The editorial in the April issue of Nature Methods explores the role of methodological developments in the evolution of the scientific method. Some have argued that the ability to collect massive amounts of data and combine this with powerful correlative analyses will make hypothesis-driven research in biology obsolete. Others say that such ‘investigation’ is no longer science.

We suggest that some middle-ground will probably win out and both forms of inquiry will prove useful in answering important biological questions. What is your opinion?