are more great papers out there than I can write about. Below are two that will show up on the site in a few days. (Nature Reports web production schedule requires a week). Also check out Tom Zwaka’s paper that finds another, powerful control over Nanog; Sheng Ding shows that small molecules can substitute for two of the four Yamanaka factors, inching closer to reprogramming without viruses; in a high-throughput screen, Lorenz Studer shows us how known drugs affect human embryonic stem cells, a technique that might reveal unwanted side effects. (Those are all in the most recent Cell Stem Cell; see our Q&A with Sheng Ding on the potential of small molecules.) 


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