A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

Variants in the NRG1 gene may confer an elevated risk for schizophrenia. The authors here have followed for up to 10 years a group of young people from families affected by schizophrenia. They found that one particular SNP in the NRG1 gene promotor region, substituting a T for a C nucleotide, correlates with low IQ and high risk for the disease.