Storing data forever

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From Nature Geoscience 3, 219 (May 2010)

Unlike accountants, scientists need to store their data forever. This expanding task requires dedication, expertise and substantial funds.

Data are at the heart of scientific research. Therefore, all data and metadata should be stored — forever, and accessibly. But it would be naïve to think that such a ‘gold standard’ of preservation could be achieved. In one spectacular example of the failure of science to save its treasures, some of NASA’s early satellite data were erased from the high-resolution master tapes in the 1980s. The lost data could now help extend truly global climate observations back to the 1960s — had they not been taped over. At the time, the storage capacity of the tapes seemed more valuable than the data they contained.

Until the introduction of full-scale supplementary information, ensuring that accessible records were kept was down to the authors. Of course, the loss of important information is unacceptable from a scientific point of view. But it is hardly surprising and probably widespread: scientists are not well-placed to guarantee continuity of data storage, especially while they are still in their vagabond years of PhD and post-doc work.

Nature Geoscience, in common with all the Nature journals, requires that authors make their data available on publication. The easiest way of ensuring that all the relevant information is accessible, and will remain so in the long term, is to use professionally run databases, which are now available for all sorts of Earth science data.

The creative push in science will always be for the production of better-resolved, more complicated data sets. Ingenious ways of storing and releasing these data are invariably developed with considerable lag. But this is not an excuse to neglect the issue. The preservation of valuable data sets and their distribution on demand is of utmost importance for the progress of science. The continuous attention of dedicated professionals — and substantial funds — is needed for database development to keep up with the science.

Howy Jacobs receives a letter

From EMBO reports 11, 325 (2010).

Dear [Dr/Prof] [Last name]

Your letter of [date] addressed to the Rector has been passed to me. The Rector thanks you for your comments and apologizes for his inability to respond personally to the many individual letters of this kind that he receives, begging your understanding in the matter.

First, please accept my sincere congratulations on your recent retirement. The University has a strong desire to remain in contact with former staff members and to ensure that their contributions over many years continue to be appropriately recognized.

On the subject of your pension, I do appreciate the difficulties resulting from your unusual career path. However, under its standard terms and conditions of service, the University is not responsible for the superannuation arrangements of its staff prior to their most recent appointment. The University’s pension scheme shows no contributions from you during the [number] years during which you were a PhD student on a tax-free scholarship, or the [number] years when you worked abroad as a postdoctoral scientist and junior faculty member. Unfortunately, where no bilateral arrangements exist between the governments concerned, pension contributions in one country cannot be counted towards those in another, nor is the pension transferable. I suggest that you take up the matter with the ministry responsible for handling social insurance matters in [name of country/countries]. The University pension scheme is also unable to credit you for the years during your career when you were on sabbatical abroad. This would have been strictly your personal responsibility or that of any sponsoring organization that supported you while you were in [name of exotic location]. I am also obliged to remind you that payment of your pension in future years is conditional on your continued residence in this country. I fully understand, as you write, that science is an ‘inherently international business’. However, this is a matter of choice and thus is not the responsibility of the employer or taxpayer.

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Dimensions of scientific diplomacy

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As scientists working in a range of disciplines come under fire in some sections of the media, Nature Physics in its February Editorial (6, 75; 2010) explains why science diplomacy matters.

The Inter-Academy Panel (IAP) counts 103 of the world’s scientific academies as members, most recently the Academies of Science of Afghanistan, Mozambique and Nicaragua, and assembles once every three or four years to discuss issues, like climate change, biodiversity or nuclear proliferation, of global significance that hinge crucially on scientific knowledge, and the gaps in that scientific knowledge.

The Nature Physics editorial continues: “The IAP initiative is typical of the approach espoused in a newly published report, ”https://royalsociety.org/New-frontiers-in-science-diplomacy">New Frontiers in Science Diplomacy: Navigating the Changing Balance of Power, which summarizes a two-day meeting organized last year by the Royal Society and the American Association for the Advancement of Science. The report stresses the vital role of science diplomacy in the modern world in three ‘dimensions’: science in diplomacy, diplomacy for science, and science for diplomacy. The first of these relates to the obvious need for scientific advice and evidence to underpin international negotiations or developments, a prominent example being the work of the existing Intergovernmental Panel on Climate Change. Diplomacy for science recognizes that “science can be a bridge to communities where political ties are weaker, but to develop relationships in these areas, scientists may require diplomatic assistance, whether in contract negotiations, intellectual property agreements or dealing with visa regulations.”

Finally, science for diplomacy acknowledges the ‘soft power’ of science, as a national asset and a universal good — and exemplified by the founding of CERN in post-war, divided Europe. Following the CERN model is the current project to build the synchrotron SESAME in Jordan, as a partnership between several Middle Eastern countries including Israel, Iran and the Palestinian Authority. Indeed the further development of scientific partnerships with the Middle East and the wider Islamic world is identified in the report as a priority for science diplomacy."

Nature Physics journal website.

Mentoring matters, says Nature Cell Biology

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Sound mentorship can contribute significantly to the intellectual and professional development of mentees, but mentors also stand to gain strong leadership skills in this process, and the ability to draw the best from a team can only aid in the overall success of one’s research agenda, according to February’s Editorial in Nature Cell Biology (12, 101; 2010). While picking the appropriate problem and the right approaches is fundamental to a running a successful research programme, capable mentoring of laboratory members and new faculty members is also crucial.

What are some of the objectives of good mentoring? The goal is to be able to recognize the individual potential of mentees and to encourage them in research projects that match their interests, skills and personalities. Successful mentors foster creativity and independence and ensure that trainees have opportunities to develop essential skills beyond bench work for their future success in research, for example, in critical analysis and communication. Instilling high ethical standards is also important. A mentor who can provide an experienced perspective on the challenges of balancing work and family is invaluable.

New PIs face multiple challenges — setting up a laboratory from scratch, recruiting and managing a team, completing administrative tasks, managing a budget, setting research priorities, writing and reviewing grants and papers, and designing and teaching classes — and often these responsibilities have to be juggled with family commitments. Time management is therefore an essential skill for the new PI. Experienced faculty members can help guide new colleagues through this thicket, as well as advise on developing a viable research agenda, navigating an increasingly competitive funding environment, negotiating with administrators and managing people.

Although a strong track record in mentorship is unlikely to be a decisive factor in tenure or funding decisions unless bolstered by a strong publication record, its importance in research is becoming better appreciated by awards and recognition by scientific societies, journals, and other organizations.

Alas, researchers with enviable publication records are not always committed to good mentoring. Graduate students and postdoctoral trainees would be well advised to consider the importance of thoughtful mentoring when choosing an advisor. Mentees exposed to good mentoring are better positioned to absorb these attributes and become successful mentors themselves. Universities, research organizations and funding bodies must promote a culture of mentorship through all levels of academia, as a supportive training environment will define and develop the next generation of scientists.

This is a shortened version of the Editorial at Nature Cell Biology (12, 101; 2010).

Nature Cell Biology journal homepage.

Nature awards for mentoring in science.

British scientists need to adopt a positive tone

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This is a shortened version of an Editorial in Nature ( 463, 402; 28 January 2010), which is free to access online.

On 11 January, a coalition of 20 leading British research universities published an editorial in The Guardian newspaper warning of impending calamity. If the spending cuts being proposed by the government are implemented, the authors asserted, the nation’s entire higher-education system, eight centuries in the making, could be undone in just six months.

Such alarmist statements have worked before. In an ordinary budget year, cries of falling skies and loss of leadership can pressure politicians to shift resources towards research. But the coming budget for Britain looks anything but ordinary. Politicians may wish to support science, but asking them to put research ahead of front-line government services such as policing and public health is not just unrealistic, it risks making scientists look petulant.

Rather than trying to convince politicians that the problem is pressing, researchers should prove to them that science can be a solution to the recession, by providing world-class education for its citizens and innovations that will set Britain apart from its competitors. They should also move the debate beyond the budget cuts, and into a broad consideration of how best to spend the limited funding that will be available.

This pro-science message will be effective only if politicians hear it again and again from all corners of the scientific establishment. At the moment, however, that seems far from happening. Most groups now mobilizing in support of science are fighting for their particular corner of the research enterprise. Fortunately, the tools for a more coherent effort are already in place. The Campaign for Science & Engineering in the UK (CaSE) is a broad coalition of charities, universities and industry that promotes science. In the run-up to the UK election, CaSE is preparing a series of letters encouraging politicians to form a positive science agenda along the lines described above. Individual researchers should add their voices to the chorus by inviting local politicians to their campuses, and by signing on to CaSE’s agenda.

The positive tone will not be enough to shield British science entirely from the cuts that lie ahead: research is only one national need among many, and cannot claim a special entitlement. But done right, it can help to ameliorate the losses and ensure that science grows quickly whenever the nation begins its recovery.

Access to biological databases must be guaranteed

The Arabidopsis Information Resource (TAIR) contains the most reliable and up-to-date genomic information available on the most widely used model organism in the plant kingdom. But TAIR now faces collapse: the US National Science Foundation (NSF) is phasing out funding after 10 years as the data resource’s sole supporter.

According to an Editorial in Nature this week (462, 252; 2009), “TAIR’s plight is emblematic of a broader crisis facing many of the world’s biological databases and repositories. Research funding agencies recognize that such infrastructures are crucial to the ongoing conduct of science, yet few are willing to finance them indefinitely. Such agencies tend to support these resources during the development phase, but then expect them to find sustainable funding elsewhere. Unfortunately, that is not easy.” Other funding agencies and private firms are not likely to step in to provide long-term support, even for relatively modest repositories and databases.

It is time for a whole new approach, argues the Editorial. “Front-line biology cannot function without these resources, so solutions must be found at both national and international levels.

Governments must ensure that at least one of their national funding agencies has money specifically set aside for the long-term support of bioresource infrastructures. A good model to emulate would be the United Kingdom’s Biotechnology and Biological Sciences Research Council, which allows databases and other such resources to apply for ring-fenced funding, saving them from having to compete with hypothesis-driven grants, which are the agencies’ mainstay.

But action is also needed on the international front. The sharing of bioresources does not and should not stop at national borders. For example, only about a quarter of TAIR users are based in the United States. China is the second biggest user at around 12%, followed by Japan at around 10%. This is not atypical. Yet it is difficult for a single national agency to justify maintaining a resource for the rest of the world. What is required is an international cost-sharing organization that could fund competitively selected infrastructures, large and small.

An international solution may be a long time coming. In the meantime, bioresource infrastructures might be wise to invest some time in public relations, giving paymasters a greater understanding of the consequences of their decisions.”

See also a related News story in the same issue of Nature (462, 258-259; 2009): Japanese science faces deep cuts.

Nature Neuroscience speaks up for young researchers

The Editorial in the November issue of Nature Neuroscience (12, 1351; 2009) emphasizes the importance of the US National Institutes of Health (NIH) policy of funding an increasing number of grants to young investigators with merit scores below the ‘payline’. Early-stage investigators are “especially vulnerable to funding crisis and are often at a disproportionate disadvantage when competing with more established laboratories for R01 grants. Such actions that protect some of these young investigators are critical if we are to retain young scientists and encourage our future research base”, states the journal. This problem may have been exacerbated by recent efforts to streamline the grant peer-review process, which may mean that evaluators are putting even more store on previous track-record, hence putting young researchers at a greater disadvantage. The Editorial identifies other factors that could be hindering young researchers in the cold funding climate. Although affirmative actions to help younger, less established, researchers are seen by some as unfair, Nature Neuroscience concludes: “Given the dismal projections for NIH budget growth, a step of this magnitude is necessary to support young investigators and to preserve the future of the scientific community as a whole.”

Nature Neuroscience journal website.

About Nature Neuroscience.

Nature Neuroscience guide to authors.

Fundamental scientific research is a vital endeavour

Obtaining financial support for scientific research is generally more difficult for work that is fundamental in nature rather than applied. In the October issue of Nature Chemistry, Bruce C. Gibb of the University of New Orleans contemplates how topics such as complexity might get their share — and why it is vital that they do (Nat. Chem. 1, 513-514; 2009). As he puts it: “The deeper and more fundamental the work, the further the bubbles of ideas and discoveries have to rise to the surface of contemporary life, and the more things become unpredictable. For example, was the Swedish physiologist Ulf Svante von Euler-Chelpin thinking about the mechanism of action of Aspirin when he was isolating compounds (prostaglandins) from sheep sperm? I think it’s safe to say that he wasn’t. Indeed, most scientists would probably agree that it doesn’t necessarily take very long for life to throw up a completely unexpected use for the knowledge created by a fundamental discovery.”

The “ideal” relationship between fundamental and applied research is explored in the article – but however one may look at it, the balance of funding is skewed in favour of applied work. Complexity is one example of fundamental chemical research, and there are welcome signs that funding agencies are beginning to recognize the importance of this discipline. Fundamental research may be harder to justify in a 30-second soundbite, but it is the “feeder system” for eventual economic benefits and societal advances.

Nature Medicine on the translation from bench to clinic

Translating a basic finding into a new therapy requires us to speak many languages—scientific, clinical, legal and financial. Yet most of us are hopelessly ‘monolingual’, a limitation that substantially slows translational research. Steps have been taken to address this problem, but a lot remains to be done, as described in September’s Editorial in Nature Medicine ‘In the land of the monolingual’ (15, 975; 2009). The Editorial begins optimistically:

“Congratulations! You’ve just published a paper in Nature Medicine identifying a new target to treat your favorite disease and are eager to take this finding to the clinic. Excellent, but where do you start? Are you familiar with all the steps you need to take from your discovery to a clinical trial?” It contiunes with much valuable advice and references for those wishing to navigate the translational pathway from bench to clinic, focusing on new initiatives in the main areas of resources and training. Even though there are some positive approaches, the Editorial concludes that “the best ways to facilitate translational research have yet to be discovered. However, their sheer existence offers hope that translational research will become smoother, speeding up the rate at which drugs and medical devices make it to the clinic. At the same time, it is clear that we need to do a lot more on a global scale to empower scientists with the education necessary to make a real translational impact. If each of us tries to become at least ‘bilingual’, we might feel a little less overwhelmed by the Tower of Babel that translational research has become.”

Related article in the same issue of Nature Medicine (15, 1006-1009; 2009):

The advancement of translational medicine—from regional challenges to global solutions

Salvatore Albani & Berent Prakken

The Arizona Arthritis Center, University of Arizona, and the Center for Molecular and Cellular Intervention, University Medical Center Utrecht. Both authors are at Eureka Institute for Translational Medicine, Siracusa, Italy.

No time to waste in assisting minorities, says Nature Immunology

The research community needs to increase the number of minority students who choose scientific research careers, according to the September Editorial in Nature Immunology (10, 927; 2009). Black and Hispanic Americans compose roughly one third of the US population, yet the percentage of graduate degrees earned by members of these minorities is much less than 30%. Only 168 people of a minority background were listed as faculty members in biological science departments of the top 50 research institutions in the United States as of 2007. How can the research community encourage more minority students to pursue a research career?

The Editorial describes varous programmes and initiatives, for example the NIH National Institute of General Medical Sciences (NIGMS) is increasing student diversity in its Maximizing Student Development initiative; the American Association of Immunologists has established a Minority Affairs Committee; the AAAS and other organizations are sponsoring the Annual Biomedical Research Conference for Minority Students, to be held this year in Phoenix, Arizona (4–7 November); and the Keystone symposia have initiated a Diversity in Life Science programme. The Editorial notes that such ‘critical mass’ networking interactions help to inspire confidence and can continue long after the attendees have returned home.

The Editorial concludes: “As the US population becomes less ‘white dominated’, more minority workers will enter the workforce. This scenario is no less true for scientific research, especially as a substantial number of white male faculty members prepare to retire in the next decade. Thus, the training of tomorrow’s scientists and faculty must begin today. To achieve this, faculty chairs and administrators must identify those hurdles that might now preclude the career development of under-represented minorities on their campuses and take steps to ensure their education programs are sufficiently rigorous to train competitive minority scientists. There is no time to waste.”