A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans

Worms can be ‘taught’ to prefer different temperatures. Here the authors report that worms lacking the kinase DGK-3 are very slow temperature learners. As DGK-3 is a crucial enzyme in the degradation of the signaling mediator DAG, authors hypothesize that DAG levels in thermosensory neurons determine worms’ temperature preferences, and confirm this idea experimentally.