The Niche

Reprogramming with all but Oct4

There’s a paper just out in Cell today moving researchers closer to reprogramming without adding oncogenes. Sure, it starts with a cell type that’s not readily accessed in humans, but it does indicate that the cell type could matter. Also of interest should be a paper that was published in Cell last week, which compared where the four Yamanaka factors are binding in fully reprogrammed cells, partially reprogrammed cells, and fibroblasts. (See how the four factors reprogram) 

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