Amyloid-β and tau in Alzheimer’s disease, by Frank M. LaFerla, May 2008.

Poster from Nature Reviews Neuroscience, available free online (PDF).

Alzheimer’s disease is a devastating neurodegenerative disorder with a relentless progression. Its pathogenesis is believed to be triggered by the accumulation of the amyloid-β peptide, due to overproduction and/or the failure of clearance mechanisms. This peptide, together with the microtubule-associated protein tau and their associated signalling pathways, represent important therapeutic targets for Alzheimer’s disease. The pathogenic mechanisms are described in more detail here, and are shown graphically in the Nature Reviews Neuroscience high-resolution poster.